Immunoexpression of hMSH2 and hMLH1 in oral squamous cell carcinoma and its relationship to histological grades of malignancy

Abstract

The findings of the present study indicate that the histological grade of malignancy interferes in hMLH1 immunoexpression. The negativity for both hMSH2 and hMLH1 proteins in some cases suggests a possible association between OSCC and hereditary non-polyposis colorectal cancer. Further investigation from future studies is needed to elucidate this supposition.

MutSα and MutLα immunoexpression analysis in diagnostic grading of oral epithelial dysplasia and squamous cell carcinoma

“…[16][17][18] Promoter methylation and subsequent loss of hMLH1 expression has previously been associated with oral carcinogenesis and tumour progression. 14,29 Positive immunoreactivity for hMLH1 has great specificity and sensitivity for microsatellite instability detection, 30 and it is possible that previously reported intra-tumour heterogeneity in microsatellite instability for OSCC 31 may correlate with similar hMLH1 heterogeneity.…”

“…[14][15][16][17][18][19][20] Allelic imbalance in hMLH1 has been suggested to be an aetiological factor in head and neck carcinogenesis 20 and promoter methylation of this gene has been shown to be an early event in oral carcinogenesis. 14 Previous studies in this area have been limited to expression of hMLH1 and hMSH2 in either OPMD or squamous cell carcinoma.…”

Link between immunoexpression of hMLH1 and hMSH2 proteins and clinical-epidemiological aspects of actinic cheilitis

“…16 Some studies have evaluated the immunoexpression of these proteins in the degrees of dysplasia that AC may present, as well as in cancer, but no study has correlated the immunoexpression of these proteins with epidemiological and clinical aspects in AC. 5,6,8,17-19 This study is the first in the literature to analyze differences in expression of hMLH1 and hMSH2 proteins, correlating it with epidemiological and clinical characteristics of AC.…”

“…In normal tissues, the immunoexpression of the hMSH2 and hMLH1 has also been studied and correlated with the MMR system's normal function. 5-8 …”

“…4,5,8 Thus, this study aimed to evaluate the immunohistochemical expression of hMLH1 and hMSH2, comparing it with clinical aspects of AC. To our knowledge, this study is the first to associate the immunoexpression of those proteins with clinical parameters, which is important to enhance understanding of these lesions' behaviour in patients with different clinical.…”