Immediate and delayed allergy from epoxy resins based on diglycidyl ether of bisphenol A.

Health hazard evaluation report: an evaluation of respiratory health at a syntactic foam manufacturing facility.

“…We know that many causes of allergic asthma exist in the facility. Exposure to epoxy resin systems containing ingredients such as amines, bisphenol A diglycidyl ether, and anhydrides including methyltetrahydrophthalic anhydride can cause allergic reactions (both immediate and delayed), dermatitis, and asthma [Fawcett et al 1977;Nielsen et al 1989;Kanerva et al 1991;Nielsen et al 1992;Patussi et al 1995;Yokota et al 1999;Nielsen et al 2001;Yokota et al 2002;Nielsen et al 2006;Hannu et al 2009;Helaskoski et al 2009;Malo and Chan-Yeung 2009;Foti et al 2010]. In addition to allergic sensitizers, workers may have been exposed to irritant causes of work-related asthma such as butanediol diglycidyl ether, aliphatic amines, anhydrides, bisphenol A, epichlorohydrin, and milled fibers.…”

Occupational Allergic Contact Dermatitis and Asthma due to a Single Low Molecular Weight Agent

“…On the other hand, respiratory hypersensitivity induced by epoxy resins has rarely been described. In 1991, in Helsinki, Kanerva et al published two cases of asthma to DGEBA, but did not do any worksimulated bronchial provocation test 30) . Concerning both dermatitis and asthma from epoxy resins, only one case was reported by Kanerva et al in 2000 16) , a 26-yr-old concrete worker who developed contact hypersensitivity and, 5 yr later, an OA from cement containing DGEBA.…”

Evaluation of the responses of MHC class II molecule-expressing cells and macrophages to epoxy resin-based and 4-META-containing, methacrylate resin-based root canal sealers in rat subcutaneous tissue

“…These components might also directly or indirectly induce MHC class II molecule expression on macrophages, thereby leading these cells to acquire antigen presentation capacity 26) . Bisphenol-A-diglycidyl ether, a base resin of AH Plus, had reportedly caused immediate and delayed allergic reactions after occupational exposure to this chemical 36) . The understanding of the response of MHC class II moleculeexpressing cells to a sealer could be refined by evaluating their responses to individual sealer components.…”