Immunohistochemical Evaluation of Angiogenesis in Warts

Bossart, Simon; Hartmeier, Lisa; Jafari, S. Morteza Seyed; Beltraminelli, Helmut; Hunger, Robert E.

doi:10.15761/crt.1000322

Cited by 1 publication

(2 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CD105 is important for assessing neoangiogenesis and is highly expressed in activated endothelial cells. It has been shown that CD105-positive vessels are newly formed and fragile; hence, they can easily rupture or bleed [ 29 ].…”

Section: Literature Search Strategy and Yielded Resultsmentioning

confidence: 99%

See 1 more Smart Citation

The Immunohistochemical Assessment of Neoangiogenesis Factors in Squamous Cell Carcinomas and Their Precursors in the Skin

Daneluzzi

Jafari

Hunger

et al. 2022

JCM

Self Cite

View full text Add to dashboard Cite

Cutaneous squamous cell carcinoma (cSCC) is a common skin cancer. Well-limited forms can be easily treated with excision, but locally advanced cancers can, unfortunately, progress to metastasis. However, it is difficult to establish the prognosis for cutaneous squamous cell carcinoma and its potential to metastasize. Therefore, this study aimed to evaluate neoangiogenesis in cSCC, as it plays a major role in the dissemination of neoplasia. A literature review was performed on selected neoangiogenic factors (VEGF, ANG1/2, Notch1, CD31/34/105, EGF, etc.). Most of them, including VEGF, EGFR, and CD105, had more elevated levels in the advanced stages of the lesion. The same is true for Notch1, p53, and TGFβ, which are the most frequently mutated tumor suppressors in this type of skin cancer. In addition, the inhibition of some of these markers, using Ang1 analogs, inhibitors of EGFR, TRAF6, or combined inhibitors of EGFR and IGF-IR, may lead to a decrease in tumor size. In conclusion, this literature review identified diagnostic and prognostic markers, as well as possible factors that can be used for the targeted therapy of spinaliomas.

show abstract

Section: Literature Search Strategy and Yielded Resultsmentioning

confidence: 99%

“…Furthermore, CD105 has an affinity for active cells in the vascular endothelium. Therefore, it has been described as a suitable neoangiogenic marker [ 28 , 29 ].…”

Section: Discussionmentioning

confidence: 99%