volume 191, issue 6, P3186-3191 2013
DOI: 10.4049/jimmunol.1301285
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Colleen Doyle-Cooper, Krystalyn E. Hudson, Anthony B. Cooper, Takayuki Ota, Patrick Skog, Phillip E. Dawson, Michael B. Zwick, William R. Schief, Dennis R. Burton, David Nemazee

Abstract: A major goal of HIV research is to develop vaccines reproducibly eliciting broadly neutralizing antibodies (bNAbs). This has proved to be challenging, however. One suggested explanation for this difficulty is that epitopes seen by bNAbs mimic self, leading to immune tolerance. We generated “knock-in” mice expressing bNAb 4E10, which recognizes the membrane proximal external region of gp41. Unlike b12 knock-in mice, described in the accompanying study, 4E10HL mice were found to undergo profound negative select…

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