Immunization of HIV-infected children with varicella vaccine

Levin, Myron J.; Gershon, Anne A.; Weinberg, Adriana; Blanchard, Suzette; Nowak, Barbara; Palumbo, Paul; Chan, Christina Y.

doi:10.1067/mpd.2001.115972

Cited by 141 publications

(80 citation statements)

References 22 publications

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“…Neither LAIV nor TIV administration significantly altered HIV RNA viral load or CD4% at 4 weeks and 28 weeks. The absence of an effect of LAIV on HIV progression confirms earlier small trials in HIV-infected children and adults (29,30), and extends to LAIV the same safety profile with respect to HIV disease progression reported after administration of other live attenuated or inactivated vaccines (35)(36)(37)(38).…”

Section: Discussionsupporting

confidence: 83%

“…Although within the immunologic Groups studied the lymphocyte phenotype and number were not associated with response to vaccination, HIV RNA plasma level was negatively correlated with serum HAI responses. An independent effect of HIV in plasma on immune response has been reported previously with both live and inactivated vaccines administered to HIV-infected children (38,39,44).…”

Section: Discussionsupporting

confidence: 57%

See 1 more Smart Citation

Shedding of live vaccine virus, comparative safety, and influenza-specific antibody responses after administration of live attenuated and inactivated trivalent influenza vaccines to HIV-infected children

Levin

Song

Fenton

et al. 2008

Vaccine

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Section: Discussionsupporting

confidence: 83%

Section: Discussionsupporting

confidence: 57%

Shedding of live vaccine virus, comparative safety, and influenza-specific antibody responses after administration of live attenuated and inactivated trivalent influenza vaccines to HIV-infected children

Levin

Song

Fenton

et al. 2008

Vaccine

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“…Three patients, in whom tetanus toxoid-specific proliferation was measured before booster vaccine, regained specific proliferation indicating an immune reconstitution through effective ART without any booster. Zaccarelli-Filho et al (38) also observed low levels of vaccine specific antibodies in HIV-infected children, whereas other authors also observed good revaccination results concerning tetanus (39), measles, mumps, and rubella (40) and other live attenuated vaccines (41)(42)(43)(44) in most children on ART.…”

Section: Discussionmentioning

confidence: 91%

Memory B Cell Function in HIV-Infected Children—Decreased Memory B Cells Despite ART

et al. 2009

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B cell dysfunction is a well-studied complication of HIV infection in adults. Data on B cell differentiation in normal and HIV-infected children are lacking. We show the distribution of B cell subsets and immunoglobulin levels in HIV-infected children compared with controls. Furthermore, we observe the long-term B cell reconstitution of vaccine-specific immunity after antiretroviral therapy (ART). Phenotype of B cells (naive, non-switched memory, switched memory) was analyzed in 48 infected children and 62 controls. In nine HIV-infected children, functional reconstitution was quantified by tetanus-specific antibodies and by performing a lymphocyte transformation test (LTT) in a longitudinal approach.

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“…The CDC recommends immunization of asymptomatic children infected with HIV, provided that their CD4 percentage is more than 25%. Two doses of vaccine are given to HIV-infected children, 3 months apart (22,93). Children undergoing renal transplantation in France have been safely immunized, with excellent protection against varicella and a decreased incidence of zoster (16)(17)(18).…”

Section: Recommended Vaccine Use In the United Statesmentioning

confidence: 99%

Preventing Varicella-Zoster Disease

2005

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Varicella-zoster virus (VZV), the cause of chickenpox and shingles, is a pathogen in retreat following the introduction of mass vaccination in the United States in 1995. The live attenuated Oka vaccine, which is safe and immunogenic, gives good protection against both varicella and zoster in the short to medium term. It has undoubtedly been highly effective to date in reducing all forms of varicella, especially severe disease. However, the huge pool of latent wild-type virus in the population represents a continuing threat. Both the biology and the epidemiology of VZV disease suggest that new vaccination strategies will be required over time

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Immunization of HIV-infected children with varicella vaccine

Cited by 141 publications

References 22 publications

Shedding of live vaccine virus, comparative safety, and influenza-specific antibody responses after administration of live attenuated and inactivated trivalent influenza vaccines to HIV-infected children

Shedding of live vaccine virus, comparative safety, and influenza-specific antibody responses after administration of live attenuated and inactivated trivalent influenza vaccines to HIV-infected children

Memory B Cell Function in HIV-Infected Children—Decreased Memory B Cells Despite ART

Preventing Varicella-Zoster Disease

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