2020
DOI: 10.5772/intechopen.90637
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Mourad Aribi

Abstract: The generation of antigen receptor diversity, and thus of the B-cell repertoire, is the result of very complex immunogenetic mechanisms. So, this chapter gives a brief overview on immunoglobulin (IG) gene organization and gene rearrangements, as well as the main mechanisms of immunoglobulin repertoire development.