Immune related genetic polymorphisms and schizophrenia among the Chinese

Chowdari, Kodavali V.; Zhang, Feng; Ma, Cui; Li, Ting; Xie, Biao Yong; Wood, Joel; Trucco, Massimo; Tsoi, W F; Saha, N.; Rudert, Willam A; Nimgaonkar, Vishwajit L.

doi:10.1016/s0198-8859(01)00256-7

Cited by 32 publications

(24 citation statements)

References 57 publications

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“…Indeed, a recent meta-analysis has shown a significant association of the G allele of rs16944 and the G allele carrier status of rs1143634 with a risk of schizophrenia in Caucasian, but not in Asian, populations [37]. Our samples provided sufficient power to detect relatively small relative risks, and therefore suggest that rs16944 and rs1143634 have no major effect on schizophrenia susceptibility in Asian populations, which is consistent with the previous Asian findings [21-23]. However, there was a trend of association of rs16944, in the opposite direction to that of the Caucasians, with schizophrenia susceptibility in female subjects.…”

Section: Discussionsupporting

confidence: 89%

“…However, this association was not confirmed in other studies [19,20]. Furthermore, none of the previous studies in Asian populations have obtained evidence for an association between IL-1β gene and schizophrenia [21-23]. All of the aforementioned association studies, except for that of Shirts, et al [19], examined only rs16944 and/or rs1143634.…”

Section: Introductionmentioning

confidence: 91%

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Possible association between Interleukin-1beta gene and schizophrenia in a Japanese population

Sasayama

Hori

Teraishi

et al. 2011

Behavioral and Brain Functions

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BackgroundSeveral lines of evidence have implicated the pro-inflammatory cytokine interleukin-1beta (IL-1β) in the etiology of schizophrenia. Although a number of genetic association studies have been reported, very few have systematically examined gene-wide tagging polymorphisms.MethodsA total of 533 patients with schizophrenia (302 males: mean age ± standard deviation 43.4 ± 13.0 years; 233 females; mean age 44.8 ± 15.3 years) and 1136 healthy controls (388 males: mean age 44.6 ± 17.3 years; 748 females; 46.3 ± 15.6 years) were recruited for this study. All subjects were biologically unrelated Japanese individuals. Five tagging polymorphisms of IL-1β gene (rs2853550, rs1143634, rs1143633, rs1143630, rs16944) were examined for association with schizophrenia.ResultsSignificant difference in allele distribution was found between patients with schizophrenia and controls for rs1143633 (P = 0.0089). When the analysis was performed separately in each gender, significant difference between patients and controls in allele distribution of rs1143633 was observed in females (P = 0.0073). A trend towards association was also found between rs16944 and female patients with schizophrenia (P = 0.032).ConclusionsThe present study shows the first evidence that the IL-1β gene polymorphism rs1143633 is associated with schizophrenia susceptibility in a Japanese population. The results suggest the possibility that the influence of IL-1β gene variations on susceptibility to schizophrenia may be greater in females than in males. Findings of the present study provide further support for the role of IL-1β in the etiology of schizophrenia.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 91%

Possible association between Interleukin-1beta gene and schizophrenia in a Japanese population

Sasayama

Hori

Teraishi

et al. 2011

Behavioral and Brain Functions

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“…reported that the frequency of the major C allele was significantly increased in Italian patients with schizophrenia as compared to the control subjects 33 . However, other studies, including the present study, failed to find an association 37–39,41 . The sample size of the present study (416 patients and 440 controls) is larger than that of Zanardini et al .…”

Section: Discussioncontrasting

confidence: 77%

“…32 Subsequently, studies replicating this work have provided confirmation that these polymorphisms and haplotypes consisting of these variants were associated with schizophrenia. [33][34][35] However, contradictory results have also been reported, [36][37][38][39][40][41][42] and these inconsistencies require further investigation. Therefore, the authors performed a case-control association study in Japanese subjects to assess whether the IL1 gene complex was implicated in vulnerability to schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

Lack of association between the interleukin‐1 gene complex and schizophrenia in a Japanese population

Watanabe

Nunokawa

Kaneko

et al. 2007

Psychiatry Clin Neurosci

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Interleukin-1 (IL1) is an inflammatory cytokine and exerts neurodegenerative effects in the brain. Several studies have indicated that IL1 is likely to be involved in the pathogenesis of schizophrenia. Recent genetic studies have revealed that the IL1 gene complex (IL,1 alpha, IL1, beta and IL1 receptor antagonist) was associated with schizophrenia, although contradictory findings have also been reported. To assess whether the IL1 gene complex was implicated in vulnerability to schizophrenia, the authors conducted a case-control association study (416 patients with schizophrenia and 440 control subjects) for nine polymorphisms in Japanese subjects. The authors found no association between the IL1 gene complex polymorphisms and schizophrenia using either singlemarker or haplotype analyses. The results of the present study suggest that the IL1 gene complex does not play a major role in conferring susceptibility to schizophrenia in the Japanese population.

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“…The possible association between this polymorphism and schizophrenia is still under debate. Whereas several studies have found an association between [Katila et al, 1999;Zanardini et al, 2003], other studies have found an association with allele 2 [Kim et al, 2004;Papiol et al, 2004], or no association [Chowdari et al, 2001].…”

Section: Introductionmentioning

confidence: 92%

Association between the interleukin‐1 receptor antagonist gene and negative symptom improvement during antipsychotic treatment†

Mata¹,

Crespo‐Facorro²,

Pérez-Iglesias³

et al. 2006

American J of Med Genetics Pt B

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The contribution of immune system to schizophrenia has been an important area of focus in schizophrenia research. Several genetic variants in the cytokine system have been associated with the pathogenesis of schizophrenia. The purpose of this study was to determine whether a pharmacogenetic relationship exists between a variable number of tandem repeats (VNTR) polymorphism in the interleukin-1 receptor antagonist gene (IL-1RN) and clinical improvement during antipsychotic treatment in patients with a first non-affective psychotic episode. One hundred and fifty-four subjects presenting with a first non-affective psychotic episode were randomly assigned to treatment with haloperidol, risperidone, or olanzapine and rated with the Brief Psychiatric Rating Scale (BPRS), the Scale for the Assessment of Negative Symptoms (SANS) and the Scale for the Assessment of Positive Symptoms (SAPS) both at baseline and after 6 weeks of treatment. A control sample of 336 blood bank donors was also included. No differences in genotype or allele distributions were found between patients and controls. However, after controlling for baseline SANS scores, the genotype in the VNTR polymorphism in the IL-1RN gene significantly predicted negative symptom improvement, accounting for approximately 7% of the variance (F = 5.23, df = 2, P = 0.006). The mean decrease in SANS scores was 58% for the IL-1RN* 2/2, 44% for the IL-1RN* 1/2, and 14% for the IL-1RN* 1/1 subjects, respectively. These results suggest that the VNTR polymorphism in the IL-1RN gene may be a useful predictor of negative symptom improvement in schizophrenic patients treated with antipsychotic drugs.

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Immune related genetic polymorphisms and schizophrenia among the Chinese

Cited by 32 publications

References 57 publications

Possible association between Interleukin-1beta gene and schizophrenia in a Japanese population

Possible association between Interleukin-1beta gene and schizophrenia in a Japanese population

Lack of association between the interleukin‐1 gene complex and schizophrenia in a Japanese population

Association between the interleukin‐1 receptor antagonist gene and negative symptom improvement during antipsychotic treatment†

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