Imatinib inhibits in vitro proliferation of cells derived from a pleural solitary fibrous tumor expressing platelet-derived growth factor receptor-beta

Prunotto, Marco; Bosco, Martino; Lilleri, Daniele; Macrì, Luigia; Bonello, Laurent; Schirosi, Laura; Rossi, Giulio; Filosso, Pier Luigi; Mussa, Baudolino; Sapino, Anna

doi:10.1016/j.lungcan.2008.10.013

Cited by 19 publications

(13 citation statements)

References 12 publications

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“…Other alternative treatment modalities have also been attempted. The novel targeted drug imatinib mesylate seems to exert some activity on SFT expressing the wild-type platelet-derived growth factor receptor-b: its in vitro [17] and in vivo [18] inhibitory activity in chemoand radioresistant malignant SFT has recently been demonstrated [11]. Consensus has not been achieved yet concerning radiotherapy and chemotherapy against SFT, but our present report is one supportive of the effectiveness of preoperative radiotherapy for the safe gross total removal of a large pelvic malignant SFT.…”

Section: Case Reportmentioning

confidence: 51%

A hypervascular malignant solitary fibrous tumor in the mesentery of the rectum with good response to preoperative radiation therapy

Nishikawa

Takei²,

Teshima³

et al. 2012

Int Canc Conf J

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Solitary fibrous tumor (SFT) is an uncommon neoplasm located in the pelvis. Here, we report a case of hypervascular malignant SFT in the mesentery of the rectum that showed a significant response to preoperative radiotherapy. A 36-year-old man presented to our department with constipation and dysuria. Abdominal computed tomography confirmed a large round neoformation (155 mm in the longest diameter) with an evident contrastenhanced periphery and a central necrotic area in the pelvis. Considering the results of the examinations, a pelvic neoplasm was strongly suspected. Due to the difficulty of safe gross total removal, a diagnostic laparotomy was indicated. Histologically, hypercellularity with spindleshaped cells and high mitotic activity was observed. Immunohistochemically, the tumor was positive for CD34, CD99, and bcl-2. The diagnosis of hypervascular malignant SFT was made. After the appropriate information had been given, the patient chose the use of preoperative radiotherapy. After local irradiation, the tumor size regressed to 105 mm in the longest diameter. Laparotomy revealed a tumor originating from the mesentery of the rectum, and the tumor was successfully excised. This case strongly suggested the potential applicability of preoperative radiotherapy for the safe gross total removal of a large pelvic SFT.

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Section: Case Reportmentioning

confidence: 51%

A hypervascular malignant solitary fibrous tumor in the mesentery of the rectum with good response to preoperative radiation therapy

Nishikawa

Takei²,

Teshima³

et al. 2012

Int Canc Conf J

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“…Radiation therapy is of some benefit, when applicable, given in combination with chemotherapy (13). The novel targeted drug imatinib mesilate, which exerts some activity on SFTs expressing the wild-type PDGFR-β, has recently been reported (14,15).…”

Section: Discussionmentioning

confidence: 99%

Two malignant solitary fibrous tumors in one kidney: Case report and review of the literature

Zhao

Han

2012

Oncology Letters

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Abstract. Malignant solitary fibrous tumors of the kidney are very rare. Two tumors in one kidney is particularly rare and has not been previously reported. Due to the non-specific clinical symptoms, it is difficult but also very significant to give a definite diagnosis. Here, we report a case of two renal masses in one kidney. A 56-year-old man was admitted to our hospital complaining of shortness of breath, weakness, hyperhidrosis and intermittent hypoglycemia of 1-year duration without gross hematuria or lumbago. Imaging studies revealed two masses manifesting as inhomogeneous, with soft-tissue density and having no clear boundaries with the kidney. The patient was initially diagnosed with spaceoccupying lesions of the left kidney (with suspicions of renal cell carcinoma) and left radical nephrectomy was performed. Histologically, the tumors consisted of ovoid or spindle cells, and a hemangiopericytoma-like pattern and cellular atypia was observed in certain areas. Mitotic figures were more than 4 per 10 high-power fields. Immunohistochemically the tumor cells were positive for CD34, CD99 and vimentin. Accordingly, a diagnosis of malignant solitary fibrous tumor of the left kidney (low-grade malignance) was established. Postoperative follow-up of 10 months did not find tumor recurrence or metastasis and hypoglycemia was resolved with the removal of the tumors.

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“…Chemotherapy alone or combined with radiotherapy is reserved for multi-metastatic disease or for ones that cannot be surgically removed. A new therapeutic possibility with imatinib mesylate has recently been reported for metastatic intrapleural SFT characterized by wild type PDGFR-β expression 14,15…”

Section: Discussionmentioning

confidence: 99%

Renal malignant solitary fibrous tumor with single lymph node involvement: report of unusual metastasis and review of the literature

Mearini

Cochetti

Barillaro

et al. 2014

OTT

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Solitary fibrous tumors are rare mesenchymal spindle cell neoplasms that are usually found in the pleura. The kidneys are an uncommon site and only few cases of renal solitary fibrous tumor exhibit malignant behavior metastasizing to the liver, lung, and bone through the hematogenous pathway.PurposeTo describe the first case of lymph node metastasis from renal solitary fibrous tumor in order to increase the knowledge about the malignant behavior of these tumors.Patients and methodsA 19-year-old female patient had intermittent hematuria for several months without flank pain or other symptoms. A chest and abdomen CT scan was performed and showed a multi-lobed bulky solid mass of 170 × 98 × 120 mm in the left kidney. One day before the surgery, the left renal artery was catheterized and the kidney embolization was performed using a Haemostatic Absorbable Gelatin Sponge and polyvinyl alcohol. We then performed a radical nephrectomy with hilar, para-aortic, and inter-aortocaval lymphadenectomy.ResultsEstimated intraoperative blood loss was 200 mL and the operative time was 100 minutes. No postoperative complications occurred. The hospital stay was 7 days long. The histological examination was malignant solitary fibrous tumor of the kidney. Cancerous tissue showed cellular atypia, with an increased mitotic index (up to 7 × 10 hpf). Immunohistochemical analysis showed positive results for CD34, BCL2, partial expression of HBME1, and occasionally of synaptophysin. Histological evaluation confirmed the presence of metastasis in one hilar node. The patient did not receive any other therapy. At 30-month follow-up, the patient was in good health and no local recurrence or metastases had occurred.ConclusionThis is the first case of lymph node metastasis from a renal solitary fibrous tumor showing unusual malignant behavior; this finding adds new information about the biology and progression of these tumors, which remain unclear.

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Imatinib inhibits in vitro proliferation of cells derived from a pleural solitary fibrous tumor expressing platelet-derived growth factor receptor-beta

Cited by 19 publications

References 12 publications

A hypervascular malignant solitary fibrous tumor in the mesentery of the rectum with good response to preoperative radiation therapy

A hypervascular malignant solitary fibrous tumor in the mesentery of the rectum with good response to preoperative radiation therapy

Two malignant solitary fibrous tumors in one kidney: Case report and review of the literature

Renal malignant solitary fibrous tumor with single lymph node involvement: report of unusual metastasis and review of the literature

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