Imaging side effects and complications of chemotherapy and radiation therapy: a pictorial review from head to toe

Albano, Domenico; Benenati, Massimo; Bruno, Antonio; Bruno, Federico; Calandri, Marco; Cozzi, Diletta; Robertis, Riccardo De; Gentili, Francesco; Grazzini, Irene; Micci, Giuseppe; Palmisano, Anna; Pessina, Carlotta; Scalise, Paola; Vernuccio, Federica; Barile, Antonio; Miele, Vittorio; Grassi, Roberto; Messina, Carmelo

doi:10.1186/s13244-021-01017-2

Cited by 56 publications

(39 citation statements)

References 111 publications

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“…This finding goes in line with Albano, et al, (2021) who studied "Imaging side effects and complications of chemotherapy and radiation therapy" supports the opinion by stating that radiation therapy though administered locally, can produce systemic side effects such as fatigue, anorexia, nausea, vomiting, alteration in the taste, sleep disturbance, headache, anemia, dry skin, constipation etc. Also, this is consistent with Rajesh,, et al, (2022) who studied "An observational study to monitor and report radiation-related adverse events by a clinical pharmacist to achieve a better therapeutic outcome and suggest preventive measures in a tertiary care teaching hospital" reported that radiotherapy-induced fatigue was a common early and chronic side effect of irradiation and it was reported more in patients with head-and-neck cancers due to activation of Pro-inflammatory cytokines.…”

Section: Discussionsupporting

confidence: 80%

“…Part I: Socio-demographic characteristics of the studied patients. Table (1) shows that the highest percent of studied patients age (33.5%) was 60 years or more and (31.5%) falls between (50-<60), more than half of them were female patients (58,3%), Regarding educational level about (31.7%) of studied patients read and write, (38.3%) of studied patients are not working and (35%) are working, (66.7%) of studied patients have low income.…”

Section: Resultsmentioning

confidence: 99%

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needs of patients receiving brain radiotherapy at Fayoum oncology center

Ali¹,

Alwani²,

Shaban³

et al. 2022

ijhs

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Background: Brain radiotherapy is an indispensable mainstay treatment for the majority of brain tumors. It has an important role in the treatment of brain tumors either with curative intent or for palliation. Although radiotherapy is well tolerated by most patients, some experience radiation-induced side effects. Aim of the study: To assess the needs of patients receiving brain radiotherapy at fayoum oncology center. Design: Descriptive exploratory research design was used to conduct this study. Setting: The study was conducted in the radiotherapy unit at Fayoum Oncology Center at fayoum governorate. Subjects: A purposive sample of 60 adult patients from both gender receiving brain radiotherapy. Tools: A structured interviewing questionnaire included socio-demographic data, medical history, surgical history and patients' health needs assessment questionnaire. Results: the highest unfulfilled health needs of patients treated with brain radiotherapy were discomfort, activities of daily living, anxiety and depression. There is statistically significant correlation between physical health needs, psychological and social health needs. Additionally, there is statistically significant correlation between physical discomfort and anxiety and between physical discomfort and depression Conclusion: The study concluded that the patients suffered from unfulfilled health needs physical, social and psychological.

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Section: Discussionsupporting

confidence: 80%

Section: Resultsmentioning

confidence: 99%

needs of patients receiving brain radiotherapy at Fayoum oncology center

Ali¹,

Alwani²,

Shaban³

et al. 2022

ijhs

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show abstract

“…Functional MR data provide quantifiable information about underlying tissue characteristics [ 44 , 64 ]. The combination of objective biomarkers with morphologic data makes functional MRI a powerful tool that provides comprehensive information about lesion heterogeneity and therapy-induced changes in heterogeneity [ 28 , 85 , 86 ]. Functional MRI has additional potential in the early stages of treatment efficacy evaluation and should be useful in drug development [ 86 ].…”

Section: Functional Magnetic Resonance Imagingmentioning

confidence: 99%

Advanced Magnetic Resonance Imaging (MRI) Techniques: Technical Principles and Applications in Nanomedicine

Bruno

Granata

Bellisari

et al. 2022

Cancers

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In the last decades, nanotechnology has been used in a wide range of biomedical applications, both diagnostic and therapeutic. In this scenario, imaging techniques represent a fundamental tool to obtain information about the properties of nanoconstructs and their interactions with the biological environment in preclinical and clinical settings. This paper reviews the state of the art of the application of magnetic resonance imaging in the field of nanomedicine, as well as the use of nanoparticles as diagnostic and therapeutic tools, especially in cancer, including the characteristics that hinder the use of nanoparticles in clinical practice.

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“…Treatment for lung cancer differs according to subtype and stage ( Hayashi et al, 2011 ). Chemotherapy and radiotherapy have side effects ( Albano et al, 2021 ), and even targeted immunotherapeutic have a considerable symptom burden ( Lim et al, 2020 ). Therefore, research on new drugs and combined therapies is needed.…”

Section: Introductionmentioning

confidence: 99%

Network Pharmacology-Based Prediction and Verification of Ginsenoside Rh2-Induced Apoptosis of A549 Cells via the PI3K/Akt Pathway

et al. 2022

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Ginsenoside Rh2 (G-Rh2), a rare protopanaxadiol (PPD)-type triterpene saponin, from Panax ginseng has anti-proliferation, anti-invasion, and anti-metastatic activity. However, the mechanisms by which G-Rh2 induces apoptosis of lung cancer cells are unclear. In the present work, a G-Rh2 target-lung cancer network was constructed and analyzed by the network pharmacology approach. A total of 91 compound-targets of G-Rh2 was obtained based on the compound-target network analysis, and 217 targets were identified for G-Rh2 against lung cancer by PPI network analysis. The 217 targets were significantly enriched in 103 GO terms with FDR <0.05 as threshold in the GO enrichment analysis. In KEGG pathway enrichment analysis, all the candidate targets were significantly enriched in 143 pathways, among of which PI3K-Akt signaling pathway was identified as one of the top enriched pathway. Besides, G-Rh2 induced apoptosis in human lung epithelial (A549) cells was verified in this work. G-Rh2 significantly inhibited the proliferation of A549 cells in a dose-dependent manner, and the apoptosis rate significantly increased from 4.4% to 78.7% using flow cytometry. Western blot analysis revealed that the phosphorylation levels of p85, PDK1, Akt and IκBα were significantly suppressed by G-Rh2. All the experimental findings were consistent with the network pharmacology results. Research findings in this work will provide potential therapeutic value for further mechanism investigations.

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Imaging side effects and complications of chemotherapy and radiation therapy: a pictorial review from head to toe

Cited by 56 publications

References 111 publications

needs of patients receiving brain radiotherapy at Fayoum oncology center

needs of patients receiving brain radiotherapy at Fayoum oncology center

Advanced Magnetic Resonance Imaging (MRI) Techniques: Technical Principles and Applications in Nanomedicine

Network Pharmacology-Based Prediction and Verification of Ginsenoside Rh2-Induced Apoptosis of A549 Cells via the PI3K/Akt Pathway

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