Immunoglobulin Levels From the Newborn Period to Adulthood and in Immunoglobulin Deficiency States*

Immunoglobulin changes in disease: quantitation on the basis of heavy polypeptide chains, IgG (gammaG), IgA (gammaA), and IgM (gammaM), and of light polypeptide chains, type K (I) and type L (II).

“…Immunoelectrophoretic analyses shown in Figure 1 illustrate some of the principal changes recorded in the present paper. Since immunoelectrophoresis is a semiquantitative technic, the quantitative immunochemical methods, used in this and other studies (50)(51)(52), have provided more specific knowledge of the serum immunoglobulin changes in disease.…”

Abnormalities in the Distribution of Serum Immunoglobulin Concentrations in Juvenile Rheumatoid Arthritis

“…The significance of the occurrence in JRA of a group with selective IgA (34). IgA deficiency has been reported in children with ataxia telangiectasia (35), in families of patients with hypogammaglobulinemia (36), in systemic lupus erythematosus (37), in steatorrhea (38), and in individuals with recurrent sinopulmonary infections (39,40). IgA deficiency has also been reported in "normal" adult males (41).…”

The Four Most Common Pediatric Immunodeficiencies

“…IgAD was first described in ataxia-telangiectasia (Thieffrey et al, 1961) and then in patients with frequent infections (West et al, 1962) and in normal subjects (Rockey et al, 1964). Low or absent IgA is a variable component of many other primary immunodeficiencies, notably all forms of agammaglobulinemia , ataxia-telangiectasia, mucocutaneous candidiasis (Kalfa et al, 2003) and IgG 2 subclass deficiency (Oxelius et al, 1981).…”