Immediate Changes in Lung Compliance Following Natural Surfactant Administration in Premature Infants with Respiratory Distress Syndrome: a Controlled Trial

Animal-derived surfactants for the treatment and prevention of neonatal respiratory distress syndrome: summary of clinical trials

“…Thus, the short-term advantages of calfactant are presumably mediated, at least in part, by its higher SP-B concentration ( Table 2). [17][18][19] Beractant vs alveofact Baroutis 2003: This small (n = 80), single-center study randomized patients to receive beractant, alveofact or poractant for treatment of RDS, and included infants Ͻ32 weeks gestation whose BW was Ͻ2000 g. The study design was less rigorous, and less than 35% of participants were exposed to antenatal steroids. The beractant group received dosing via a side-port adapter at slow infusion rate, which may have affected the delivery of surfactant.…”

“…The calfactant group weaned from mechanical ventilation sooner and required fewer doses of surfactant than the beractant group, but there were no differences in study outcomes. 18 Bloom and Clark 2005: This publication reported the outcomes of two trials, conducted between 2001 and 2003, and used a rigorous study design, including 'intentionto-treat' analyses. At least 73% of participants were exposed to antenatal steroids.…”

What’s new in surfactant?

“…Infasurf was found to have a more rapid effect, without having an effect on overall incidence of bronchopulmonary dysplasia (BPD) or mortality. Subgroup analysis showed a decrease in mortality after prophylactic Survanta treatment in infants under 600 g. A more recent, smaller study reported a decrease in number of doses required with Infasurf without any differences in outcome [7].…”

“…Two studies have compared Survanta and Infasurf (calfactant) for the treatment of RDS [7,17]. The largest study compared the efficacy of the two surfactants for prophylactic administration as well as for rescue treatment [17].…”

Effects of surfactants on preterm infant lungs

“…Attar et al 18 compared the immediate changes in lung compliance following the administration of two commercially available natural surfactants. Forty preterm infants required surfactant and received either calfactant or beractant.…”