Immune-mediated subepithelial blistering diseases of the mucous membranes. Improving the detection of circulating autoantibodies by the use of concentrated serum samples

Korman, N. J.

doi:10.1001/archderm.132.10.1194

Cited by 9 publications

(9 citation statements)

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“…If the serum does not contain detectable antibodies, concentrated serum should be used (Korman and Watson, 1996). If these results are negative, two other tests can be performed.…”

Section: Diagnosismentioning

confidence: 99%

Number III Mucous membrane pemphigoid

2005

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Mucous membrane pemphigoid (MMP) is a sub-epithelial vesiculobullous disorder. It is now quite evident that a number of sub-epithelial vesiculobullous disorders may produce similar clinical pictures, and also that a range of variants of MMP exist, with antibodies directed against various hemidesmosomal components or components of the epithelial basement membrane. The term immune-mediated sub-epithelial blistering diseases (IMSEBD) has therefore been used. Immunological differences may account for the significant differences in their clinical presentation and responses to therapy, but unfortunately data on this are few. The diagnosis and management of IMSEBD on clinical grounds alone is impossible and a full history, general, and oral examination, and biopsy with immunostaining are now invariably required, sometimes supplemented with other investigations. No single treatment regimen reliably controls all these disorders, and it is not known if the specific subsets of MMP will respond to different drugs. Currently, apart from improving oral hygiene, immunomodulatory-especially immunosuppressive-therapy is typically used to control oral lesions. The present paper reviews pemphigoid, describing the present understanding of this fascinating clinical phenotype, summarising the increasing number of subsets with sometimes-different natural histories and immunological features, and outlining current clinical practice.

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“…If the serum does not contain detectable antibodies, concentrated serum should be used (Korman and Watson, 1996). If these results are negative, two other tests can be performed.…”

Section: Diagnosismentioning

confidence: 99%

Number III Mucous membrane pemphigoid

2005

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“…However, there have been case studies in which the significance of the antibodies to desmoplakin or periplakin does not represent paraneoplastic pemphigus. 15,16,17 Table 1 shows a literature list of mixed BP and PV cases that do not represent PNP.…”

Section: Discussionmentioning

confidence: 99%

Combined bullous pemphigoid and pemphigus vulgaris in an 18‐year‐old female

et al. 2010

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We present a case of an 18-year-old female with clinical, histological and immunopathological features of overlapping pemphigus vulgaris and bullous pemphigoid. This case is unique both in the context of the distinctive hybrid nature of the bullous disorder and the young age of onset. An initial biopsy showed a combined pemphigus pattern histologically and a dominant pemphigoid pattern by immunofluorescence, hence posing a diagnostic conundrum. A subsequent biopsy however confirmed a combined pemphigus and pemphigoid pattern both in the context of the light microscopic findings and by immunofluorescence. The pathophysiologic basis of this distinctive hybrid dermatosis along with the other reported cases of overlapping pemphigus and pemphigoid are reviewed.

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“…These results are comparable with those of recent studies of human patients with AISBD for which indirect IF percentages of detection are reported up to100% of cases. However, such successful rates were sometimes achieved via testing of undiluted or even concentrated sera 26,27 . Also, one of these studies stressed that tests were more rewarding when carried out on sera collected on untreated patients presented during an active episode of the disease 26 .…”

Section: Discussionmentioning

confidence: 99%

Isotype determination of circulating autoantibodies in canine autoimmune subepidermal blistering dermatoses

Favrot

Dunston

Paradis

et al. 2003

Veterinary Dermatology

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The three most common canine autoimmune blistering skin diseases (AISBD), bullous pemphigoid (BP), mucous membrane pemphigoid (MMP) and epidermolysis bullosa acquisita (EBA) have recently been separated based on clinical, histological and immunological grounds. The objectives of this study were to determine the isotype profiles of circulating autoantibodies in these dermatoses. Serum was collected from 5 dogs with BP, 15 with MMP and 11 with EBA. All sera were tested using an indirect immunofluorescence method using salt-split canine gingiva as substrate. Anti-basement membrane IgG autoantibodies were detected in all patients. Among the IgG autoantibodies, IgG1 and IgG4 were encountered most frequently, while IgG2 and IgG3 were uncovered in some dogs. IgE autoantibodies were detected more often than IgA or IgM autoantibodies in any of the three entities. The predominance of IgG1, IgG4 and IgE autoantibody isotypes in dogs with AISBD is very similar to the situation found in humans with the homologous diseases.

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Immune-mediated subepithelial blistering diseases of the mucous membranes. Improving the detection of circulating autoantibodies by the use of concentrated serum samples

Cited by 9 publications

References 0 publications

Number III Mucous membrane pemphigoid

Number III Mucous membrane pemphigoid

Combined bullous pemphigoid and pemphigus vulgaris in an 18‐year‐old female

Isotype determination of circulating autoantibodies in canine autoimmune subepidermal blistering dermatoses

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