Immature (malignant) teratoma of the ovary.A clinical and pathologic study of 58 cases

Norris, Henry J.; Zirkin, Howard J.; Benson, William L.

doi:10.1002/1097-0142(197605)37:5<2359::aid-cncr2820370528>3.0.co;2-q

Cited by 581 publications

(87 citation statements)

References 10 publications

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“…The quantity of immature neural tissue alone determines the grade. [4] Therapy consists of unilateral salpingo-oophorectomy with wide sampling of peritoneal implants. If the tumor if confined to the ovary and grade I, no further therapy is needed.…”

Section: Introductionmentioning

confidence: 99%

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Characteristics, treatment and outcomes of women with immature ovarian teratoma, 1998–2012

Jorge

Jones

Chen

et al. 2016

Gynecologic Oncology

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Objective To explore the presentation, management and outcomes of adult women diagnosed with immature ovarian teratoma. Methods The National Cancer Database (NCDB) was used to identify women ≥18 years of age diagnosed with an immature teratoma from 1998–2012. We analyzed demographic, clinical and tumor characteristics, and treatment trends. Multivariable models were employed to examine predictors of adjuvant chemotherapy use and survival. Results We identified a total of 1045 adult women with immature teratoma. The median age of diagnosis was 27 years and most were diagnosed between ages 18 and 39 (88.9%). The majority presented with early-stage (I/II) disease (76.0%), underwent unilateral salpingo-oophorectomy (52.5%) and received adjuvant chemotherapy (56.8%). The probability of receiving chemotherapy increased with stage, grade, and treatment at academic compared to community based centers (P<0.05.). Older age, advanced stage, and grade III histology were associated with worse survival (P<0.05). Five-year survival rates were: 98.3% (95% CI 96.8–99.1), 93.2% (95% CI 82.8–97.4), 82.7% (95% CI 74.3–88.5), and 72.0% (95% CI,50.1–85.5) for stages I, II, III, and IV disease, respectively. Conclusions The incidence of immature teratoma is highest in young adults aged 18 to 39. Most patients present with early-stage disease, are managed with fertility sparing surgery and chemotherapy and have an excellent prognosis. Later age at diagnosis, advanced stage, and high-grade histology confer a worse prognosis.

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Section: Introductionmentioning

confidence: 99%

“…[5] Treatment with surgery followed by systemic chemotherapy can achieve remission and cure in over 90% of cases. [3, 4]…”

Section: Introductionmentioning

confidence: 99%

Characteristics, treatment and outcomes of women with immature ovarian teratoma, 1998–2012

Jorge

Jones

Chen

et al. 2016

Gynecologic Oncology

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“…Abdominal pain associated with a palpable abdominopelvic mass is observed in almost all patients. 13 Malignant ovarian germ cell tumours affect generally adolescent and young women with a peak incidence around 20years. 14 In the present study median age was 21 years and about 10% of patients were older than 30 years.…”

Section: Discussionmentioning

confidence: 99%

Treatment outcomes in malignant ovarian germ cell tumors

Kumar

2017

Int J Reprod Contracept Obstet Gynecol

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Background: Malignant ovarian germ cell tumours are rare group of ovarian neoplasms derived from primordial germ cells of the ovary. Objective of present study was to evaluate the outcome of treatment in malignant germ cell tumours.Methods: 21 Patients of malignant ovarian germ cell tumours registered at Department of Medical Oncology, Institute of Obstetrics and Gynaecology, Chennai for the period from January 2012 to December 2015 were retrospectively analyzed for treatment outcomes.Results: The median age at presentation was 21 years with age range between 14 and 40 years. 9patients (43%) presented with mixed germ cell tumour, 6 patients (29%) with dysgerminoma, 3 patients (14%) with yolk sac tumour and 3 patients (14%)with mature cystic teratoma. 13 patients (62%) presented with Stage I disease, 5 patients (24%) with Stage III and 3 patients (14%) with Stage II. Fertility sparing surgery was done in 15 patients (71%), and 4 patients (19%) who completed family had TAH with BSO done. Adjuvant Chemotherapy was given for 16 patients (76%) and as Neoadjuvant in 2patients (10%) who had biopsy alone performed. 4patients (19%) developed recurrence and was taken for salvage PVI chemotherapy.Conclusions: Malignant ovarian germ cell tumours are relatively uncommon neoplasms characterized by high chemo sensitivity. This study confirms that malignant ovarian germ cell tumours have excellent prognosis and the effectiveness of BEP chemotherapy regimen. Fertility sparing surgery is feasible in most cases. Advanced Stage configured as an important risk factor for survival. The chemotherapy regimen was associated with significant but manageable toxicity.

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“…They found that the 5-year overall survival rate for patients with immature teratoma of stage I and G1 was 98.5% if they underwent cystectomy without residual tumor. Norris et al reported that the rate of recurrence of immature teratoma was 18% in G1, 37% in G2, and 70% in G3, but the 5-year overall survival of patients with stage I and G1 tumors was 100% in 14 cases 13. Generally, immature teratoma patients of stage I and G1 are treated with surgery alone, because the prognosis is good.…”

Section: Discussionmentioning

confidence: 99%

Three Cases of Immature Teratoma Diagnosed after Laparoscopic Operation

Nishida

Kawano

Yuge

et al. 2014

Clin Med Insights Case Rep

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While mature cystic teratoma of the ovary is the most common ovarian tumor in young women, immature teratoma is a very rare tumor, representing only 1% of all ovarian cancers. In the three cases presented here, young women who were suspected to have mature cystic teratoma, based on CT scan and MRI, were ultimately diagnosed with immature teratoma Ic (b) G1 after laparoscopic operation. They underwent salpingo-oophorectomy of the affected side only and have shown no sign of recurrence during follow-up. We sometimes encounter patients with immature teratoma who have no findings pointing to malignancy on CT or MRI. Generally, if the components of immature nerve cells that represent immature teratoma are very few, it is difficult to diagnose the entity as immature teratoma with imaging evaluations such as CT or MRI. In many hospitals, laparoscopic surgery is selected for patients with ovarian mature teratoma. Therefore, it is essential to attempt as much as possible not to disseminate the fluid content of the tumor into the intra-abdominal space during laparoscopic operation, because in rare cases the tumor turns out not to be benign mature teratoma.

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Immature (malignant) teratoma of the ovary.A clinical and pathologic study of 58 cases

Cited by 581 publications

References 10 publications

Characteristics, treatment and outcomes of women with immature ovarian teratoma, 1998–2012

Characteristics, treatment and outcomes of women with immature ovarian teratoma, 1998–2012

Treatment outcomes in malignant ovarian germ cell tumors

Three Cases of Immature Teratoma Diagnosed after Laparoscopic Operation

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