Imbalance of gut microbiota and fecal metabolites in offspring female mice induced by nitenpyram exposure during pregnancy

Yan, Sen; Tian, Sinuo; Meng, Zhiyuan; Yan, Jin; Jia, Ming; Li, Ruisheng; Zhou, Zhiqiang; Zhu, Wentao

doi:10.1016/j.chemosphere.2020.127506

Cited by 24 publications

(16 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Disrupted gut microbial communities have long been demonstrated to be the pathological mediators of many diseases (66,67). Microorganisms such as bacteria, fungi, protozoa, and viruses in the intestine interact in a synergistic, antagonistic, or symbiotic relationship to form a stable intestinal environment (68).…”

Section: Discussionmentioning

confidence: 99%

Microbiome Analysis Reveals the Dynamic Alternations in Gut Microbiota of Diarrheal Giraffa camelopardalis

Song

Qin

et al. 2021

Front. Vet. Sci.

View full text Add to dashboard Cite

The ruminant gut microbial community's importance has been widely acknowledged due to its positive roles in physiology, metabolism, and health maintenance. Diarrhea has been demonstrated to cause adverse effects on gastrointestinal health and intestinal microecosystem, but studies regarding diarrheal influence on gut microbiota in Giraffa camelopardalis have been insufficient to date. Here, this study was performed to investigate and compare gut microbial composition and variability between healthy and diarrheic G. camelopardalis. The results showed that the gut microbial community of diarrheal G. camelopardalis displayed a significant decrease in alpha diversity, accompanied by distinct alterations in taxonomic compositions. Bacterial taxonomic analysis indicated that the dominant bacterial phyla (Proteobacteria, Bacteroidetes, and Firmicutes) and genera (Escherichia Shigella and Acinetobacter) of both groups were the same but different in relative abundance. Specifically, the proportion of Proteobacteria in the diarrheal G. camelopardalis was increased as compared with healthy populations, whereas Bacteroidetes, Firmicutes, Tenericutes, and Spirochaetes were significantly decreased. Moreover, the relative abundance of one bacterial genus (Comamonas) dramatically increased in diarrheic G. camelopardalis, whereas the relative richness of 18 bacterial genera decreased compared with healthy populations. Among them, two bacterial genera (Ruminiclostridium_5 and Blautia) cannot be detected in the gut bacterial community of diarrheal G. camelopardalis. In summary, this study demonstrated that diarrhea could significantly change the gut microbial composition and diversity in G. camelopardalis by increasing the proportion of pathogenic to beneficial bacteria. Moreover, this study first characterized the distribution of gut microbial communities in G. camelopardalis with different health states. It contributed to providing a theoretical basis for establishing a prevention and treatment system for G. camelopardalis diarrhea.

show abstract

Section: Discussionmentioning

confidence: 99%

Microbiome Analysis Reveals the Dynamic Alternations in Gut Microbiota of Diarrheal Giraffa camelopardalis

Song

Qin

et al. 2021

Front. Vet. Sci.

View full text Add to dashboard Cite

show abstract

“…Several studies suggested that long-term exposure can lead to impairment of the gut microbial in bees with a reduced abundance of total bacterial flora, mainly Firmicutes [ 82 , 83 , 84 , 85 , 86 ]. In pregnant mice, nitenpyram also altered lipid metabolism and decreased the abundance of Proteobacteria , specifically of the Desulfovibrionaceae family [ 87 ], and IMI was shown to reduce liver weights and alter the histological structure of hepatic tissue, disrupting the gut microbial composition with consequently impaired barrier function [ 88 ]. Hong et al evaluated the effects of IMI in crab, ‘ Erocheir sinensis ’.…”

Section: Insecticidesmentioning

confidence: 99%

Toxicology and Microbiota: How Do Pesticides Influence Gut Microbiota? A Review

Giambò

Teodoro

Costa

et al. 2021

IJERPH

View full text Add to dashboard Cite

In recent years, new targets have been included between the health outcomes induced by pesticide exposure. The gastrointestinal tract is a key physical and biological barrier and it represents a primary site of exposure to toxic agents. Recently, the intestinal microbiota has emerged as a notable factor regulating pesticides’ toxicity. However, the specific mechanisms related to this interaction are not well known. In this review, we discuss the influence of pesticide exposure on the gut microbiota, discussing the factors influencing gut microbial diversity, and we summarize the updated literature. In conclusion, more studies are needed to clarify the host–microbial relationship concerning pesticide exposure and to define new prevention interventions, such as the identification of biomarkers of mucosal barrier function.

show abstract

“…Likewise, the toxic endpoints regarding the adverse effects of xenobiotics on the intestinal microbiota are included in many toxicity test systems [ 22 , 23 ]. Intriguingly, environmental exposures during pregnancy are also able to disrupt the gut microbiome of offspring [ 24 , 25 ], which may further lead to unpredictable impact on their postnatal development. Nevertheless, the role of gut microbiota in the pregnancy exposed TiO 2 NPs-induced neurodevelopmental toxicity remains largely unknown.…”

Section: Introductionmentioning

confidence: 99%

Pregnancy exposure of titanium dioxide nanoparticles causes intestinal dysbiosis and neurobehavioral impairments that are not significant postnatally but emerge in adulthood of offspring

Duan

Qiu

et al. 2021

J Nanobiotechnol

View full text Add to dashboard Cite

Background Pregnancy exposure to titanium dioxide nanoparticles (TiO2NPs) is a vital consideration due to their inadvertent ingestion from environmental contamination. The potential health effects of TiO2NPs on the neurodevelopmental process should be seriously concerned in health risk assessment, especially for the pregnant women who are susceptible to the neurodevelopmental toxicity of nano-sized particles. However, the available evidence of neurodevelopmental toxicity of TiO2NPs remains very limited. Methods In the present study, the pregnant mice were intragastric administered with 150 mg/kg TiO2NPs from gestational day (GD) 8 to 21, the maternal behaviors and neurodevelopment-related indicators in offspring were all assessed at different time points after delivery. The gut microbial community in both dams and their offspring were detected by using 16S ribosomal RNA (rRNA) gene sequencing. The gut-brain axis related indicators were also determined in the offspring. Results The results clearly demonstrated that exposure to TiO2NPs did not affect the maternal behaviors of pregnant mice, or cause the deficits on the developmental milestones and perturbations in the early postnatal development of offspring. Intriguingly, our data revealed that pregnancy exposure of TiO2NPs did not affect locomotor function, learning and memory ability and anxiety-like behavior in offspring at postnatal day (PD) 21, but resulted in obvious impairments on these neurobehaviors at PD49. Similar phenomena were obtained in the composition of gut microbial community, intestinal and brain pathological damage in offspring in adulthood. Moreover, the intestinal dysbiosis induced by TiO2NPs might be highly associated with the delayed appearance of neurobehavioral impairments in offspring, possibly occurring through disruption of gut-brain axis. Conclusions This is the first report elucidated that pregnancy exposure to TiO2NPs caused delayed appearance of neurobehavioral impairments in offspring when they reached adulthood, although these perturbations did not happen at early life after delivery. These findings will provide valuable insights about neurodevelopmental toxicity of TiO2NPs, and call for comprehensive health risk assessment of TiO2NPs on the susceptible population, such as pregnant women. Graphical abstract

show abstract

Imbalance of gut microbiota and fecal metabolites in offspring female mice induced by nitenpyram exposure during pregnancy

Cited by 24 publications

References 45 publications

Microbiome Analysis Reveals the Dynamic Alternations in Gut Microbiota of Diarrheal Giraffa camelopardalis

Microbiome Analysis Reveals the Dynamic Alternations in Gut Microbiota of Diarrheal Giraffa camelopardalis

Toxicology and Microbiota: How Do Pesticides Influence Gut Microbiota? A Review

Pregnancy exposure of titanium dioxide nanoparticles causes intestinal dysbiosis and neurobehavioral impairments that are not significant postnatally but emerge in adulthood of offspring

Contact Info

Product

Resources

About