Immediate and delayed anxiety- and depression-like profiles in the adolescent Wistar-Kyoto rat model of endogenous depression following postweaning social isolation

Shetty, Reshma A.; Sadananda, Monika

doi:10.1016/j.bbr.2016.12.030

Cited by 20 publications

(27 citation statements)

References 67 publications

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“…Closed arm time (%) results showed a significant main effect for strain (F (1,14) = 15.03; p = 0.0017) with WKYs demonstrating significant increased ( p < 0.05) closed arm time in the P + E phase when compared to Wistars. A significant main effect for phase (F (1,14) = 61.74; p < 0.0001) was also observed with WKYs demonstrating a significant ( p < 0.001) increase in closed arm time during the P + E phase, while Wistars demonstrated a significant ( p < 0.001) decrease on testing in the same phase (2-way ANOVA: strain × phase interaction: F (1,14) = 0.27; p = 0.6129).…”

Section: Open/closed Arm Timementioning

confidence: 93%

“…A significant main effect for phase (F (1,14) = 61.74; p < 0.0001) was also observed with WKYs demonstrating a significant ( p < 0.001) increase in closed arm time during the P + E phase, while Wistars demonstrated a significant ( p < 0.001) decrease on testing in the same phase (2-way ANOVA: strain × phase interaction: F (1,14) = 0.27; p = 0.6129). *** Indicates significant differences between the strains -Wistar (WIS) and Wistar Kyoto (WKY) during diestrus (D1 + D2) and proestrusestrus (P + E) phases of estrous cycle.…”

Section: Open/closed Arm Timementioning

confidence: 99%

“…In the FST, the time spent by the animals in passive behavior (floating) called immobility, which was defined as the lack of motion of the whole body, and active behaviors (swimming and climbing) along with the latency to the first immobility were scored automatically in real time by the system during data acquisition. Ethovision settings that differentiated between immobility, swimming, and climbing behaviors have been validated manually [14,17,36] .…”

Section: Forced Swim Testmentioning

confidence: 99%

“…Water was filled up to 32 cm from the base with water temperature maintained between 25 and 28 ° C. FST was carried out as per the procedure previously described [34,35] with minor modifications [14,17] . The procedure consisted of 2 days of testing.…”

Section: Forced Swim Testmentioning

confidence: 99%

“…As most animal studies on depression and anxiety use males [14] , due to the variability of female behavioral and brain data induced by inherent hormonal fluxes [15] , limited insights have been gained into stress-reactivity, depression, and anxiety profiles in females [16] . Furthermore, most female studies have used adults [3] .…”

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confidence: 99%

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Estrous Cycle Phase-Dependent Changes in Anxiety- and Depression-Like Profiles in the Late Adolescent Wistar-Kyoto Rat

D'Souza

Sadananda²

2017

Ann Neurosci

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Background: Depression often manifests during adolescence when the development and networking of social and emotional brain areas is being influenced by hormones. The Wistar Kyoto (WKY) rat has been proposed as an animal model of adolescent depression with various face, construct, and predictive validities for clinical depression having been established. Purpose: The influence of the estrous cycle on anxiety- and depression-like behaviors in female adolescents may be tested out further using this model. Methods: Female adolescent WKY rats were tested for anxiety- and depression-like behaviors in the elevated plus maze and forced swim test (FST) during different phases of the estrous cycle with inbred, age-, and phase-matched Wistar rats as controls. Results: Wistars in proestrus-estrus demonstrated reduced anxiety levels. WKY also demonstrated increased open arm time and entries and closed arm time, but less than Wistars, and as closed arm entries remained unaffected, it did not translate into a lowering of the anxiety levels. Risk taking and risk assessment behaviors were not affected by estrous phases in WKY, though exploratory behavior was reduced in proestrus-estrus. In Wistars, increased risk taking and decreased risk assessment behaviors were observed during proestrus-estrus. Increased immobility in the FST, indicative of learned helplessness was not influenced by phase in the WKY, which was at variance with Wistars that demonstrated phase-specific differences. Conclusion: Results indicate a masking effect of indicative hormones in this putative model of adolescent depression, with implications for an unravelling of the steroid milieu in predisposed adolescent depression and for taking phase-specific time windows into account for therapeutic interventions.

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Section: Open/closed Arm Timementioning

confidence: 93%

Section: Open/closed Arm Timementioning

confidence: 99%

Section: Forced Swim Testmentioning

confidence: 99%

Section: Forced Swim Testmentioning

confidence: 99%

mentioning

confidence: 99%

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Estrous Cycle Phase-Dependent Changes in Anxiety- and Depression-Like Profiles in the Late Adolescent Wistar-Kyoto Rat

D'Souza

Sadananda²

2017

Ann Neurosci

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Brief Social Isolation in the Adolescent Wistar-Kyoto Rat Model of Endogenous Depression Alters Corticosterone and Regional Monoamine Concentrations

Shetty

Sadananda

2017

Neurochem Res

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The Wistar-Kyoto rat (WKY) model has been suggested as a model of adult and adolescent depression though face, predictive and construct validities of the model to depression remain equivocal. The suitability of the WKY as a diathesis model that tests the double-hit hypothesis, particularly during critical periods of brain and behavioural development remains to be established. Here, effects of post-weaning social isolation were assessed during early adolescence (~30pnd) on behavioural despair and learned helplessness in the forced swim test (FST), plasma corticosterone levels and tissue monoamine concentrations in brain areas critically involved in depression, such as prefrontal cortex, nucleus accumbens, striatum and hippocampus. Significantly increased immobility in the FST was observed in socially-isolated, adolescent WKY with a concomitant increase in corticosterone levels over and above the FST-induced stress. WKY also demonstrated a significantly increased release and utilization of dopamine, as manifested by levels of metabolites 3,4-dihydroxyphenylacetic acid and homovanillic acid in nucleus accumbens, indicating that the large dopamine storage pool evident during adolescence induces greater dopamine release when stimulated. The serotonin metabolite 5-hydroxy-indoleacetic acid was also significantly increased in nucleus accumbens, indicating increased utilization of serotonin, along with norepinephrine levels which were also signficantly elevated in socially-isolated adolescent WKY. Differences in neurochemistry suggest that social or environmental stimuli during critical periods of brain and behavioural development can determine the developmental trajectories of implicated pathways.

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The role of gender differences in the outcome of juvenile social isolation: Emphasis on changes in behavioral, biochemical and expression of nitric oxide synthase genes alteration

Bijani,

Kashfi,

Zahedi-Vanjani

et al. 2024

Heliyon

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Immediate and delayed anxiety- and depression-like profiles in the adolescent Wistar-Kyoto rat model of endogenous depression following postweaning social isolation

Cited by 20 publications

References 67 publications

Estrous Cycle Phase-Dependent Changes in Anxiety- and Depression-Like Profiles in the Late Adolescent Wistar-Kyoto Rat

Estrous Cycle Phase-Dependent Changes in Anxiety- and Depression-Like Profiles in the Late Adolescent Wistar-Kyoto Rat

Brief Social Isolation in the Adolescent Wistar-Kyoto Rat Model of Endogenous Depression Alters Corticosterone and Regional Monoamine Concentrations

The role of gender differences in the outcome of juvenile social isolation: Emphasis on changes in behavioral, biochemical and expression of nitric oxide synthase genes alteration

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