Imiquimod and 5% Fluorouracil Therapy for Anal and Perianal SquamousCell Carcinoma In Situ in an HIV-1–Positive Man

Intra-anal use of imiquimod: what is the clinical evidence?

“…The search performed in PubMed and Scopus retrieved a total of 177 and 231 search results, respectively, among which 14 studies (three randomized controlled trials, five retrospective studies, four prospective studies, and two case reports) were identified as eligible for inclusion in this review. [8][9][10][11][12][13][14][15][16][17][18][19][20][21] Among the included studies, two additional articles were identified through hand-searching of references. Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed for carrying out this systematic review.…”

Pigmented Bowen's disease of the penis and scrotum in a patient with AIDS

“…Treatment options for HIV-infected patients with Bowen's disease include 5-Fluorouracil 5% cream, imiquimod 5% cream, radiation or excision [10,11,12]. Excision margins within few millimeters of the tumor edge provides oncological control with a 4 % recurrence rate in invasive penile squamous cell carcinomas stages T1-T3 [14].…”

Treatment-Refractory Actinic Keratoses Successfully Treated Using Simultaneous Combination Topical 5-Fluorouracil Cream and Imiquimod Cream: A Case–Control Study

“…Imiquimod and 5‐FU have been reported to be effective in combination for treating cutaneous SCC in situ . Imiquimod, a toll‐like receptor (TLR) agonist with specific binding to TLR‐7 and TLR‐8, has demonstrated antitumor and antiviral activity in animals and humans .…”

“…Imiquimod and 5-FU have been reported to be effective in combination for treating cutaneous SCC in situ. [12][13][14] Imiquimod, a toll-like receptor (TLR) agonist with specific binding to TLR-7 and TLR-8, has demonstrated antitumor and antiviral activity in animals and humans. [15][16][17] These effects are partly due to production of proinflammatory cytokines induced through the innate immune system and the cellular arm of acquired immunity and include interferon (IFN)-alpha, IFN-gamma, and interleukin (IL)-12, among others.…”