Immunofluorescent "band" test for lupus erythematosus. II. Employing skin lesions

Burnham, Thomas K.

doi:10.1001/archderm.102.1.42

Cited by 22 publications

(19 citation statements)

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“…Patients with DLE who underwent long-term (1 year) chloroquine therapy responded in the same way [ 14]. Our data indicate that the clearing of immune reactants from DEJ in patients with LDLE and GDLE may occur even earlier during the treatment with HC.…”

Section: Discussionsupporting

confidence: 64%

Effects of Hydroxychloroquine on ‘Band Test’ in Discoid Lupus erythematosus

Chieregato

Peroni²,

Castellani³

et al. 1990

Dermatology

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Ten cases of localized and generalized discoid lupus erythematosus are reported in which previously untreated patients were given hydroxychloroquine sulphate 600 mg daily for 10 days followed by 400 mg for 20 days. The purpose of the study was to evaluate the effect of this drug on the ‘lupus band’ before and after treatment, in diseased, unaffected sun-exposed, and unaffected non sun-exposed skin. A good response from both the clinical and immunopathologic (i.e. reduction or disappearance of the immune reactants) standpoint was evident in 6/10 patients; in another 3 patients a good clinical but not immunopathologic response was recorded, while in 1 case a clinical worsening corresponded to an immunofluorescence improvement. In 5/10 cases (4 females 1 male) one or more immunoglobulin classes which were present in the ‘lupus band’ before therapy remained at the dermoepidermal junction after treatment.

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Section: Discussionsupporting

confidence: 64%

Effects of Hydroxychloroquine on ‘Band Test’ in Discoid Lupus erythematosus

Chieregato

Peroni²,

Castellani³

et al. 1990

Dermatology

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“…DIF patterns considered typical of LE, as previously described [11,18,19,20,21,22,23,24], are granular immune deposits, principally of IgG and IgM, and C3 found along the dermoepidermal junction. Deposits of fibrinogen in the same distribution are often found as well [27, 28].…”

Section: Methodsmentioning

confidence: 71%

“…In LE, DIF studies most commonly demonstrate granular deposits of immunoglobulin (fig. 2) and C3 at the dermoepidermal junction [11,18,19,20,21,22,23,24]. In PB, DIF is negative or occasionally demonstrates IgM [8, 25].…”

Section: Introductionmentioning

confidence: 99%

Value of Direct Immunofluorescence for Differential Diagnosis of Cicatricial Alopecia

Trachsler

Trüeb²

2005

Dermatology

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Background: There are diverse causes of cicatricial alopecia characterized by lack of follicular ostia and irreversible loss of hair. While clinical differentiation between the causes may be difficult, particularly with regard to lichen planus (LP), lupus erythematosus (LE) and pseudopelade of Brocq (PB), it has been suggested that both histopathologic examination and direct immunofluorescence studies (DIF) are necessary for an accurate diagnosis. Objective: The aim of this study was to evaluate the diagnostic value of DIF studies in addition to histopathology in patients with cicatricial alopecia as a clinical feature. Methods: 136 scalp biopsy specimens received for histopathology and DIF during a 5-year period were reviewed. Results: Definitive diagnosis was achieved by careful evaluation of scalp biopsies. The most prevalent diagnoses in order of frequency were LP (26%), LE (21%) and folliculitis decalvans (20%). PB was diagnosed in 10%. In most cases, the diagnosis could be made on the basis of histopathology and independently of DIF. Characteristic DIF patterns showed high specificity, but low sensitivity for LP, and high specificity and sensitivity for LE. The DIF pattern in PB showed no difference to LP. Conclusions: Histopathology permits diagnosis in the majority of cicatricial alopecias. DIF is of value in histopathologically inconclusive cases, particularly when LE is in question.

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“…DIF is usually negative in healthy skin. 3,28,37 Fluorescent cytoid bodies (IgA and IgM) are found in the papillary dermis and represent degeneration of basal keratinocytes. They are not exclusive to LE, since they are frequently found in lichen planus (LP) and other inflammatory dermatoses.…”

Section: Chronic Cutaneous Lupus Erythematosusmentioning

confidence: 99%

“…In systemic lupus erythematosus (SLE) immunoreactant deposits (lupus band test=LBT) 37 are essential in the diagnosis and prognosis of the disease when associated with clinical findings and serologic tests. As a diagnostic test, LBT is 60 to 90% sensitive in the photoexposed normal skin of SLE patients, as compared with non-exposed areas (40- ).…”

Section: Systemic Lupus Erythematosusmentioning

confidence: 99%

Imunofluorescência direta e indireta

Aoki

Sousa

Fukumori

et al. 2010

An. Bras. Dermatol.

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Abstract:Immunofluorescence is a valuable auxiliary diagnostic tool for autoimmune bullous diseases and inflammatory disorders, since their clinical and histopathologic findings may be inconclusive. It is a feasible laboratory method that requires experienced technicians and detects in situ and circulating immune deposits that may be involved in the pathogenesis of such skin diseases. Keywords: Autoimmunity; Basement membrane; Fluorescent antibody technique; Pemphigus Resumo: A imunofluorescência é um valioso instrumento auxiliar no diagnóstico das dermatoses bolhosas autoimunes e desordens inflamatórias, uma vez que seus achados clínicos e histopatológicos podem não ser determinantes. Consiste em um método laboratorial factível, que requer profissionais técnicos experientes, e detecta imunocomplexos in situ e/ou circulantes, que podem estar envolvidos na patogênese de tais enfermidades cutâneas.

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Immunofluorescent "band" test for lupus erythematosus. II. Employing skin lesions

Cited by 22 publications

References 0 publications

Effects of Hydroxychloroquine on ‘Band Test’ in Discoid Lupus erythematosus

Effects of Hydroxychloroquine on ‘Band Test’ in Discoid Lupus erythematosus

Value of Direct Immunofluorescence for Differential Diagnosis of Cicatricial Alopecia

Imunofluorescência direta e indireta

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