Immediate and long-term effects of glucomannan on total ghrelin and leptin in type 2 diabetes mellitus

Chearskul, Sanay; Kriengsinyos, Wantanee; Kooptiwut, Suwattanee; Sangurai, S.; Onreabroi, Smarn; Churintaraphan, Malika; Semprasert, Namoiy; Nitiyanant, Wannee

doi:10.1016/j.diabres.2008.11.014

Cited by 18 publications

(14 citation statements)

References 9 publications

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“…Konjac glucomannan supplement significantly increased the weekly defecation frequency by 30% (from 4.1 to 5.3 per week) and fecal dry weight (3.7 g/day) with reduced severity of stomach wind (Chen et al, 2008). The effectiveness of glucomannan as a supplementary treatment to type 2 diabetes mellitus in association with the simultaneous changes of ghrelin and leptin hormones was evaluated by Chearskul et al (2008), through a randomized, controlled trail in 20 type 2 diabetic patients. Each subject received 1 g encapsulated glucomannan or white rice flour 30 min prior to standard OGTT on separate occasions after a 2-week and then 4-week period when consuming 1 g glucomannan or white rice before the 3 meals of the day on these hormones.…”

Section: Anti-diabetic Effectmentioning

confidence: 99%

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Health benefits of konjac glucomannan with special focus on diabetes

Shah

Wang

et al. 2015

Bioactive Carbohydrates and Dietary Fibre

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Section: Anti-diabetic Effectmentioning

confidence: 99%

“…Glucomannan enhanced prandial ghrelin reduction when given before glucose load and impeded the rise of fasting ghrelin after 4-week supplement. Ghrelin-induced feeding may be attenuated by glucomannan (Chearskul et al, 2008).…”

Section: Anti-diabetic Effectmentioning

confidence: 99%

Health benefits of konjac glucomannan with special focus on diabetes

Shah

Wang

et al. 2015

Bioactive Carbohydrates and Dietary Fibre

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“…Since, glucomannan cannot affect gut hormone response [9–13] and similarly, phaseolamin does not affect gut hormone-mediated appetite modulation because it blocks amylase in the digestion of complex carbohydrates (starch), the discussion will focus on the different protein compositions of the supplement [14–17]. …”

Section: Discussionmentioning

confidence: 99%

“…More than 20 different regulatory peptide hormones are released in the gastrointestinal system. Many of them are involved in regulating food intake and are sensitive to content and composition of intestinal nutrients [9]. A number of them respond after protein consumption and this may account for food intake suppression after milk protein ingestion.…”

Section: Introductionmentioning

confidence: 99%

Appetite control and gastrointestinal hormonal behavior (CCK, GLP-1, PYY 1–36) following low doses of a whey protein-rich nutraceutic

Sukkar

Vaccaro

Ravera³

et al. 2013

Mediterr J Nutr Metab

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Whey proteins represent the most satiating nutrients. In particular, their effects are due to enterohormonal changes (CCK, GLP-1 and PYY 1–36) observed after their exclusive ingestion. Glucomannan has important satiety property due to volume increase following gelification. The aim of the study is the evaluation of subjective rate of hunger and enterohormone concentrations (CCK, GLP-1, PYY 1–36) following oral loading of a mixture containing WP (8 g) or casein (8 g) plus glucomannan (1 g) (Colordiet®, Inpha DUEMILA Srl Lecco, Italy). The study was conducted as a double-blind crossover with five healthy volunteers (BMI 22–26 kg/m2 aging 18–65 years) in acute and a wash-out period of 1 week between the first and the second evaluation. From the analysis of the data, we observe that the load with WP induces a significant decrease in the desire to eat after 90 min (P < 0.0446) when compared with casein. As far as plasma hormones are concerned, there was a significant increase only in GLP-1 at 90 min after WP (P < 0.00166) and 180 min after casein (T0 vs. T180 P = 0.000129). There is a significant correlation between the increase in GLP-1 and decrease of desire to eat (R = −0.93). There is a tendency to the increasing of CCK after 90 min, which is not significant (P = 0.091). These results could be due to (a) the low number of cases or (b) the low dose of protein used. The present study suggests that a mixture of WP plus glucomannan exerts a decrease in the desire to eat which is correlated to enterohormonal modification (GLP-1 increase) despite the low content of protein (8 g) and the presence of glucomannan, which could reduce the fast absorption of WP in relation to the net forming during the gelification of the gastric environment.

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“…Glucomannan (soluble fiber) as a supplementary treatment slowed carbohydrate absorption, enhanced prandial ghrelin reduction when given before a glucose load, and impeded the rise of fasting ghrelin after 4-week supplementation (Chearskul et al, 2009). Nutraceuticals already marketed are guar gum and chromium picolinate.…”

Section: Nutraceuticalsmentioning

confidence: 99%

Novel Pharmacological Approaches to the Treatment of Type 2 Diabetes

Verspohl

2012

Pharmacol Rev

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Immediate and long-term effects of glucomannan on total ghrelin and leptin in type 2 diabetes mellitus

Cited by 18 publications

References 9 publications

Health benefits of konjac glucomannan with special focus on diabetes

Health benefits of konjac glucomannan with special focus on diabetes

Appetite control and gastrointestinal hormonal behavior (CCK, GLP-1, PYY 1–36) following low doses of a whey protein-rich nutraceutic

Novel Pharmacological Approaches to the Treatment of Type 2 Diabetes

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