Immediate Release 3D-Printed Tablets Produced Via Fused Deposition Modeling of a Thermo-Sensitive Drug

Kempin, Wiebke; Domsta, Vanessa; Grathoff, Georg; Brecht, Iris; Semmling, Beatrice; Tillmann, Susan; Weitschies, Werner; Seidlitz, Anne

doi:10.1007/s11095-018-2405-6

Cited by 126 publications

(89 citation statements)

References 40 publications

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“…In this regard, three-dimensional (3D) printing may offer an elegant and practical solution to the problem. 3D printing is an additive manufacturing technique in which an object is built up in a layer-by-layer manner [10][11][12][13][14], based on a 3D model designed using computer-aided design (CAD) software [15][16][17][18][19]. At present, 3D printing is often used to produce engineering prototypes due to its fast production speed and cost-effectiveness [20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

3D Printed Tablets (Printlets) with Braille and Moon Patterns for Visually Impaired Patients

et al. 2020

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Visual impairment and blindness affects 285 million people worldwide, resulting in a high public health burden. This study reports, for the first time, the use of three-dimensional (3D) printing to create orally disintegrating printlets (ODPs) suited for patients with visual impairment. Printlets were designed with Braille and Moon patterns on their surface, enabling patients to identify medications when taken out of their original packaging. Printlets with different shapes were fabricated to offer additional information, such as the medication indication or its dosing regimen. Despite the presence of the patterns, the printlets retained their original mechanical properties and dissolution characteristics, wherein all the printlets disintegrated within ~5 s, avoiding the need for water and facilitating self-administration of medications. Moreover, the readability of the printlets was verified by a blind person. Overall, this novel and practical approach should reduce medication errors and improve medication adherence in patients with visual impairment.

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Section: Introductionmentioning

confidence: 99%

3D Printed Tablets (Printlets) with Braille and Moon Patterns for Visually Impaired Patients

et al. 2020

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“…Fused deposition modelling (FDM) 3D printing has therefore been proposed as an alternative method for 3D printing of tablets [16,17] and medical devices [18]. The method allows the fabrication of immediate [19][20][21], delayed [22,23], extended release tablets [24][25][26][27][28] as well as for dual drug delivery systems [29][30][31]. The technology offers several advantages such as the lower cost, absence of finishing step, small place requirement and obviation for material recycling [13,32].…”

Section: Introductionmentioning

confidence: 99%

‘Temporary Plasticiser’: A novel solution to fabricate 3D printed patient-centred cardiovascular ‘Polypill’ architectures

Pereira

Isreb

Forbes

et al. 2019

European Journal of Pharmaceutics and Biopharmaceutics

155

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Hypertension and dyslipidaemia are modifiable risk factors associated with cardiovascular diseases (CVDs) and often require a complex therapeutic regimen. The administration of several medicines is commonly associated with poor levels of adherence among patients, to which World Health Organisation (WHO) proposed a fixed-dose combination unit (polypill) as a strategy to improve adherence. In this work, we demonstrate the fabrication of patient-specific polypills for the treatment of CVDs by fused deposition modelling (FDM) 3D printing and introduce a novel solution to meet critical quality attributes. The construction of poly(vinyl alcohol) (PVA)-based polypills containing four model drugs (lisinopril dihydrate, indapamide, rosuvastatin calcium and amlodipine besylate) was revealed for the first time. The impact of tablet architecture was explored using multi-layered and unimatrix structures. The novel approach of using distilled water as a 'temporary co-plasticiser' is reported and was found to significantly lower the extruding (90°C) and 3D printing (150°C) temperatures from 170°C and 210°C respectively, with consequent reduction in thermal stress to the chemicals. XRD indicated that lisinopril dihydrate and amlodipine besylate maintained their crystalline form while indapamide and rosuvastatin calcium were essentially amorphous in the PVA tablets. From the multilayer polypills, the release profile of each drug was dependent on its position in the multilayer.In addition to the multilayer architecture offering a higher flexibility in dose titration and a more adaptive solution to meet the expectations of patient-centred therapy, we identify that it also allows orchestrating the release of drugs of different physicochemical characteristics. Adopting such an approach opens up a pathway towards low-cost multidrug delivery systems such as tablets, stents or implants for wider range of globally approved actives.

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“…Orodispersible, sublingual, fast-dissolving drug delivery formulations that rapidly disintegrate in the oral cavity or immediate-release tablets by 3D printing have been produced [12][13][14][15].…”

Section: Recent Accomplishments In Modified-release 3d-printed Tabletsmentioning

confidence: 99%

3D-Printed Modified-Release Tablets: A Review of the Recent Advances

Siamidi¹,

Tsintavi²,

Rekkas³

et al. 2020

Molecular Pharmacology

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The broad spectrum of applications of three-dimensional printing (3D printing, 3DP) has attracted the attention of researchers working in diverse fields. In pharmaceutics, the main idea behind 3D printing products is to design and develop delivery systems that are suited to an individual's needs. In this way, the size, appearance, shape, and rate of delivery of a wide array of medicines could be easily adjusted. The aim of this chapter is to provide a compilation of the 3D printing techniques, used for the fabrication of oral drug delivery systems, and review the relevant scientific developments in particular those with modified-release characteristics.

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Immediate Release 3D-Printed Tablets Produced Via Fused Deposition Modeling of a Thermo-Sensitive Drug

Abstract: The knowledge acquired through this work might be very beneficial for future FDM applications in the field of immediate release tablets especially with respect to thermo-sensitive drugs.

Cited by 126 publications

References 40 publications

3D Printed Tablets (Printlets) with Braille and Moon Patterns for Visually Impaired Patients

3D Printed Tablets (Printlets) with Braille and Moon Patterns for Visually Impaired Patients

‘Temporary Plasticiser’: A novel solution to fabricate 3D printed patient-centred cardiovascular ‘Polypill’ architectures

3D-Printed Modified-Release Tablets: A Review of the Recent Advances

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