Immunity of Certain Anatomic Regions From Lesions of Skin Leprosy

Hopkins, Robert L.

doi:10.1001/archderm.1929.01440060003001

Cited by 9 publications

(6 citation statements)

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“…Leprosy is a chronic infectious disease with varied presentations caused by Mycobacterium leprae. The fact that few anatomic regions are relatively exempt from leprosy lesions was reported by earlier workers ( 5,8 ). The term "relatively spared zones" ("immune zones") is used in a nonimmunological sense and it does not pertain to local immunity but only to relative sparing of certain anatomical sites from leprosy lesions.…”

Section: Introductionsupporting

confidence: 51%

“…The distribution of leprosy lesions, affecting predominantly the skin, nasal mu-cosa, and peripheral nerves particularly more superficial ones is the evidence for suggesting that M. leprae prefer a growth temperature of less than 37°C ( 7,15,16 ). Certain anatomical sites like scalp, groin, axillae, perineum, and a transverse strip of skin over lumbosacral region were considered relatively unsusceptible to the development of leprosy by many workers ( 6,8,11,17 ). The unsusceptibility was attributed to the relative warmth of these regions ( 2 ).…”

Section: Discussionmentioning

confidence: 99%

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“Relatively Spared Zones” in Leprosy: A Clinicopathological Study of 500 Patients

Kaur

Danturty²,

Dogra³

et al. 2003

Int J Lepr Other Mycobact Dis

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In this study, clinically all forms of lesions like macules, plaques, and nodules were found in all the "relatively spared zones," except groins. Histopathology confirmed that the disease process was established and the acid-fast bacilli were not present as a part of bacteremic settlement. Hence, it appears that practically no area on the surface of skin is immune to invasion by M. leprae. However, as the incidence of lesions and AFB in these regions is relatively less, especially over axilla and groin, these areas can be considered as relatively spared zones but not completely resistant to development of lesions of leprosy.

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Section: Introductionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 99%

“Relatively Spared Zones” in Leprosy: A Clinicopathological Study of 500 Patients

Kaur

Danturty²,

Dogra³

et al. 2003

Int J Lepr Other Mycobact Dis

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“…Lesions occurred more frequently in borderline leprosy than in lepromatous leprosy. [8] Hopkins et al [9] screened 245 patients of leprosy and found palmar involvement in 6.9% of cases and plantar involvement in 5.9% of the cases.…”

Section: Discussionmentioning

confidence: 99%

Leprosy: An unusual presentation

Arakkal

Vani

Kasetty

et al. 2015

Int J Med Public Health

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Leprosy is a chronic infectious disease caused by Mycobacterium leprae, commonly manifesting as hypopigmented anesthetic patches with thickened nerves. Primary hyperpigmentation in leprosy is a rare manifestation. Literature search showed only few case reports of Hansen's disease with single hyperpigmented patch and involvement of relatively immune zones like palms and soles. We report a case of leprosy presenting primarily as hyperpigmented patches over the trunk and extremities with involvement of palms and soles which is a rare presentation. Abstract Case ReportAccess this article online Website: www.ijmedph.org

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“…[34] Indira et al carried out a study to assess the frequency of lesions over palms and soles. Of the 280 leprosy patients screened, 28 (10%) showed lesions over the palms and/or soles, 12 (42.8%) had only palmer lesions, 6 (21.4%) had only planter lesions, and 10 (35.7%) had both palmer and planter lesions.…”

Section: Involvement Of Palms and Solesmentioning

confidence: 99%

Immune zones in leprosy

2009

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Leprosy affects mainly those areas of skin which have a relatively lower temperature and are more exposed to trauma. Certain zones like scalp, palms and soles, genitalia, groins, axillae, eyelids, transverse band of skin over lumboscaral area, midline of back and perineum have been described to be immune to the development of lesions in leprosy. But clinical, histological and bacteriological evidence of involvement of these so called immune zones though infrequent have been documented. Hence, these immune zones should be termed as relatively immune, rather than absolutely immune zones of leprosy.

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Immunity of Certain Anatomic Regions From Lesions of Skin Leprosy

Cited by 9 publications

References 0 publications

“Relatively Spared Zones” in Leprosy: A Clinicopathological Study of 500 Patients

“Relatively Spared Zones” in Leprosy: A Clinicopathological Study of 500 Patients

Leprosy: An unusual presentation

Immune zones in leprosy

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