Imaging of pulmonary perfusion using subtraction CT angiography is feasible in clinical practice

Grob, Dagmar; Oostveen, Luuk J.; Prokop, Mathias; Schaefer-Prokop, Cornelia; Sechopoulos, Ioannis; Brink, Monique

doi:10.1007/s00330-018-5740-4

Cited by 26 publications

(24 citation statements)

References 31 publications

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“…We note that in case of in-vivo experiments, binary tomography is only applicable when an imaging protocol ensures that only the organ of interest is X-ray projected. This can be achieved, e.g., by Substraction Computed Tomography (SCT) [ 9 , 17 , 37 ].…”

Section: Proposed Methodsmentioning

confidence: 99%

Limited-view binary tomography reconstruction assisted by shape centroid

Lukić

Balázs

2021

Vis Comput

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Section: Proposed Methodsmentioning

confidence: 99%

Limited-view binary tomography reconstruction assisted by shape centroid

Lukić

Balázs

2021

Vis Comput

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“…Lung perfusion CT is performed using either dynamic perfusion or dual scan perfusion techniques that include lung subtraction 2 , 3 and dual energy (DE) 4 – 6 . In dual scan perfusion, quantitative color-coded maps are generated that correspond to the distribution of iodine.…”

Section: Introductionmentioning

confidence: 99%

Quantitative assessment of pulmonary artery occlusion using lung dynamic perfusion CT

Jiménez-Juan

Mehrez

Dey

et al. 2021

Sci Rep

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Quantitative measurement of lung perfusion is a promising tool to evaluate lung pathophysiology as well as to assess disease severity and monitor treatment. However, this novel technique has not been adopted clinically due to various technical and physiological challenges; and it is still in the early developmental phase where the correlation between lung pathophysiology and perfusion maps is being explored. The purpose of this research work is to quantify the impact of pulmonary artery occlusion on lung perfusion indices using lung dynamic perfusion CT (DPCT). We performed Lung DPCT in ten anesthetized, mechanically ventilated juvenile pigs (18.6–20.2 kg) with a range of reversible pulmonary artery occlusions (0%, 40–59%, 60–79%, 80–99%, and 100%) created with a balloon catheter. For each arterial occlusion, DPCT data was analyzed using first-pass kinetics to derive blood flow (BF), blood volume (BV) and mean transit time (MTT) perfusion maps. Two radiologists qualitatively assessed perfusion maps for the presence or absence of perfusion defects. Perfusion maps were also analyzed quantitatively using a linear segmented mixed model to determine the thresholds of arterial occlusion associated with perfusion derangement. Inter-observer agreement was assessed using Kappa statistics. Correlation between arterial occlusion and perfusion indices was evaluated using the Spearman-rank correlation coefficient. Our results determined that perfusion defects were detected qualitatively in BF, BV and MTT perfusion maps for occlusions larger than 55%, 80% and 55% respectively. Inter-observer agreement was very good with Kappa scores > 0.92. Quantitative analysis of the perfusion maps determined the arterial occlusion threshold for perfusion defects was 50%, 76% and 44% for BF, BV and MTT respectively. Spearman-rank correlation coefficients between arterial occlusion and normalized perfusion values were strong (− 0.92, − 0.72, and 0.78 for BF, BV and MTT, respectively) and were statically significant (p < 0.01). These findings demonstrate that lung DPCT enables quantification and stratification of pulmonary artery occlusion into three categories: mild, moderate and severe. Severe (occlusion ≥ 80%) alters all perfusion indices; mild (occlusion < 55%) has no detectable effect. Moderate (occlusion 55–80%) impacts BF and MTT but BV is preserved.

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“…Several nasal spray deposition assessment methods, both in vivo and in vitro , have been reported [1–5], yet each method bears substantial limitations such as lack of simplicity or low clinical suitability. An imaging approach such as computed tomography (CT) with its high temporal and spatial resolution and possibly low radiation dose may represent a valuable approach as it enables a fast acquisition of images and is readily available in various clinical settings [6–11].…”

Section: Introductionmentioning

confidence: 99%

In vitro qualitative and quantitative CT assessment of iodinated aerosol nasal deposition using a 3D-printed nasal replica

Sartoretti¹,

Mannil

Biendl³

et al. 2019

Eur Radiol Exp

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Computed tomography can provide high-resolution details on nasal anatomy being potentially useful for the assessment of nasal spray deposition. The purpose of this technical note was to present a method based on CT imaging to assess qualitatively and quantitatively the in vitro spray deposition patterns within the sinonasal cavities of a nasal replica obtained by three-dimensional (3D) printing, using iodinated contrast agent labelled solutions with high spatial and temporal resolution. Using a third generation dual-source CT scanner in single energy mode, scans of a nasal replica were acquired following application of iodinated contrast agent labelled aerosols with an iodine concentration of 92.5 mgl/mL. Two software programmes were then utilised (Osirix MD v.9.0, Pixmeo, Geneva, Switzerland; 3mensio, Pie Medical Imaging, Bilthoven, Netherlands) to generate three-dimensional reconstructions of the scans, thus enabling the rapid detection and visualisation of administered single droplets and their voxel-by-voxel localisation. Using this approach, we achieved recovery rates between 84–98% and 89–109% (depending on the software programme) of the total applied aerosol volume.

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Imaging of pulmonary perfusion using subtraction CT angiography is feasible in clinical practice

Cited by 26 publications

References 31 publications

Limited-view binary tomography reconstruction assisted by shape centroid

Limited-view binary tomography reconstruction assisted by shape centroid

Quantitative assessment of pulmonary artery occlusion using lung dynamic perfusion CT

In vitro qualitative and quantitative CT assessment of iodinated aerosol nasal deposition using a 3D-printed nasal replica

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