Immune cell circulating subsets are affected by gonadal function

Giglio, Tina; Imro, Maria Adele; Filaci, Gilberto; Scudeletti, Marco; Puppo, Francesco; Cecco, L. De; Indiveri, Francesco; Costantini, Sergio

doi:10.1016/0024-3205(94)00508-7

Cited by 144 publications

(100 citation statements)

References 17 publications

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“…Clinical studies have shown that patients, including pre-menopausal women, who have undergone a total abdominal hysterectomy including a bilateral oophorectomy experience a decrease in the CD4: CD8 T-cell ratio and in B cells numbers (Giglio et al 1994;Kumru et al 2004). Interestingly, these changes are reversed by hormone therapy (HT) (Giglio et al 1994;Kumru et al 2004).…”

Section: Introductionmentioning

confidence: 99%

“…Interestingly, these changes are reversed by hormone therapy (HT) (Giglio et al 1994;Kumru et al 2004). Additional studies have reported that post-menopausal women (between the age of 52 and 70) taking HT for at least 12 months prior to the study have increased numbers of B cells and better T-cell proliferative responses than post-menopausal women who are not undergoing any HT (Porter et al 2001).…”

Section: Introductionmentioning

confidence: 99%

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Accelerated immune senescence and reduced response to vaccination in ovariectomized female rhesus macaques

Engelmann

Barron

Urbanski

et al. 2010

AGE

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Aging is associated with a general dysregulation in immune function, commonly referred to as "immune senescence". Several studies have shown that female sex steroids can modulate the immune response. However, the impact of menopauseassociated loss of estrogen and progestins on immune senescence remains poorly understood. To help answer this question, we examined the effect of ovariectomy on T-cell homeostasis and function in adult and aged female rhesus macaques. Our data show that in adult female rhesus macaques, ovariectomy increased the frequency of naïve CD4 T cells. In contrast, ovariectomized (ovx) aged female rhesus macaques had increased frequency of terminally differentiated CD4 effector memory T cells and inflammatory cytokine-secreting memory T cells. Moreover, ovariectomy reduced the immune response (T-cell cytokine and IgG production) following vaccination with modified vaccinia ankara in both adult and aged female rhesus macaques compared to ovary-intact age-matched controls. Interestingly, hormone therapy (estradiol alone or in conjunction with AGE (2011) 33:275-289

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Accelerated immune senescence and reduced response to vaccination in ovariectomized female rhesus macaques

Engelmann

Barron

Urbanski

et al. 2010

AGE

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“…As fêmeas têm a função imune mais ativa, tanto do sistema imune humoral, quanto ao mediado por células, também denominado inato (BILBO & NELSON, 2001;ENGELAND et al, 2003;SCHUURS & VERHUL, 1990;ZUK & MCKEAN, 1996). Este dimorfismo sexual origina-se principalmente de ação de hormônios gonadais, tendo a testosterona efeito supressivo em ambas vertentes do sistema imune RODEN et al, 2004;VISELLI et al 1997), enquanto o estrógeno aumenta a imunidade (GIGLIO et al, 1994). Ainda as fêmeas desenvolvem tolerância ao efeito do LPS de forma mais rápida do que machos (ENGELAND et al, 2003), sendo o fenômeno dependente da fase do ciclo estral e da fase fisiológica (ENGELAND et al, 2006;NASCIMENTO et al, 2013).…”

Section: Discussionunclassified

Efeitos Da Administração Pós Natal De Lipopolissacarideo No Dimorfismo Sexual Da Prole De Ratos

Nascimento¹,

Felício²,

Rodrigues³

et al. 2015

Acta Biomed.Bras.

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RESUMOProcessos inflamatórios no período pré e pós-natal estariam envolvidos com expressões de comportamentos em animais de laboratório e, em humanos, com doenças psiquiátricas. Neste sentido, já se mostrou também que doenças psiquiátricas são dependentes do gênero. O lipopolissacarídeo (LPS) é uma endotoxina bacteriana empregada como ativador do sistema imune. A administração em período precoce da vida de ratos promove alterações quando desafiados na idade adulta com a mesma endotoxina. No sentido de investigar estas diferenças, este trabalho examinou diferenças sexuais em ratos cujo sistema imune foi ativado no quinto dia pós-natal (PND5) por LPS. Assim, ratos machos e fêmeas receberam no PND5 50 μg/kg de LPS i.p. ou o seu veículo e na idade adulta, fêmeas e machos tratados ou não pós-natalmente com LPS, receberam 100 μg/kg de LPS i.p e foram observados o peso e a atividade geral em campo aberto. Os resultados mostraram que: 1) Na infância o tratamento com LPS não modificou o peso corporal e a atividade geral dos animais; 2) Na idade adulta observou-se aumento da frequência de locomoção e levantar nas ratas tratadas pós-natalmente com LPS em relação aos animais machos do mesmo grupo. Conclui-se, portanto que fêmeas expostas pós-natalmente com LPS apresentam maior tolerância a uma segunda dose de LPS na idade adulta com relação aos animais machos que receberam o mesmo tratamento.Palavras chave: LPS, Inflamação, Comportamento, Dimorfismo sexual. ABSTRACTAs evidenced in several instances, inflammatory process within the pre-and postnatal period may cause the expression of psychiatric disease behaviour. Lipopolysaccharide (LPS) is a bacterian endotoxin, frequently used in biomedical experiments, is an activator of the immunological system. Administration of this endotoxin in an early life stage in rats can provoke alteration in the exploratory behavior when challenged with the same endotoxin later in life. The main objective of this study was to analyze sexual differences in rats, whose immune system was activated by LPS in the fifth postnatal day (PND5), and the consequences of this treatment for explorative behaviour in adulthood. To achieve these goals, male and female rats received 50µg/kg of LPS on PND5. The rats were observed until the day 21. On PND21 the general activity of treated rats was assessed and compared with the control group of animals. In adult age, a challenge dose of LPS (100µg/Kg) was administered to all groups. The behaviour was analyzed two hours post treatment in the open field. The LPS treatment on PND5 was unable to alter the body weight

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“…Postmenopausal women receiving HT exhibit decreased plasma levels of the inflammatory factors TNFα (Vural et al 2006a), IFNγ (Deguchi et al 2001), andIL-6 (De Martinis et al 2005;Saucedo et al 2002). HT increases the absolute numbers of CD4 cells, B cells, and NK cells, in addition to increasing T cell proliferative capacity (Giglio et al 1994;Kumru et al 2004;Porter et al 2001). However, given the potential complications caused by HT (increased risk of cardiovascular events and breast cancer), more studies need to be conducted to establish the optimal age of initiation, duration, dose, and type of HT.…”

Section: Hormone Replacementmentioning

confidence: 99%

Improving immunity in the elderly: current and future lessons from nonhuman primate models

Meyer

Kerns

Haberthur

et al. 2011

AGE

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The immune system must overcome daily challenges from pathogens to protect the body from infection. The success of the immune response to infection relies on the ability to sense and evaluate microbial threats and organize their elimination, while limiting damage to host tissues. This delicate balance is achieved through coordinated action of the innate and adaptive arms of the immune system. Aging results in several structural and functional changes in the immune system, often described under the umbrella term "immune senescence". Age-related changes affect both the innate and adaptive arms of the immune system and are believed to result in increased susceptibility and severity of infectious diseases, which is further exacerbated by reduced vaccine efficacy in the elderly. Therefore, multiple strategies to improve immune function in the aged are being investigated. Traditionally, studies on immune senescence are conducted using inbred specific pathogen free (SPF) rodents. This animal model has provided invaluable insight into the mechanisms of aging. However, the limited genetic heterogeneity and the SPF status of this model restrict the successful transfer of immunological discoveries between murine models and the clinical setting. More recently, nonhuman primates (NHPs) have emerged as a leading translational model to investigate immune senescence and to test interventions aimed at delaying/reversing agerelated changes in immune function. In this article, we review and summarize advances in immunorestorative approaches investigated in the NHP model system and discuss where the NHP model can support the development of novel therapeutics.

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Immune cell circulating subsets are affected by gonadal function

Cited by 144 publications

References 17 publications

Accelerated immune senescence and reduced response to vaccination in ovariectomized female rhesus macaques

Accelerated immune senescence and reduced response to vaccination in ovariectomized female rhesus macaques

Efeitos Da Administração Pós Natal De Lipopolissacarideo No Dimorfismo Sexual Da Prole De Ratos

Improving immunity in the elderly: current and future lessons from nonhuman primate models

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