Immunohistochemical detection of Tyrosine Kinase receptor (TrK) in follicular and plexiform ameloblastoma – A novel study

Jisha, G; Ilayaraja, Vadivel; Yoithapprabhunath, Thuckanickenpalayam Ragunathan; Ganapathy, N.; Dineshshankar, Janardhanam; Nirmal, R Madhavan

doi:10.4103/jomfp.jomfp_220_19

Cited by 3 publications

(1 citation statement)

References 26 publications

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“…This revealed a significant difference in the expression of anti-TrK A + B + C between follicular ameloblastoma and plexiform ameloblastoma. [ 33 ] The immunoexpression of NGF was studied between follicular and plexiform ameloblastomas. All the samples showed immunopositivity, but the intensity was strong in plexiform variant compared to follicular variant.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical analysis of Nuclear Factor-kappa B (NF-κ B) between follicular and plexiform ameloblastomas: A pilot study

Sivakumar

Yoithapprabhunath

Nirmal

et al. 2020

J Oral Maxillofac Pathol

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Section: Discussionmentioning

confidence: 99%

Immunohistochemical analysis of Nuclear Factor-kappa B (NF-κ B) between follicular and plexiform ameloblastomas: A pilot study

Sivakumar

Yoithapprabhunath

Nirmal

et al. 2020

J Oral Maxillofac Pathol

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An in silico study of protein-protein interactions and design of novel peptides for TrkA in ameloblastoma

Mallick,

Yoithap Prabhunath,

Kumari

et al. 2023

Journal of Biomolecular Structure and Dynamics

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Immunohistochemical detection of nerve growth factor (NGF) in follicular and plexiform ameloblastoma – A novel study

et al. 2020

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A BSTRACT Background: Ameloblastoma is the second most common odontogenic tumor that holds a unique position among benign tumors due to its locally destructive and invasive nature. The differed tumor biology behind follicular and plexiform ameloblastoma is always an enigma. Nerve growth factor (NGF), a neurotrophin that plays a major role during odontogenesis, could also possibly play a role in the pathogenesis of odontogenic tumors such as ameloblastoma. With this background, the study was aimed to investigate the expression of NGF in follicular and plexiform ameloblastoma. Objectives: The objectives of this study were to analyze the immunohistochemical expression pattern of NGF in ameloblastoma and to compare the immunohistochemical expression pattern of NGF among the follicular and plexiform histological types of ameloblastoma. Materials and Methods: Forty histological sections of ameloblastomas (20 follicular and 20 plexiform) were stained immunohistochemically with anti-human NGF mouse IgG monoclonal antibody and the staining was analyzed statistically. Results: Almost all the 40 ameloblastoma samples (20 follicular and 20 plexiform) showed positive immunoreactivity to NGF. Both peripheral pre-ameloblast-like tall columnar cells and central stellate-reticulum-like cells showed positive reactivity. The pattern of staining was membranous in the immunoreactive cells. The χ 2 value for the immunoexpression between follicular and plexiform ameloblastoma was statistically significant with a P value <0.002. A possible mechanism has been proposed after studying the results with the downstream pathways obtained from literature. Conclusion: The pattern of expression of NGF is seen in both follicular and plexiform ameloblastoma. But the intensity is more in plexiform than that of follicular ameloblastoma.

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Immunohistochemical detection of Tyrosine Kinase receptor (TrK) in follicular and plexiform ameloblastoma – A novel study

Cited by 3 publications

References 26 publications

Immunohistochemical analysis of Nuclear Factor-kappa B (NF-κ B) between follicular and plexiform ameloblastomas: A pilot study

Immunohistochemical analysis of Nuclear Factor-kappa B (NF-κ B) between follicular and plexiform ameloblastomas: A pilot study

An in silico study of protein-protein interactions and design of novel peptides for TrkA in ameloblastoma

Immunohistochemical detection of nerve growth factor (NGF) in follicular and plexiform ameloblastoma – A novel study

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