Immunohistochemical evidence that gonads and gonad‐associated tissues are sites for enrichment with immunoglobulin‐containing cells in adult chickens

Zettergren, Leslie D.

doi:10.1002/jez.1402710108

Cited by 2 publications

(3 citation statements)

References 22 publications

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“…1998a,b), MHC class II + APC (Barua & Yoshimura 1999a; Barua et al . 2001), T cell subsets (Barua & Yoshimura 1999b) and Ig‐containing B cells (plasma cells) (Zettergren 1995; Barua et al . 1998c) have been detected in the ovarian stroma and follicular tissues of hens.…”

Section: Effects Of Age Gonadal Steroids and Molting On The Immune mentioning

confidence: 99%

Significance of local immunity in hen reproductive organs

Yoshimura

2004

Animal Science Journal

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The current paper describes aspects of local immunity in the ovary and oviduct, and the significance of immunity to reproductive functions in hens. The immunocompetent cell populations in the ovary and oviduct change with a positive correlation to sexual activity, and gonadal steroid is one of the key factors in the increase. Local immune responses mediated by major histocompatibility complex class II and T cell subsets occur in response to infection by Salmonella enteritidis , which may contaminate eggs. In the ovary, immunocompetent cells are also suggested to play roles in the regulation of ovarian functions. Macrophages and T cells are likely to enhance the regression of atretic follicles to maintain the ovarian tissue microenvironment. Autoantibodies to ovarian tissues appeared in the hens with low egg laying frequency, suggesting that the auto-antibodies may be one of the factors in the decline of egg production. In the oviduct, local immunity possibly has a role in the selection of sperm, though the immunoreactions may also affect sperm survival leading to the decline in fertility. The concentration of yolk IgY, which plays a role in maternal immunity transmission, significantly decreases with the aging of birds, whereas it is significantly increased by estrogen. Therefore, the immune system plays significant roles not only in defense against infection, but also in the functions of reproductive organs. Investigations on the local immune system in the reproductive organs and factors affecting it are of importance for the production of sterile eggs and improvement of reproductive functions.

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Section: Effects Of Age Gonadal Steroids and Molting On The Immune mentioning

confidence: 99%

Significance of local immunity in hen reproductive organs

Yoshimura

2004

Animal Science Journal

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“…1987, 1988), leading to enhanced immunoglobulin production by B cells and macrophage activity (Arstila 1994). We have localized CD4 T cells, which increase in number with sexual maturation and stimulation by estrogen, in the follicular tissues (Barua & Yoshimura 1999a), and macrophages and immunoglobulin‐containing cells in hen ovarian follicles and stroma have also been reported (Zettergren 1995; Withange et al. 1997; Barua et al.…”

Section: Discussionmentioning

confidence: 92%

“…2001) and oviduct (Zheng et al. 2001), and other immunocompetent cells, including macrophages, T cell subsets and B cells, have been found in these organs (Zettergren 1995; Barua et al. 1998a,b,c; Zheng et al.…”

Section: Introductionmentioning

confidence: 99%

Effects of intravenous injection of Salmonella antigen on the distribution of major histocompatibility complex class II positive cells in the ovarian follicles of hens

Yoshimura

Takata

2002

Animal Science Journal

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The goal of this study was to determine whether the distribution of major histocompatibility complex class II positive (MHC class II+) cells was affected by foreign agents in the blood circulation. White Leghorn layers were injected intravenously with or without formalin fixed Salmonella paratyphi, and the area of MHC class II+ cells in the ovarian follicles, which included the largest (F1) and third largest follicles (F3), white follicles (WF) and cortical follicles, was examined by immunocytochemistry. The immunoreaction products for MHC class II were observed in cells of the thecal layer of all follicles in both treated and control birds. Salmonella paratyphi antigen caused a significant increase in the area of MHC class II+ cells in the theca of the F1, F3 and WF, but not in the cortical follicles. The results suggest that the MHC class II+ cells in the theca increase in response to circulating foreign agents, and play a significant role in ovarian local immunity.

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Immunohistochemical evidence that gonads and gonad‐associated tissues are sites for enrichment with immunoglobulin‐containing cells in adult chickens

Cited by 2 publications

References 22 publications

Significance of local immunity in hen reproductive organs

Significance of local immunity in hen reproductive organs

Effects of intravenous injection of Salmonella antigen on the distribution of major histocompatibility complex class II positive cells in the ovarian follicles of hens

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