Immunity to influenza: Impact of obesity

Rojas-Osornio, Sandra Angélica; Cruz-Hernández, Teresita Rocío; Drago-Serrano, María Elisa; Campos-Rodrı́guez, Rafael

doi:10.1016/j.orcp.2019.05.003

Cited by 41 publications

(33 citation statements)

References 79 publications

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“…A total of 14 studies [15][16][17][18][19][20][34][35][36][37][38][39][40][41][42] reported on mortality with COVID-19 in patients with and without obesity.…”

Section: Resultsmentioning

confidence: 99%

“…Obesity impairs immunity by altering the response of cytokines, resulting in a decrease in the cytotoxic cell response of immunocompetent cells which have a key anti-viral role in addition to disturb the balance of endocrine hormones, such as leptin, that affect the interplay between metabolic and immune systems [19]. Obesity also leads to the involvement of adipose tissue-specific molecules (adipokines) in the generation of an environment that is favorable for diseases with an immune cause [20].…”

Section: Discussionmentioning

confidence: 99%

“…An increasing body of data suggests that outcomes with Coronavirus Disease 2019 (COVID- 19) are worse in those suffering from obesity and that a significant proportion of those needing intensive care suffers from overweight or obesity [1].…”

Section: Introductionmentioning

confidence: 99%

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RETRACTED: Obesity and mortality of COVID-19. Meta-analysis

Hussain

Mahawar

Xia

et al. 2020

Obesity Research & Clinical Practice

366

270

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Background: Obesity is a global disease with at least 2.8 million people dying each year as a result of being overweight or obese according to the world health organization figures. This paper aims to explore the links between obesity and mortality in COVID-19. Methods: Electronic search was made for the papers studying obesity as a risk factor for mortality following COVID-19 infection. Three authors independently selected the papers and agreed for final inclusion. The outcomes were the age, gender, body mass index, severe comorbidities, respiratory support and the critical illness related mortality in COVID-19. 572 publications were identified and 42 studies were selected including one unpublished study data. Only 14 studies were selected for quantitative analysis. Results: All the primary points but the gender are significantly associated with COVID-19 mortality. The age >70, [odd ratio (OR): 0.

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“…A total of 14 studies [15][16][17][18][19][20][34][35][36][37][38][39][40][41][42] reported on mortality with COVID-19 in patients with and without obesity.…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

RETRACTED: Obesity and mortality of COVID-19. Meta-analysis

Hussain

Mahawar

Xia

et al. 2020

Obesity Research & Clinical Practice

366

270

View full text Add to dashboard Cite

show abstract

“…Additionally, obesity [5,11] has been suggested as a risk factor for COVID-19. This may be due to impaired immune function caused by changes in cytokine responses [12] and high expression of ACE2 receptors in obese individuals [13].…”

Section: Discussionmentioning

confidence: 99%

Clinical severity of COVID-19 and general characteristics of Koreans

Paik

Kwak

2020

Preprint

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This study aimed to investigate the associations between clinical severity of COVID-19 and general characteristics of the subjects using epidemiological data of 5,601 patients with confirmed COVID-19 in Korea. The subjects of this study were diagnosed with COVID-19 from January 20 to April 30, 2020. The subjects of this study acquired information on patients with confirmed COVID-19 from the Korea Disease Control & Prevention Agency, National Medical Center and the Health Information Manager in hospitals. We found that severity of COVID-19 was greater among patients aged > 60 years, with obesity, clinical symptoms, respiratory diseases, kidney disease, and other diseases (chronic liver disease, rheumatism/autoimmune disease, and dementia). Among the variables, women had reduced clinical severity of COVID-19. Therefore, people with these factors are more susceptible to COVID-19, and they require special attention.

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“…Bu durum, kronik metabolik bozuklukların oluşmasına zemin hazırlamakla birlikte konak hücrenin, enfeksiyona karşı yanıtını da azaltmaktadır. 8,9 Obezite prevalansının artmasıyla birlikte, obezitenin bulaşıcı hastalıklar üzerindeki etkisine yönelik farkındalık giderek artmaktadır. H1N1 Influenza A (2009) virüsü salgınının sonucunda, obezite ilk kez virüs ile enfekte olan bireylerde artan hastalık şiddeti ve artan mortalite için bir risk faktörü olarak tanımlanmıştır.…”

Section: Obezite Covid-19 Pandemisinde Risk Faktörü Müdür?unclassified

Is Obesity a Risk Factor in COVID-19 Pandemic?

Gülbaran¹,

Pehlivan²

2020

Turkiye Klinikleri J Health Sci

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Obezite, harcanan enerjiden daha fazlasının uzun süreli olarak vücuda alınmasından kaynaklanan ve bu enerji rezervlerinin yağ deposu olarak depolanması nedeni ile vücut ağırlığındaki aşırı artış olarak tanımlanmaktadır. 1 Genetik, hormonal, metabolik ve davranışsal bileşenleri içeren ve kronik bir hastalık olarak kabul görülen obezitenin, özellikle geliş-miş ülkelerde prevalansı giderek artmaktadır. 2,3 Dünya Sağlık Örgütü, dünya genelinde toplam 650 milyon insanın obez [beden kitle indeksi ((BKİ)>30 kg/m 2 ] ve 1,9 milyar insanın ise aşırı kilolu (BKİ>27 kg/m 2) olduğunu tahmin etmektedir. 4 Günümüzde küreselleşme, özellikle işlenmiş ve fast-food gıdaların tüketimindeki artışlar sebebiyle diyet ve yaşam

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Immunity to influenza: Impact of obesity

Cited by 41 publications

References 79 publications

RETRACTED: Obesity and mortality of COVID-19. Meta-analysis

RETRACTED: Obesity and mortality of COVID-19. Meta-analysis

Clinical severity of COVID-19 and general characteristics of Koreans

Is Obesity a Risk Factor in COVID-19 Pandemic?

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