Immunogenicity of Haemophilus influenzae Type b Polysaccharide—Tetanus Toxoid Conjugate Vaccine in Infants

RNA gene profile variation in peripheral blood mononuclear cells from rhesus macaques immunized with Hib conjugate vaccine, Hib capsular polysaccharide and TT carrier protein

“…1a and Additional file 1 : Figure S1). The previous serological analysis suggested that the antibody concentration of 0.15 μg/ml in immunized pediatric population was postulated as the positive conversion, and 1 μg/ml as meaning the immunity of long term [ 47 , 48 ]. The characteristic of the result observed in macaques and been distinct with that usually observed human is that the conjugate vaccine elicited antibody response after 1st immunization and maintained its increasing after 2nd and 3rd immunization [ 21 , 23 ], as while Hib polysaccharide antigen did weak work in macaques (Fig.…”

Combined effects of glycan chain length and linkage type on the immunogenicity of glycoconjugate vaccines

“…The failure of PRP-D was likely related to its weaker carrier protein DT 27 . Notably, in a study of almost 500 American children, there were no statistically significant differences in the geometric mean antibody concentration after three doses of PRP-T or HbOC, with 95 and 91% of infants producing >1.0 µg/mL of antibody 90 . In addition to antibody measurements, efficacy data, the ultimate parameter for vaccine success, had been determined for the four constructs.…”

Vaccines and immunotherapies for the prevention of infectious diseases having cutaneous manifestations

“…217 Two studies showed that PRP-T has an immunogenicity profile similar to that of HbOC vaccine in infants immunized at 2, 4, and 6 months of age. 218,219 The DTP-HbOC vaccine was also found to be safe and more immunogenic than separate vaccination with DTP and HbOC. 220,221 Before Hib conjugate vaccines became available, Hib was the principal cause of bacterial meningitis and a major cause of other serious invasive diseases among children aged Ͻ5 years in the United States.…”