Immediate but not long-term intranasal administration of insulin raises blood pressure in human beings

Dodt, Christoph; Hallschmid, Manfred; Lepiorz, Marc; Fehm, Horst L.; Born, Jan; Kern, Werner

doi:10.1016/j.metabol.2005.04.026

Cited by 34 publications

(24 citation statements)

References 61 publications

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“…Since animal experiments have indicated that central nervous insulin can induce acute sympathoexcitation via central nervous autonomous centers [34], the possible therapeutic use of intranasal insulin administration might be hampered by elevating effects on blood pressure. However, with long-term intranasal treatment we did not find any hints towards an elevating effect of insulin on blood pressure in humans [35]. These findings fit well with animal studies indicating that long-term in contrast to immediate central nervous insulin administration does not affect arterial blood pressure [34,36,37,38].…”

Section: Intranasal Administration Of Insulinsupporting

confidence: 79%

Intranasal Insulin to Improve Memory Function in Humans

Benedict¹,

Hallschmid²,

Schultes

et al. 2007

Neuroendocrinology

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152

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Background: Compelling evidence indicates that central nervous insulin enhances learning and memory and in particular benefits hippocampus-dependent (i.e., declarative) memory. Intranasal administration of insulin provides an effective way of delivering the compound to the central nervous system, bypassing the blood-brain barrier and avoiding systemic side effects. Methods: Here we review a series of recent studies on the effects of intranasally administered insulin on memory functions in humans. In accordance with the beneficial effects of intravenously administered insulin on hippocampus-dependent declarative memory observed in hyperinsulinemic-euglycemic clamp studies, intranasal insulin administration similarly improves this type of memory, but in the absence of adverse peripheral side effects. Result andConclusion: Considering that cerebrospinal fluid insulin levels are reduced in patients suffering from Alzheimer’s disease, these results may be of considerable relevance for future clinical applications of insulin in the treatment of memory disorders.

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Section: Intranasal Administration Of Insulinsupporting

confidence: 79%

Intranasal Insulin to Improve Memory Function in Humans

Benedict¹,

Hallschmid²,

Schultes

et al. 2007

Neuroendocrinology

Self Cite

152

View full text Add to dashboard Cite

show abstract

“…24 Interactions with signals like atrial natriuretic peptide that are assumed to inhibit hypothalamic ACTH release may add to this effect. 25 As observed in normalweight men, 16,26 the transient increase in systolic blood pressure after acute insulin administration vanished during long-term treatment.…”

Section: Discussionmentioning

confidence: 88%

Obese men respond to cognitive but not to catabolic brain insulin signaling

et al. 2007

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Context and objective: Insulin acts in the brain to reduce food intake and body weight and is considered a major adiposity signal in energy homeostasis. In normal-weight men, intranasal insulin administration reduces body fat and improves declarative memory. The present experiments aimed to generalize these findings to obese patients, with a view to evaluate the therapeutic potential of the compound. Design, subjects and measurements: Insulin and placebo, respectively, were intranasally administered four times a day (amounting to 160 IU day À1 ) over 8 weeks to two groups of 15 obese men each. Results: Contrasting with the catabolic effects in normal-weight men, insulin treatment did not induce any significant reduction of body weight (P40.50) and body fat (P40.44) in the obese subjects. However, in accordance with the effects in normalweight men, declarative memory and mood were improved (Po0.05) and hypothalamic-pituitary-adrenal axis activity as assessed by circulating ACTH (Po0.01) and cortisol levels (Po0.04) was reduced. Conclusions: Our results indicate that in obese men, intranasal insulin is functionally active in the central nervous system but fails to affect the neuronal networks critically involved in body weight regulation. We conclude that obesity in men is associated with central nervous resistance to the adiposity signal insulin. This defect likely contributes to the persistence of obesity in spite of elevated levels of circulating insulin in obese patients.

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“…Recently, nasal insulin application was demonstrated to influence noradrenaline (norepinephrine) levels, an indicator of sympathetic nervous system activity [47]. However, a smaller study found no effect of intranasal insulin on muscular sympathetic nervous activity [48]. Given these data, the autonomous nervous system might be involved in the insulin-induced central regulation of peripheral insulin sensitivity.…”

Section: Discussionmentioning

confidence: 99%

Nasal insulin changes peripheral insulin sensitivity simultaneously with altered activity in homeostatic and reward-related human brain regions

et al. 2012

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Aims/hypothesis Impaired insulin sensitivity is a major factor leading to type 2 diabetes. Animal studies suggest that the brain is involved in the regulation of insulin sensitivity. We investigated whether insulin action in the human brain regulates peripheral insulin sensitivity and examined which brain areas are involved. Methods Insulin and placebo were given intranasally. Plasma glucose, insulin and C-peptide were measured in 103 participants at 0, 30 and 60 min. A subgroup (n012) was also studied with functional MRI, and blood sampling at 0, 30 and 120 min. For each time-point, the HOMA of insulin resistance (HOMA-IR) was calculated as an inverse estimate of peripheral insulin sensitivity.

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Immediate but not long-term intranasal administration of insulin raises blood pressure in human beings

Cited by 34 publications

References 61 publications

Intranasal Insulin to Improve Memory Function in Humans

Intranasal Insulin to Improve Memory Function in Humans

Obese men respond to cognitive but not to catabolic brain insulin signaling

Nasal insulin changes peripheral insulin sensitivity simultaneously with altered activity in homeostatic and reward-related human brain regions

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