Immobilized Glucose Oxidase on Boronic Acid-Functionalized Hierarchically Porous MOF as an Integrated Nanozyme for One-Step Glucose Detection

Zhao, Zhenghong; Huang, Yaojing; Liu, Wenren; Ye, Fanggui; Zhao, Shulin

doi:10.1021/acssuschemeng.9b07631

Cited by 100 publications

(50 citation statements)

References 32 publications

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“…Accordingly, researchers used Au NPs instead of GOD and peroxidase mimics instead of HRP to realize the quantitative detection of glucose (Fig. 3a) [39][40][41] .…”

Section: Resultsmentioning

confidence: 99%

Glucose-oxidase like catalytic mechanism of noble metal nanozymes

et al. 2021

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Au nanoparticles (NPs) have been found to be excellent glucose oxidase mimics, while the catalytic processes have rarely been studied. Here, we reveal that the process of glucose oxidation catalyzed by Au NPs is as the same as that of natural glucose oxidase, namely, a two-step reaction including the dehydrogenation of glucose and the subsequent reduction of O2 to H2O2 by two electrons. Pt, Pd, Ru, Rh, and Ir NPs can also catalyze the dehydrogenation of glucose, except that O2 is preferably reduced to H2O. By the electron transfer feature of noble metal NPs, we overcame the limitation that H2O2 must be produced in the traditional two-step glucose assay and realize the rapid colorimetric detections of glucose. Inspired by the electron transport pathway in the catalytic process of natural enzymes, noble metal NPs have also been found to mimic various enzymatic electron transfer reactions including cytochrome c, coenzymes as well as nitrobenzene reductions.

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“…Accordingly, researchers used Au NPs instead of GOD and peroxidase mimics instead of HRP to realize the quantitative detection of glucose (Fig. 3a) [39][40][41] .…”

Section: Resultsmentioning

confidence: 99%

Glucose-oxidase like catalytic mechanism of noble metal nanozymes

et al. 2021

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“…[49] Similarly, Zhao et al used the boronic acid-functionalized hierarchically porous MIL-88B (HP-MIL-88B-BA) with POD-mimicking catalytic activity as a matrix for the immobilization of GOx to prepare a biomimetic cascade catalytic nanoreactor. [27] Using a surface adsorption method, Zhong et al employed MOF-545(Fe) with POD-like activity as a support for the immobilization of enzymes to construct a multi-enzyme mimicking cascade catalytic system (Figure 1B). The cascade catalytic system based on the immobilized enzyme exhibited outstanding reusability and high stability (such as thermal stability and long-term stability).…”

Section: Biomimetic Gox-pod Cascade Catalysismentioning

confidence: 99%

“…[81] Copyright 2018, American Chemical Society. GOx-MA-Hem/Au-Ag Glucose 0.0050 × 10 −3 to 2.0 × 10 −3 m 1.8 × 10 −6 m [91] GOx@HP-MIL-88B-BA Glucose 2 × 10 −6 to 100 × 10 −6 m 0.98 × 10 −6 m [27] Fe SSN-GOx Glucose 10 × 10 −3 to 100…”

Section: Colorimetric Biosensingmentioning

confidence: 99%

Enzyme Mimics for Engineered Biomimetic Cascade Nanoreactors: Mechanism, Applications, and Prospects

Zhang

Chen

et al. 2021

Adv Funct Materials

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Multiple enzyme-driven biological catalytic cascades occur in living organisms, guiding highly efficient and selective transformations of substrates. Inspired by the merits of these biological catalytic cascade systems, enormous efforts have been devoted to developing novel cascade catalytic systems to mimic biological cascade catalytic reactions over the past few years. Nanozymes, a class of enzyme mimics, are nanomaterials with enzyme-like catalytic activity. The emergence and development of nanozymes has significantly advanced the development of biomimetic cascade nanoreactors. Currently, biomimetic cascade nanoreactors driven by advanced nanozymes have been widely used and exhibit many advantages such as superior cascade catalytic efficiency and high stability, resulting in significant advancements in biosensing and biomedical applications. The latest advances in understanding the cascade catalytic mechanism of nanozyme-engineered biomimetic cascade catalytic nanoreactors and their progressive applications for biosensing and biomedical applications are comprehensively covered here. First, nanozyme and enzyme/nanozyme-engineered biomimetic cascade catalytic nanoreactors are categorized according to their catalytic mechanism and properties. Then, the biosensing and biomedical applications, including cancer therapy, antibacterial activity, antioxidation, and hyperuricemia therapy of the cascade catalytic systems are covered. The conclusion describes the most important challenges and opportunities remaining in this exciting area of research.

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“…This BCN first catalyzes glucose to generate H 2 O 2 , and then the H 2 O 2 is further catalyzed by iron components within the MOF matrix, leading to the oxidation of POD substrate 3,3,5,5‐tetramethylbenzidine (TMB) ( Figure A). [ 72 ] It is also possible to encapsulate other natural enzymes, or even multiple enzymes, within an MOF. For example, Zhang and colleagues fabricated neutrophil‐mimetic nanocatalysts by loading GOx and chloroperoxidase in zeolitic imidazolate framework (ZIF)‐8 and then performing a surface modification process via neutrophil membrane coating (Figure 2B–E).…”

Section: Design and Fabrication Of Ros Catalytic Nanomedicines For Combating Bacteria/biofilmsmentioning

confidence: 99%

Section: Design and Fabrication Of Ros Catalytic Nanomedicines For Combating Bacteria/biofilmsmentioning

confidence: 99%

Biocatalytic Nanomaterials: A New Pathway for Bacterial Disinfection

et al. 2021

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Clinical treatment of pathogenic infection has emerged as a growing challenge in global public health. Such treatment is currently limited to antibiotics, but abuse of antibiotics have induced multidrug resistance and high fatality rates in anti‐infection therapies. Thus, it is vital to develop alternative bactericidal agents to open novel disinfection pathways. Drawing inspiration from elements of the human immune system that show great potential for controlling pathogens or regulating cell apoptosis, the design of biocatalytic nanomaterials (BCNs) have provided unrivaled opportunities for future antibacterial therapies. More significantly, BCNs exhibit various superior properties to immune cells and natural enzymes, such as higher biocatalytic performance, extraordinary stability against harsh conditions, and scalable production. In this review, the most recent efforts toward developing BCN‐based biomedical applications in combating bacterial infections are focused upon. BCNs’ antibacterial mechanisms, the classification of BCNs, antibacterial activities that can be triggered or augmented by energy conversion, and the eradication of biofilms with BCNs are systematically introduced and discussed. The current challenges and prospects of BCNs for biocatalytic disinfection are also summarized. It is anticipated this review will provide new therapeutic insights into combating bacteria and biofilms and offer significant new inspiration for designing future biocatalytic nanomaterials.

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Immobilized Glucose Oxidase on Boronic Acid-Functionalized Hierarchically Porous MOF as an Integrated Nanozyme for One-Step Glucose Detection

Cited by 100 publications

References 32 publications

Glucose-oxidase like catalytic mechanism of noble metal nanozymes

Glucose-oxidase like catalytic mechanism of noble metal nanozymes

Enzyme Mimics for Engineered Biomimetic Cascade Nanoreactors: Mechanism, Applications, and Prospects

Biocatalytic Nanomaterials: A New Pathway for Bacterial Disinfection

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