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Cited by 53 publications
(47 citation statements)
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“…In the present study, the good immunogenicity of MOMVs was demonstrated by their roles in inducing innate and adaptive immune responses. Although OMVs carry some components of virulence factors, numerous studies have shown the safety of low-dose OMVs [15,17,22], which is also con rmed in our experiments. The unique structural characteristics with nano-scale vesicles and spherical lipid bilayers endow OMVs as a biocompatible and stable vaccine carrier [37].…”
Section: Discussionsupporting
confidence: 87%
“…In the present study, the good immunogenicity of MOMVs was demonstrated by their roles in inducing innate and adaptive immune responses. Although OMVs carry some components of virulence factors, numerous studies have shown the safety of low-dose OMVs [15,17,22], which is also con rmed in our experiments. The unique structural characteristics with nano-scale vesicles and spherical lipid bilayers endow OMVs as a biocompatible and stable vaccine carrier [37].…”
Section: Discussionsupporting
confidence: 87%
“…It is not the first time for bacterial OMVs to be considered potential vaccine candidates against bacterial infection. Previous studies have shown that OMVs derived from bacteria have protective efficacy to improve the survival rate of infection models when they are immunized in advance [11,12]. In the present study, we aim to find evidences about the defensive mechanisms involved in dendritic cells, wellknown professional antigen-presenting cells (APCs), and their relationships with adaptive immune cells such as T and B cells in the model of OMV immunization.…”
Section: Discussionmentioning
confidence: 95%
“…This vaccine contains meningococcal group B OMVs and aluminum hydroxide, which acts as the adjuvant. Aside from the meningococcal vaccine, many others based on similar principles have been proposed . For example, an engineered Staphylococcus aureus strain has been used to generate nontoxic extracellular vesicles containing antigens such as magnesium transport system membrane proteins and ferrichrome‐binding periplasmic proteins .…”
Section: Biomimetic Antibacterial Nanovaccinesmentioning
confidence: 99%