Immunoglobulin deposits in lepromatous leprosy skin. Presence of deposits in apparently uninvolved skin and occurrence of serum antiepithelial antibodies

Quismorio, Francisco P.

doi:10.1001/archderm.111.3.331

Cited by 15 publications

(8 citation statements)

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“…Linear immune deposits, predominantly of IgM, were seen at the dermoepidermal junction in 1 patient with LR and in 1 with out LR. Similar findings had been reported previously [5,29]; it had been suggested that these immune deposits may be caused by autoantibodies to the skin basement membrane. In the patient with LR, serum indeed gave a weak staining reaction in in direct immunofluorescence tests on normal human skin.…”

Section: Discussionsupporting

confidence: 90%

Serological and Immunohistological Studies on Lepromatous Leprosy

Kano¹,

Aranzazu²,

Nishimaki³

et al. 1981

Int Arch Allergy Immunol

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Sera of patients with lepromatous leprosy were studied for the presence of a variety of antibodies and immune complexes (IC). The frequencies of heterophile, Hanganutziu-Deicher and Forssman antibodies were 61 and 43%, respectively, which were significantly higher than those in other diseases. The frequency of antibodies to cardiolipin was 89% and the frequency of rheumatoid factor was 34%. Circulating IC were demonstrated in 54% of the patients’ sera by Raji-cell test and in 43% by anti-antibody inhibition test. Analyses of immunoglobulin classes of IC revealed that IgG was predominant in IC of patients with lepra reaction (LR) and IgM in patients without LR. Immune deposits were found in and between cells of dermis in skin biopsy specimens of patients with LR.

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Section: Discussionsupporting

confidence: 90%

Serological and Immunohistological Studies on Lepromatous Leprosy

Kano¹,

Aranzazu²,

Nishimaki³

et al. 1981

Int Arch Allergy Immunol

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“…Granular IgM deposition at the DEJ has been reported in allopurinol hypersensitivity, 8 granuloma faciale, 9 inflammatory macular atrophy, 10 primary biliary cirrhosis, 11 urticarial vasculitis, 12 reticulate erythematous mucinosis syndrome, 13 Jessner's lymphocytic infiltration of the skin, 14 actinic prurigo, 15 lepromatous leprosy, 16 scabies, 17 rheumatoid arthritis, 18 systemic sclerosis, 19 cyclosporine therapy, 20 and alopecia areata. 21 In our study, granular IgM deposition at the DEJ in the non-lupus group was found in patients diagnosed as having vasculitides, porphyria cutanea tarda, mixed connective tissue disease, dermatomyositis, morphea, scleroderma, erythema multiforme, eczema, erythema nodosum, photoallergic contact dermatitis, Jessner's lymphocytic infiltration, Sweet's syndrome, mycosis fungoides, trichotillomania, Well's syndrome, and granuloma faciale.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of IgM deposition at the dermo–epidermal junction

1998

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“…Different patterns of IgM staining have been described in the medical literature: linear, granular, linear granular, diffuse linear and band‐like granular. The granular pattern is found more frequently in lupus erythematosus but is also encountered in other conditions (Table ).…”

Section: Discussionmentioning

confidence: 96%

Diffuse cutaneous bullous mastocytosis with IgM deposits at dermo–epidermal junction

et al. 2015

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Cutaneous mastocytosis is a disease characterized by the infiltration and proliferation of mast cells in the skin. In children, the most common form of presentation is urticaria pigmentosa, while the diffuse cutaneous bullous mastocytosis is one of the rarest subtypes seen. The aim of this paper is to present a case of diffuse bullous mastocytosis with detection of IgM deposits at dermo-epidermal junction using direct immunofluorescence (DIF) microscopy. The diagnosis of diffuse bullous mastocytosis is a challenge, and DIF microscopy is necessary in order to exclude an autoimmune bullous disorder. However, IgM deposits at dermo-epidermal junction can be nonspecific, being found in a variety of skin disorders. A 6-month-old girl presented with bullous lesions and erosions on the scalp and the trunk. During hospitalization, further bullous lesions appeared, along with generalized erythrodermia. Skin biopsy revealed aspects of urticaria pigmentosa. Taking into account the clinical findings, the case was enclosed as bullous mastocytosis. Treatment included the avoidance of trigger factors, and administration of antihistamines along with a short-term course of systemic steroids. The evolution was favorable, with remission of the existing lesions and without occurrence of new ones.

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Immunoglobulin deposits in lepromatous leprosy skin. Presence of deposits in apparently uninvolved skin and occurrence of serum antiepithelial antibodies

Cited by 15 publications

References 0 publications

Serological and Immunohistological Studies on Lepromatous Leprosy

Serological and Immunohistological Studies on Lepromatous Leprosy

Diagnostic value of IgM deposition at the dermo–epidermal junction

Diffuse cutaneous bullous mastocytosis with IgM deposits at dermo–epidermal junction

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