Immunohistochemical Analysis of PCNA, Ki67 and p53 in Nasal Polyposis and Sinonasal Inverted Papillomas

Mumbuç, Semih; Karakök, Metin; Bağlam, Tekin; Karataş, Erkan; Durucu, Cengiz; Kibar, Yasemin

doi:10.1177/147323000703500208

Cited by 30 publications

(22 citation statements)

References 10 publications

(11 reference statements)

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“…This parameter was also significantly higher in sinonasal IP group in comparison with controls. Similarly to our study, other authors also demonstrated higher immunoexpression of Ki67 in squamous cell carcinoma and nasal IPs with dysplasia, suggesting that a high proliferative rate is a characteristic of IP-associated malignant diseases [43][44][45][46][47]. Kawasaki et al [47] postulated survivin as the strongest apoptosis inhibitory factor, involved in the regulation of cellular proliferation in colon cancer.…”

Section: Discussionsupporting

confidence: 64%

Immunohistochemical study on survivin in sinonasal tumors and its relationship with the immunoexpression of Ki67 and Bcl-2

Stasikowska-Kanicka

Wągrowska-Danilewicz

Danilewicz

2013

Folia Histochem Cytobiol.

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Abstract:The immunoexpression of the inhibitor of apoptosis protein survivin has been shown to be a significant prognostic factor in various human cancers. Immunohistochemical method was used to examine the expression of survivin, Ki67 and Bcl-2 in 20 cases of sinonasal inverted papillomas (IPs), 12 cases of sinonasal squamous cell carcinoma (SNCs) and 19 cases of nasal chronic sinusitis as a control. Nuclear immunostaining for survivin was observed in 14 of 20 (70%) cases of sinonasal IPs and 10 of 12 (83.4%) cases of SNCs. Apart from nuclear, also weak cytoplasmic immunoexpression of survivin was detected in 2 of 20 cases (10%) of sinonasal IP and moderate intense staining in 9 of 12 cases (75%) of SNC. There was no immunostaining for survivin in 19 control cases. The immunoexpression of survivin, Ki67 and Bcl-2 was significantly higher in SNCs than in sinonasal IPs and control group. Moreover, nuclear survivin and Ki67 antigen immunoexpression were significantly higher in sinonasal IPs group as compared to control group. There were statistically significant positive correlations between nuclear (but not cytoplasmic) immunoexpression of survivin and Ki67 antigen, as well as Bcl-2 oncoprotein in both tested tumors. In conclusion, our findings suggest that survivin, Ki67 and Bcl-2 may be involved in sinonasal tumorigenesis.

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Section: Discussionsupporting

confidence: 64%

Immunohistochemical study on survivin in sinonasal tumors and its relationship with the immunoexpression of Ki67 and Bcl-2

Stasikowska-Kanicka

Wągrowska-Danilewicz

Danilewicz

2013

Folia Histochem Cytobiol.

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“…Recently, it is also found the elevated PCNA in IP compared to the sinonasal polyps by Mumbuc et al [3]. The PCNA could interact with CDK1 and promote the cell entry to the cell cycle to the consequent proliferation and cancerization.…”

Section: Discussionmentioning

confidence: 90%

“…Epistaxis and nasal obstruction with facial pain or headache attacked when the nose or sinuses mucosa bear the IP [2]. Although the IP originating from the outlining respiratory membrane belongs to a benign epithelial neoplasm, the local invasiveness, higher recurrence rate, and malignant transformation make it difficult to treat [3]. The malignant transformation rate is 5–10% and many of them are synchronous presenting with squamous cell carcinoma [4].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Correlation of Cell Cycle Proteins and Ki-67 Interaction in Paranasal Sinus Inverted Papilloma Prognosis and Squamous Cell Carcinoma Transformation

Tsou

Huang

Wang

et al. 2014

BioMed Research International

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The recurrent sinonasal inverted papilloma (IP) could be transformed to sinonasal squamous cell carcinoma. We use protein expression patterns by immunohistochemical method to see whether the expression of p53, p16, p21, and p27 belongs to cell-cycle-regulators and PCNA (proliferating cell nuclear antigen) and Ki-67 the proliferation markers in sixty patients with sinonasal inverted papilloma, and 10 of them with squamous cell carcinoma transformation. Significantly elevated levels of Ki-67, p27, and PCNA in IP with squamous cell carcinoma transformation of sinonasal tract compared with inverted papilloma were revealed. No variation of p16, p21, PLUNC (palate, lung, and nasal epithelium clone protein) and p53 expression was correlated to sinonasal IP malignant transformation by multivariate survey. However, we found elevated PLUNC expression in IPs with multiple recurrences. Finally, we found that PCNA, p27 may interact with CDK1 which promote IP cell proliferation and correlate to sinonasal squamous cell carcinoma. Ki-67 could work throughout the cell cycles to cause malignant transformation. In conclusion, this is a first study showing the correlation of Ki-67, PCNA interacted with CDK1 might lead to malignant transformation. Elevated PLUNC expression in the sinonasal IPs was related to multiple recurrences in human.

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“…Serum SCC antigen may be a useful biologic marker in patients with sinonasal IP [205–207]. Proliferating cell nuclear antigen labeling index (PCNA-LI) can be used as a strong independent indicator to judge tumor aggressive behavior, proliferative activity, development of local or regional metastases, and prognosis in nasal inverted papilloma [208, 209]. …”

Section: Etiology and Pathogenesismentioning

confidence: 99%

Skull Base Inverted Papilloma: A Comprehensive Review

2012

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Skull base inverted papilloma (IP) is an unusual entity for many neurosurgeons. IP is renowned for its high rate of recurrence, its ability to cause local destruction, and its association with malignancy. This paper is a comprehensive review of the reports, studies, and reviews published in the current biomedical literature from 1947 to September 2010 and synthesize this information to focus on its potential invasion to the base of the skull and possible intradural extension. The objective is to familiarize the clinician with the different aspects of this unusual disease. The role of modern diagnostic tools in medical imaging in order to assess clearly the limits of the tumors and to enhance the efficiency and the safety in the choice of a surgical approach is pointed out. The treatment guidelines for IP have undergone a complex evolution that continues today. Radical excision of the tumour is technically difficult and often incomplete. Successful management of IP requires resection of the affected mucosa which could be achieved with open surgery, endoscopic, or combined approach. Radio and chemotherapy were used for certain indications. More optimally research would be a multicenter randomized trials with large size cohorts.

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Immunohistochemical Analysis of PCNA, Ki67 and p53 in Nasal Polyposis and Sinonasal Inverted Papillomas

Cited by 30 publications

References 10 publications

Immunohistochemical study on survivin in sinonasal tumors and its relationship with the immunoexpression of Ki67 and Bcl-2

Immunohistochemical study on survivin in sinonasal tumors and its relationship with the immunoexpression of Ki67 and Bcl-2

Evaluation of Correlation of Cell Cycle Proteins and Ki-67 Interaction in Paranasal Sinus Inverted Papilloma Prognosis and Squamous Cell Carcinoma Transformation

Skull Base Inverted Papilloma: A Comprehensive Review

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