2016
DOI: 10.6061/clinics/2016(11)04
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Abstract: OBJECTIVE:To investigate immunohistochemical markers of angiogenesis and their association with pathological prognostic features in hepatocellular carcinoma and cirrhotic liver.METHODS:Vascular endothelial growth factor, CD105, and cyclooxygenase-2 were immunohistochemically detected in 52 hepatocellular carcinoma tissue samples and 48 cirrhotic liver tissue samples. Semiquantitative measurements of vascular endothelial growth factor and cyclooxygenase-2 were evaluated considering the degree and intensity of i… Show more

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Cited by 6 publications
(13 citation statements)
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“…The studies investigating the role of endoglin in carcinogenesis of tumours (including HCC) can be divided into two groups: (1) those focused on roles of endoglin as a marker of angiogenesis and its role in diagnosis/prognostics [16,40,100], and (2) those researching pro- and anti-angiogenic mechanisms of endoglin action, based on in vitro and animal models [16,105]. The works of the former group also evaluate the effectiveness of endoglin as a marker of intratumoral MVD (IMVD), based on the results of the endoglin expression in activated ECs, i.e., the main location of this glycoprotein’s synthesis during the course of tumour angiogenesis [12,14,15,20,21,22,100].…”
Section: Endoglin In the Pathogenesis Of Hcc—experimental And Clinmentioning
confidence: 99%
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“…The studies investigating the role of endoglin in carcinogenesis of tumours (including HCC) can be divided into two groups: (1) those focused on roles of endoglin as a marker of angiogenesis and its role in diagnosis/prognostics [16,40,100], and (2) those researching pro- and anti-angiogenic mechanisms of endoglin action, based on in vitro and animal models [16,105]. The works of the former group also evaluate the effectiveness of endoglin as a marker of intratumoral MVD (IMVD), based on the results of the endoglin expression in activated ECs, i.e., the main location of this glycoprotein’s synthesis during the course of tumour angiogenesis [12,14,15,20,21,22,100].…”
Section: Endoglin In the Pathogenesis Of Hcc—experimental And Clinmentioning
confidence: 99%
“…Tissue expression of CD105 in vascular ECs (both in sinusoidal ECs in the region of the tumour and blood vessels in the portal areas of non-cancerous liver tissue) was detected by most of the authors [12,14,15,20,21,22]. The results of these studies differ, however, considering the following aspects: (1) detectability (frequency of occurrence) of CD105 immunostaining (positive, negative) in HCC and control liver; (2) location-dependent intensity of CD105 expression (tumour, adjacent non-tumorous tissue, normal liver); (3) type of statistically significant correlations (positive, negative) with clinical advancement of the tumour (TNM staging), prognosis (patient survival time), and other clinical data (e.g.…”
Section: Endoglin In the Pathogenesis Of Hcc—experimental And Clinmentioning
confidence: 99%
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