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Cited by 41 publications
(26 citation statements)
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“…Some studies suggested that hypertension is already occurred in newly diagnosed T2DM (59). The development of hypertension in diabetics can partly be explained by the presence of increased inflammation and vascular dysfunction associated with the imbalance between angiotensin II-angiotensin1-7 (60). Hence hypertension is one of the extremely important factors that influence the onset of nephropathy in T1DM or T2DM patients.…”
Section: Discussionmentioning
confidence: 99%
“…Some studies suggested that hypertension is already occurred in newly diagnosed T2DM (59). The development of hypertension in diabetics can partly be explained by the presence of increased inflammation and vascular dysfunction associated with the imbalance between angiotensin II-angiotensin1-7 (60). Hence hypertension is one of the extremely important factors that influence the onset of nephropathy in T1DM or T2DM patients.…”
Section: Discussionmentioning
confidence: 99%
“…L’ACE2, à une moindre échelle, clive aussi l’angiotensine I en angiotensine (1-9), qui est ensuite convertie en angiotensine (1-7) par l’ACE1. L’angiotensine (1-7) s’oppose à l’action de l’angiotensine II — via la liaison au récepteur Mas et au récepteur de l’angiotensine II de type 2 (AT2) — en abaissant la pression artérielle via une légère vasodilatation médiée par le NO et les prostacyclines, en favorisant l’excrétion rénale de sodium et d’eau, et en exerçant un effet anti-inflammatoire [4] .…”
Section: Physiopathologieunclassified
“…T2DM leads to the impairment of both health and quality of life, causing chronic heart disease, cardiovascular disease, microvascular complications, and neurological abnormalities [2,3]. Addtionally, T2DM is associated with severe arteriosclerosis, hypertension, hyperlipidemia, and inflammation, all of which further contribute to the development of cardiovascular disease [4]. Cardiovascular disease, which is the primary complication in patients with diabetes mellitus, progresses to heart failure in more than 70% of cases, thereby drastically increasing the mortality and morbidity rate [5].…”
Section: Introductionmentioning
confidence: 99%