Abstract:To visualize the entire process of encephalitogenic T cell infiltration into the target organ, we performed intravital imaging by using two-photon microscopy in experimental autoimmune encephalomyelitis, the animal model of multiple sclerosis. Intravital imaging documented that T cells first appear in the leptomeningeal blood vessels where they crawl in an integrin-dependent manner and scan the intraluminal surface for extravasation sites. After diapedesis, the T cells continue to crawl on the abluminal surfac… Show more
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