2016
DOI: 10.18632/aging.101116 View full text |Buy / Rent full text
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Abstract: Chronological age is not a good indicator of how each individual ages and thus how to maintain good health. Due to the long lifespan in humans and the consequent difficulty of carrying out longitudinal studies, finding valid biomarkers of the biological age has been a challenge both for research and clinical studies. The aim was to identify and validate several immune cell function parameters as markers of biological age. Adult, mature, elderly and long-lived human volunteers were used. The chemotaxis, phagocy… Show more

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“…These processes can be deduced to the progressing weakness of immune response. The general immune response really decreases with aging [1], and there are some theories that point to the central role of declining immune system on the general aging as well as to the lifespan [2][3][4]. However, it is not clear that whether the deterioration of the immune system is the cause of the general senescence or it becomes senescent as a part of the general aging of the organism.…”
Section: Introductionmentioning
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rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…These processes can be deduced to the progressing weakness of immune response. The general immune response really decreases with aging [1], and there are some theories that point to the central role of declining immune system on the general aging as well as to the lifespan [2][3][4]. However, it is not clear that whether the deterioration of the immune system is the cause of the general senescence or it becomes senescent as a part of the general aging of the organism.…”
Section: Introductionmentioning
“…In the corresponding trend lines, best fit is given by exponential curves (see Table 1). Note that positive normalized age difference (BA -CA)/CA corresponds to young, negative difference to elderly participants around CA about 35 years for female and about 45 years for male participants recovered from the blood immunology and dermal and epidermis cell profile (Martínez de Toda et al 2016) are showing very good correspondence. Such difference can be attributed to the impact of the estrogens assumed suppressors of innate immunity (Csaba 2019).…”
Section: Discussionmentioning
“…Quantization of the phagocytosis of opsonized sheep erythrocytes by macrophages was done visually under optical microscope by measuring the numbers of monocytes attached to the membrane surface of opsonized sheep erythrocytes (membrane-bound monocytes) and the number of monocytes that have ingested opsonized sheep erythrocytes (monocyte-ingested erythrocytes), as a percentage of the overall monocyte numbers. Mastocyte count measurement was incorporated into the experimental procedure as their levels were shown to decrease with aging in animal experiments (Benjamin 1947;Voitenko and Tokar 1983;Hart et al 1999;Martínez de Toda et al 2016;Kang et al 2017;Csaba 2019;Fahy et al 2019).…”
Section: Assessment Of the Immune System Statementioning
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