2012
DOI: 10.1371/journal.pntd.0001717
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Abstract: Background The clinical syndrome associated with secondary syphilis (SS) reflects the propensity of Treponema pallidum ( Tp ) to escape immune recognition while simultaneously inducing inflammation. Methods To better understand the duality of immune evasion and immune recognition in human syphilis, herein we used a combination of flow cytometry, immunohistochemistry (IHC), and transcriptional profiling to study the i… Show more

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Cited by 102 publications
(113 citation statements)
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“…MT35060CI). Deidentified, banked sera from HIV-negative patients with secondary syphilis were from two distinct geographic sources: (i) Dallas, TX (approved for use by the Institutional Review Board of the University of Connecticut Health Center [UCHC]), and (ii) Cali, Colombia, collected after we obtained informed consent under protocols approved by the human subject boards at the Connecticut Children's Medical Center (CCMC), UCHC, and the CIDEIM (43,44).…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…MT35060CI). Deidentified, banked sera from HIV-negative patients with secondary syphilis were from two distinct geographic sources: (i) Dallas, TX (approved for use by the Institutional Review Board of the University of Connecticut Health Center [UCHC]), and (ii) Cali, Colombia, collected after we obtained informed consent under protocols approved by the human subject boards at the Connecticut Children's Medical Center (CCMC), UCHC, and the CIDEIM (43,44).…”
Section: Methodsmentioning
confidence: 99%
“…After obtaining informed consent, we took two punch biopsy specimens from the affected skin of two different patients with untreated secondary syphilis (designated Cali-77 and Cali-84) seen at our Cali, Colombia, study site (43,44) according to protocols approved by the human subject boards at CCMC, UCHC, and CIDEIM (43,44). DNA was extracted using the QIAamp DNA minikit (Qiagen) according to procedures recommended by the manufacturer, eluted in 100 l of elution buffer at 70°C, and stored at Ϫ80°C.…”
Section: Immunofluorescence Analysis Of E Coli Cells Expressing 326mentioning
confidence: 99%
“…For example, the causal agent of syphilis, T. pallidum, enhances the concentrations of cytokines, including several interferons, and thereby evades recognition by the immune system (Cruz et al, 2012). Specific interferons are also thought to contribute to the survival of Chlamydia in human hosts (Duell et al, 2012).…”
Section: Alternative Explanations For Phenotypic Alterations In Parasmentioning
confidence: 99%
“…It typically presents as one or multiple vegetating nodules and/or plaques on the extremities of middle aged to elderly adults [10]. Necrosis, pustules, fistulae, and circulating NK-cell numbers and is associated with the emergence of an atypical circulating CD56-negative CD16-positive NK-cell population which is poorly cytolytic and has impaired capacity to produce IFN gamma and other cytokines [15]. Interestingly, these NK-cell line changes are also observed in uncontrolled HIV patients.…”
Section: Discussionmentioning
confidence: 99%
“…The mechanism for syphilis-driven immune dysregulation is not fully elucidated. The spread of syphilis into the bone marrow may alter the proper development of the myeloid and lymphoid progenitors of NKcells along with macrophages and dendritic cells [15,16].…”
Section: Discussionmentioning
confidence: 99%