Immune cytokines and regulation of body temperature, food intake and cellular immunity

Hori, Tetsuro; Nakashima, Toshihiro; Take, Sachiko; Kaizuka, Yasuo; Mori, T.; Katafuchi, Toshihiko

doi:10.1016/0361-9230(91)90117-3

Cited by 90 publications

(29 citation statements)

References 26 publications

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“…The superpotent ␣-MSH analog (Nle 4 ,DPhe 7 )-␣-MSH, was approximately 10 times more potent than ␣-MSH in reducing fever when given centrally . Fevers caused by endotoxin (Martin and Lipton, 1990;Goelst et al, 1991;Villar et al, 1991;Huang et al, 1998) and the cytokines IL-1 (Robertson et al, 1986;Daynes et al, 1987), IL-6 (Martin et al, 1991) and TNF (Martin et al, 1991), but not those caused by IFN-␣ (Hori et al, 1991) and prostaglandin E 2 (Davidson et al, 1992), were inhibited by ␣-MSH. The antipyretic message sequence of ␣-MSH (1-13) resides in the C-terminal tripeptide Lys-Pro-Val (Richards and Lipton, 1984b).…”

Section: Melanocortin Receptors and Control Of Inflammationmentioning

confidence: 99%

Targeting Melanocortin Receptors as a Novel Strategy to Control Inflammation

et al. 2004

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Section: Melanocortin Receptors and Control Of Inflammationmentioning

confidence: 99%

Targeting Melanocortin Receptors as a Novel Strategy to Control Inflammation

et al. 2004

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“…Immune cytokines, such as interleukin-l/ and interferon-a, are known to cause a wide spectrum of central responses such as fever (Dinarello et al 1984; Nakashima, Hori, Kuriyama & Matsuda, 1988), slow wave sleep (Krueger, Dinarello, Shoham, Davenne, Walter & Kubillus, 1987), anorexia (Kuriyama, Hori, Mori & Nakashima, 1990;Hori, Nakashima, Take, Kaizuka, Mori & Katafuchi, 1991 a) and a modulation of nociceptive functions (Blalock & Smith, 1981). Furthermore, it has been recently demonstrated that a central administration of interleukin-1/?…”

Section: Introductionmentioning

confidence: 99%

Roles of sympathetic nervous system in the suppression of cytotoxicity of splenic natural killer cells in the rat.

Katafuchi

Take

Hori

1993

The Journal of Physiology

101

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SUMMARY1. We previously demonstrated that a central injection of interferon-a in rats induced a suppression of cytotoxicity of splenic natural killer cells which depended upon intact splenic sympathetic innervation, suggesting the important role of the splenic nerve in immunosuppression. To further study the mechanisms of this phenomenon, we investigated: (1) the effects of a central injection of recombinant human interferon-x on the electrical activity of the splenic nerve, and (2) the responses of splenic natural killer cytotoxicity on the electrical stimulation of the splenic nerve in urethane with a-chloralose anaesthetized rats,2. An injection of recombinant human interferon-a (1'5 x 10o and 6'0 x 10t units (u) per rat) into the third cerebral ventricle produced a sustained and long lasting (at least for more than 60 min) increase in the electrical activity of splenic sympathetic nerve filaments in a dose-dependent manner. Following an intra-third-ventricular injection of recombinant human interferon-a at a dose of 6'0 x 103 u, the efferent discharges were elevated 2-6 times that of the pre-injection level with a mean onset latency of 12 min (8-16 min). No changes in the arterial blood pressure and body temperature were observed after injections of recombinant human interferon-a.3. The excitation of the nerve activity induced by intra-ventricular recombinant human interferon-a was reversibly suppressed by an intravenous injection of an oploid antagonist, naloxone (1 mg/kg in 0'1 ml saline), whereas the injection of naloxone alone did not affect either the baseline level of the nerve activity or the systemic blood pressure.4. The cytotoxicity of natural killer cells in the spleen measured by a standard chromium release assay was reduced 20 min after the laparotomy alone in anaesthetized rats. The reduced natural killer activity then recovered significantly when the splenic nerve was out immediately after the laparotomy. When the peripheral cut end of the splenic nerve was subsequently stimulated (0 5 mA, 0'5 ms, 20 Hz for 20 min), a further suppression of natural killer cytotoxicity was observed.5. The reduction of natural killer cytotoxicity produced by the stimulation of the splenic nerve was completely blocked by an intravenous injection of nadolol (a peripherally acting fi-adrenergic receptor antagonist), but not by that of prazosin (an a-antagonist).

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“…The systemic administration of LPS, a powerful activator of the innate immune system and the most commonly used experimental model for systemic infection, induces a variety of sicknessassociated responses such as anorexia, increased slow-wave sleep (Hori et al, 1991;Elmquist et al, 1997), change in nociceptive threshold, and fever (Benamar et al, 2000(Benamar et al, , 2005Abe et al, 2001). The fever due to LPS and other exogenous pyrogens is believed to be caused by the synthesis and release from monocytes and macrophages of a number of well characterized endogenous pyrogenic factors, including interleukin (IL)-1, IL-6, tumor necrosis factor (TNF)-␣, and macrophage inflammatory protein-1 (Myers et al, 1994;Blatteis, 2006).…”

mentioning

confidence: 99%

A Novel Role of Cannabinoids: Implication in the Fever Induced by Bacterial Lipopolysaccharide

Benamar

Yondorf²,

Meissler³

et al. 2006

J Pharmacol Exp Ther

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There is continuing interest in elucidating the actions of drugs of abuse on the immune system and on infection. The present study investigated the effects of the cannabinoid (CB) receptor agonist aminoalkylindole, (ϩ)-WIN 55,212-2 [(4,5-dihydro-2-methyl-4(4-morpholinylmethyl)-1-(1-naphthalenyl-carbonyl)-6H-pyrrolo[3,2,1ij]quinolin-6-one], on fever produced after injection of lipopolysaccharide (LPS), a component of the outer membrane of Gram-negative bacteria, the best known and most frequently used experimental model. Intraperitoneal injection of LPS (50 g/kg) induced a biphasic fever, with the first peak at 180 min and the second at 300 min postinjection.

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Immune cytokines and regulation of body temperature, food intake and cellular immunity

Cited by 90 publications

References 26 publications

Targeting Melanocortin Receptors as a Novel Strategy to Control Inflammation

Targeting Melanocortin Receptors as a Novel Strategy to Control Inflammation

Roles of sympathetic nervous system in the suppression of cytotoxicity of splenic natural killer cells in the rat.

A Novel Role of Cannabinoids: Implication in the Fever Induced by Bacterial Lipopolysaccharide

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