Immature platelet fraction (IPF) in hospitalized patients with neutrophilia and suspected bacterial infection

Mario, Antonella Di; Garzia, Mariagrazia; Leone, Fiammetta; Arcangeli, A; Pagano, Livio; Zini, Gina

doi:10.1016/j.jinf.2009.07.007

Cited by 32 publications

(23 citation statements)

References 28 publications

(20 reference statements)

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“…Under conditions such as those under which the PBSCs are mobilized, the reticulated platelet count might be increased at a different time from that at which the PBSC count is increased. Several reports have shown an increase in the immature platelet count in patients with thrombotic disease without thrombocytosis [20]; with acute coronary syndromes, especially those in the acute phase of myocardial infarction [21]; and with neutrophilia and severe bacterial infection [22]. Our patients had never suffered from obvious thromboembolic disease and severe infectious disease during PBSC collection, but their reticulated platelet count could have been influenced by other factors, such as vascular damage.…”

Section: Discussionmentioning

confidence: 69%

Hematopoietic progenitor cell count, but not immature platelet fraction value, predicts successful harvest of autologous peripheral blood stem cells

Mitani

Yujiri

Tanaka

et al. 2010

J of Clinical Apheresis

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Mobilized stem cells in the peripheral blood (PB) must be efficiently harvested at the appropriate time before autologous PB stem cell (PBSC) transplantation. Enumeration of CD34+ cells in the PB before apheresis predicts the number of PBSCs that can be collected, but the cytometric techniques used are complex and expensive. Therefore, it is necessary to identify an alternative to the CD34+ cell count in PBSC harvest-time monitoring. Fully automated flow cytometry using blood cell counters now allows reliable quantification of immature myeloid cells in the PB, referred to as hematopoietic progenitor cells (HPC), and reticulated platelets, expressed as the immature platelet fraction (IPF). Immature or reticulated platelets are thought to correlate with thrombopoietic activity of the marrow. Following a chemotherapy nadir, the recovery of white blood cell and platelet counts has been used to determine the right time for apheresis. Therefore, we examined whether the HPC count and IPF value could be used to predict PBSC mobilization in 20 patients with hematological malignancies. The HPC count was found to be correlated with the CD34+ cell count (r = 0.84, P < 0.01), whereas the IPF value was not (r = 0.37, P = 0.44). Therefore, the HPC count, but not the IPF value, is a possible predictor of the timing of autologous stem cell transplantation.

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Section: Discussionmentioning

confidence: 69%

Hematopoietic progenitor cell count, but not immature platelet fraction value, predicts successful harvest of autologous peripheral blood stem cells

Mitani

Yujiri

Tanaka

et al. 2010

J of Clinical Apheresis

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“…In other studies, an increased IPF was related to suspected bacterial infection and the severity of sepsis [15,27]. Although none of those studies examined the coagulation profile of participants in detail, IPF elevation suggested the onset of severe infection or sepsis.…”

Section: Accepted Manuscriptmentioning

confidence: 96%

Immature platelet fraction predicts coagulopathy-related platelet consumption and mortality in patients with sepsis

Muronoi

Koyama

Nunomiya

et al. 2016

Thrombosis Research

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“…The immature platelet fraction (IPF) is routinely reported as percentage of the total platelet count (%IPF) or for research purpose also as absolute numbers (a‐IPF), indicating the degree of destruction and production of platelets, respectively . Alterations in %IPF or a‐IPF have been reported in bacterial and viral infections . In contrast, increments in IG have only been reported in bacterial infections and, to the best of our knowledge, have not been studied in viral infections, and as such also not in studies comparing viral and bacterial infections.…”

Section: Introductionmentioning

confidence: 99%

New parameters available on Sysmex XE‐5000 hematology analyzers contribute to differentiating dengue from leptospirosis and enteric fever

Oehadian

Michels

Mast

et al. 2015

Int J Lab Hematology

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Immature platelet fraction (IPF) in hospitalized patients with neutrophilia and suspected bacterial infection

Cited by 32 publications

References 28 publications

Hematopoietic progenitor cell count, but not immature platelet fraction value, predicts successful harvest of autologous peripheral blood stem cells

Hematopoietic progenitor cell count, but not immature platelet fraction value, predicts successful harvest of autologous peripheral blood stem cells

Immature platelet fraction predicts coagulopathy-related platelet consumption and mortality in patients with sepsis

New parameters available on Sysmex XE‐5000 hematology analyzers contribute to differentiating dengue from leptospirosis and enteric fever

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