Immobilization of polyoxometalate on aminosilane-modified silicate: Synthesis, characterization and antibacterial performance

Wu, Kuo‐Hui; Chang, Yin-Chiung; Wang, Je-Chuang

doi:10.1166/mex.2019.1569

Cited by 10 publications

(3 citation statements)

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“…AgNPs are closely related to antimicrobial ability, which depends on the AgNPs content in Pc-Ormosil. Compared with the results of our previous literature [7,8,22], the AgPc-Ormosil/Ag composites exhibit better antimicrobial properties than Ormosil(NR 4 + Cl − )/Ag, Ormosil/POM, and Ormosil(NR 4 + Cl − )/POM. These results may be due to the relatively small and uniform distribution of AgNPs in the AgPc-Ormosil/Ag composites.…”

Section: Antibacterial Effectscontrasting

confidence: 56%

Synthesis, characterization and antimicrobial properties of silver phthalocyanine-silver (AgPc-Ag) supported on aminosilane-modified silicate

Wu,

Huang,

Wang

et al. 2024

Preprint

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Organic–inorganic composite antibacterial materials based on AgPc/Ag and aminosilane-modified silicate (Ormosil) were prepared by sol-gel processes and an in situ reduction method. The physical and chemical properties of AgPc, Pc-Ormosil and AgPc-Ormosil/Ag composites were analyzed by SEM, XRD, NMR and XPS spectroscopy. As a result, Ag nanoparticles were bonded and chelated in Pc-Ormosil matrix. The morphology analysis of SEM showed that the AgNPs in the Pc-Ormosil matrix were spherical and uniformly distributed, with a size of about 5–10 nm. These NMR and XPS results indicated that the AgNPs were coordinated with Pc (N–Ag–N) and chelated with Ormosil (–CH2NH…Ag and Si–OH…Ag) to form a AgPc-Ormosil/Ag composite. The antibacterial effects of AgPc-Ormosil/Ag composites on Gram-negative Pseudomonas aeruginosa and Escherichia coli, and Gram-positive Staphylococcus aureus and Bacillus subtilis were evaluated by inhibiting ring, minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and plate counting, and excellent antibacterial properties were obtained.

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Section: Antibacterial Effectscontrasting

confidence: 56%

Synthesis, characterization and antimicrobial properties of silver phthalocyanine-silver (AgPc-Ag) supported on aminosilane-modified silicate

Wu,

Huang,

Wang

et al. 2024

Preprint

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“…Recently, several antibacterial nanomaterials were reported due to their superiority of antibacterial ability with drug-resistant and drug-loading capacity with sustained release 15 - 17 . The release of antimicrobial agents such as metallic ions is a valid method 18 , 19 . Because of the multiple antibacterial mechanisms aiming at the structure and physiological processes of bacteria, the NPs based antibacterial agents exhibit sustained broad-spectrum antibacterial effects 20 .…”

Section: Introductionmentioning

confidence: 99%

Mild temperature photothermal assisted anti-bacterial and anti-inflammatory nanosystem for synergistic treatment of post-cataract surgery endophthalmitis

Yang¹,

He²,

Qiao³

et al. 2020

Theranostics

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Rationale: Endophthalmitis, which is one of the severest complications of cataract surgeries, can seriously threaten vision and even lead to irreversible blindness owing to its complicated microenvironment, including both local bacterial infection and severe inflammation. It is urgent to develop a comprehensive treatment for both anti-bacterial and anti-inflammatory effects. Methods: Herein, we developed AuAgCu 2 O-bromfenac sodium nanoparticles (AuAgCu 2 O-BS NPs), which was designed to combine anti-bacterial and anti-inflammatory effects for integrated therapy of endophthalmitis after cataract surgery. The AuAgCu 2 O-BS NPs could eradicate methicillin-resistant Staphylococcus aureus (MRSA) bacterial strain relied on their photodynamic effects and the release of metal ions (Ag + and Cu + ) by the hollow AuAgCu 2 O nanostructures mediated mild photothermal effects. The anti-inflammatory drug, bromfenac sodium, released from the nanoparticles were able to significantly reduce the local inflammation of the endophthalmitis and promote tissue rehabilitation. In vivo bacterial elimination and anti-inflammation were confirmed by a postcataract endophthalmitis rabbit model. Results: Excellent antibacterial ability of AuAgCu 2 O-BS NPs was verified both in vitro and in vivo . Ophthalmological clinical observation and pathologic histology analysis showed prominent treatment of inflammatory reaction. Importantly, the mild temperature photothermal effect not only promoted the release of metal ions and bromfenac sodium but also avoided the thermal damage of the surrounding tissues, which was more suitable for the practical application of ophthalmology due to the complex structure of the eyeball. Moreover, superior biocompatibility was approved by the preliminary toxicity investigations, including low cytotoxicity, negligible damage to major organs, and stable intraocular pressure. Conclusions: Our studies of nanosystem provide a promising synergic therapeutic strategy for postcataract endophthalmitis treatment with favorable prognosis and promise in clinical translations.

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“…In particular, the covalently modified POMs with organic pendants exhibited high stability under physiological conditions, providing an attractive strategy for improving their biological distribution [116] . Wu et al used aminosilane-modified silicates as surface modifiers and stabilizers for POMs nanoparticles, inhibiting the growth of multiple bacteria and preventing aggregation [117] . The folding of polypeptides in POM-peptide materials (POMlymers) facilitated the self-assembly of nanomaterials in a specific environment.…”

Section: Bacteriostatic Applicationmentioning

confidence: 99%

Latest progress in covalently modified polyoxometalates-based molecular assemblies and advanced materials

Zhang

Zhao

et al. 2022

Polyoxometalates

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Covalently modified polyoxometalates (POMs), which benefit from the synergistic effect between POMs and covalently grafted moieties, have received increasing attention in various fields. Recent studies on the covalently modified POMs mainly focus on the function-directed POMs assemblies. In this review, we summarized the latest progress (2017-2022) of covalently modified POMs from functional perspective, which can be classified as assembly chemistry, photochemistry, electrochemistry, homogeneous/heterogeneous catalysis and biological application.The roles of POMs and covalently grafted moieties in these hybrids, especially the rational design for the specific application were considered and emphasized.

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Immobilization of polyoxometalate on aminosilane-modified silicate: Synthesis, characterization and antibacterial performance

Cited by 10 publications

References 0 publications

Synthesis, characterization and antimicrobial properties of silver phthalocyanine-silver (AgPc-Ag) supported on aminosilane-modified silicate

Synthesis, characterization and antimicrobial properties of silver phthalocyanine-silver (AgPc-Ag) supported on aminosilane-modified silicate

Mild temperature photothermal assisted anti-bacterial and anti-inflammatory nanosystem for synergistic treatment of post-cataract surgery endophthalmitis

Latest progress in covalently modified polyoxometalates-based molecular assemblies and advanced materials

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