2017
DOI: 10.1080/15287394.2017.1286898
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Immune biomarkers in older adults: Role of physical activity

Abstract: Aging is associated with a decline in the normal functioning of the immune system. Several studies described the relationship between immunological alterations, including immunosenescence and inflammation, and aging or age-related outcomes, such as sarcopenia, depression, and neurodegenerative disorders. Physical activity is known to improve muscle function and to exert a number of benefits on older adult health, including reduced risk for heart and metabolic system chronic diseases. However, the positive infl… Show more

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Cited by 24 publications
(17 citation statements)
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References 95 publications
(122 reference statements)
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“…Exercises are considered as crucial modulators that may regulate the immune system and prevent premature immunosenescence. Systematic activity is a safe mode of intervention in preventing chronic low-grade inflammation in older people [35]. It is still debated whether the magnitude of changes in immune cell levels is dependent on exercise intensity.…”
Section: Discussionmentioning
confidence: 99%
“…Exercises are considered as crucial modulators that may regulate the immune system and prevent premature immunosenescence. Systematic activity is a safe mode of intervention in preventing chronic low-grade inflammation in older people [35]. It is still debated whether the magnitude of changes in immune cell levels is dependent on exercise intensity.…”
Section: Discussionmentioning
confidence: 99%
“…56 There are other situations in which decreased CD4/CD8 cell ratios have been recorded; in early menopause with inadequate oestrogen levels, for example, where they can be restored with hormone replacement therapy (from 1.4% ± 0.16 to 2.4% ± 0.3%), 57 or with immune senescence resulting from ageing. 58 Viral infection, particularly cytomegalovirus infection, is also associated with a similar increase in the CD4/CD8 ratio through an expansion of CD8 cells, although these tend to be in the EM and EMRA T cell compartments rather than naïve T cells. 59 Other chronic infections, such as tuberculosis, dimorphic fungal infections, toxoplasmosis, and leishmaniasis, also lead to CD8 expansion with altered ratios.…”
Section: Discussionmentioning
confidence: 99%
“…The available scholarly literature seems to suggest that chronic exercise is a safe mode of intervention to prevent immunosenescence, chronic low-grade inflammation and improve the effectiveness of flu vaccination in elderly populations without harmful side effects ( 22 24 ).…”
Section: Physical Activity As a Tool To Counteract Immunosenescencementioning
confidence: 99%