volume 269, issue 1, P259-265 2004
DOI: 10.1016/j.ijpharm.2003.09.023
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Abstract: Physical connection of vaccine carriers with immunostimulating cytokines may provide an interesting possibility to enhance the immune response of protective or therapeutic vaccines. As a first evaluation, various aluminium hydroxide adjuvants and poly(D,L-lactide-co-glycolide) (PLGA) microparticulates with modified positively and negatively charged surfaces were prepared to adsorb granulocyte-macrophage colony-stimulating factor (GM-CSF) under different pH conditions. Negatively charged surfaces were chosen to…

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