Immunogenicity of Tetravalent Rhesus Rotavirus Vaccine Administered With Buffer and Oral Polio Vaccine

Overview of the Development, Impacts, and Challenges of Live-Attenuated Oral Rotavirus Vaccines

“…The IgA seroconversion rate for infants receiving the small-volume buffer with RRV-TV + OPV was comparable to infants receiving the large-volume buffer (45% and 49%, respectively). These seroconversion rates were significantly higher than those for infants that received RRV-TV with no buffer (23%) or OPV alone (13%) [298]. This means that the buffer system plays some significant roles with regards to vaccine efficacy.…”

“…The efficacy of RotaShield ® had been examined with different buffer systems-small and large buffer systems. The small buffer system contained 64 mg of sodium bicarbonate plus 24 mg sodium citrate in 2.5 mL of water, while the large buffer system contained 400 mg of sodium bicarbonate in 25 mL of soybean formula [298]. The IgA seroconversion rate for infants receiving the small-volume buffer with RRV-TV + OPV was comparable to infants receiving the large-volume buffer (45% and 49%, respectively).…”

Non-interference of Bovine-Human reassortant pentavalent rotavirus vaccine ROTASIIL® with the immunogenicity of infant vaccines in comparison with a licensed rotavirus vaccine

“…No interference by parenteral vaccines like DTP, HepB and Hib has been observed in several trials of Rotarix [9] , [10] , [11] , RotaTeq [12] , [13] and Rotashield, [14] . Further, co-administration of Rotarix with conjugate pneumococcal vaccine have also shown no interference [11] .…”

Oral, Inactivated, Whole Cell EnterotoxigenicEscherichia coliplus Cholera Toxin B Subunit Vaccine: Results of the Initial Evaluation in Children

“…In a recent pilot study, we found that the rate of complete ingestion of antacid per se in Egyptian children 6-18 months of age could be improved by administration of a small volume (15 mL) by oral syringe (Abu-Elyazeed R, unpublished data). Previously, a low-volume buffer was shown to be a practical, effective vehicle for administration of the attenuated tetravalent rhesus rotavirus vaccine [37].…”