Immunofluorescence of cutaneous vasculitis associated with systemic disease

Cutaneous Vasculitis: A Presenting Feature in Hodgkin's Disease

“…It has been described in association with drug hypersensitivity, infections, connective tissue disorders and malignant disease3. A study by Schroeter et al 4 found systemic disease was present in 15 out of 26 patients with cutaneous necrotizing vasculitis and this included 2 cases with malignant lymphoma. Sams et al5 reported 3 cases of necrotizing vasculitis in association with fatal lymphoproliferative disease.…”

Prognostic Factors in Leukocytoclastic Vasculitis

“…Similar positive results were reported previously. 1,7,[28][29][30] Destruction and removal of immunoglobulins deposited in the affected dermal vessels takes place in less than 48 hours, and direct immunofluorescence studies of vasculitic lesions older than 48 hours are frequently negative. 29 The positivity of the immunofluorescence test was inversely correlated with the duration of the lesion studied by biopsy (PϽ.001).…”

Leukocyte procoagulant activity: enhancement of production in vitro by IgG and antigen-antibody complexes.

“…A direct correlation has been found between plasma fibrinopeptide A concentration and disease activity in systemic lupus erythematosus (6). In connective tissue diseases, in acute spontaneous vasculitides (7,8), and in several types of immunologically-mediated nephritis (9,11), fibrin-fibrinogen related antigen has been identified at sites of tissue damage. Fibrinfibrinogen related antigen accompanies immunoglobulin and complement deposits in vascular walls and intercellular spaces.…”