Imaging in COPD

A reference dataset for deformable image registration spatial accuracy evaluation using the COPDgene study archive

“…The focus of the present study was to expand the utility of our current reference database by incorporating an additional and independent imaging cohort. Three major multi-site NHLBIsponsored studies (Lung Tissue Research Consortium, COPDgene, and Sub-populations and Intermediate Outcome Measures in COPD Study) collect and archive inhale and exhale BH-CT image pairs from thousands of research study subjects along with clinical, tissue, and genomic data (Regan et al 2010, Beek and Hoffman 2009, Holmes et al 2006 Figure 8 provides a graphical summary of the reference library data that is currently available online. In the figure, cases 1-10 represent clinically acquired treatment planning 4D CT, while cases 11-20 represent those obtained from the COPDgene archive and described in this work.…”

A reference dataset for deformable image registration spatial accuracy evaluation using the COPDgene study archive

“…The focus of the present study was to expand the utility of our current reference database by incorporating an additional and independent imaging cohort. Three major multi-site NHLBIsponsored studies (Lung Tissue Research Consortium, COPDgene, and Sub-populations and Intermediate Outcome Measures in COPD Study) collect and archive inhale and exhale BH-CT image pairs from thousands of research study subjects along with clinical, tissue, and genomic data (Regan et al 2010, Beek and Hoffman 2009, Holmes et al 2006 Figure 8 provides a graphical summary of the reference library data that is currently available online. In the figure, cases 1-10 represent clinically acquired treatment planning 4D CT, while cases 11-20 represent those obtained from the COPDgene archive and described in this work.…”

Techniques of assessing small airways dysfunction

“…Diffusion imaging visualises the movement of 3 He in the peripheral airspaces, bound by alveolar and airways walls. This is calculated as the apparent diffusion co-efficient (ADC) and gives insight into the microstructure of the distal airspaces ( 158 ). ADC is increased in healthy smokers with normal lung function and correlates with smoking history ( 159 , 160 ), suggesting it is a sensitive marker of early damage.…”

CT assessment of lobar heterogenity and fissure integrity in pulmonary emphysema for bronchoscopic lung volume reduction with valve

“…Today, advances in bronchoscopic techniques such as bronchial valves have been increasing the value of CT quantitative analysis for COPD patients. Apollo software (VIDA Diagnostics, Inc.) is a quantitative lung imaging software which uses algorithmic workfl ow and automation features applicable to high-volume, repeatable parenchymal, airway, and fi ssure integrity analysis [8][9][10] .…”

A reference dataset for deformable image registration spatial accuracy evaluation using the COPDgene study archive

“…The focus of the present study was to expand the utility of our current reference database by incorporating an additional and independent imaging cohort. Three major multi-site NHLBIsponsored studies (Lung Tissue Research Consortium, COPDgene, and Sub-populations and Intermediate Outcome Measures in COPD Study) collect and archive inhale and exhale BH-CT image pairs from thousands of research study subjects along with clinical, tissue, and genomic data (Regan et al 2010, Beek and Hoffman 2009, Holmes et al 2006 Figure 8 provides a graphical summary of the reference library data that is currently available online. In the figure, cases 1-10 represent clinically acquired treatment planning 4D CT, while cases 11-20 represent those obtained from the COPDgene archive and described in this work.…”

Techniques of assessing small airways dysfunction

“…Diffusion imaging visualises the movement of 3 He in the peripheral airspaces, bound by alveolar and airways walls. This is calculated as the apparent diffusion co-efficient (ADC) and gives insight into the microstructure of the distal airspaces ( 158 ). ADC is increased in healthy smokers with normal lung function and correlates with smoking history ( 159 , 160 ), suggesting it is a sensitive marker of early damage.…”

CT assessment of lobar heterogenity and fissure integrity in pulmonary emphysema for bronchoscopic lung volume reduction with valve

“…Today, advances in bronchoscopic techniques such as bronchial valves have been increasing the value of CT quantitative analysis for COPD patients. Apollo software (VIDA Diagnostics, Inc.) is a quantitative lung imaging software which uses algorithmic workfl ow and automation features applicable to high-volume, repeatable parenchymal, airway, and fi ssure integrity analysis [8][9][10] .…”

A reference dataset for deformable image registration spatial accuracy evaluation using the COPDgene study archive

“…The focus of the present study was to expand the utility of our current reference database by incorporating an additional and independent imaging cohort. Three major multi-site NHLBIsponsored studies (Lung Tissue Research Consortium, COPDgene, and Sub-populations and Intermediate Outcome Measures in COPD Study) collect and archive inhale and exhale BH-CT image pairs from thousands of research study subjects along with clinical, tissue, and genomic data (Regan et al 2010, Beek and Hoffman 2009, Holmes et al 2006 Figure 8 provides a graphical summary of the reference library data that is currently available online. In the figure, cases 1-10 represent clinically acquired treatment planning 4D CT, while cases 11-20 represent those obtained from the COPDgene archive and described in this work.…”

Techniques of assessing small airways dysfunction

“…Diffusion imaging visualises the movement of 3 He in the peripheral airspaces, bound by alveolar and airways walls. This is calculated as the apparent diffusion co-efficient (ADC) and gives insight into the microstructure of the distal airspaces ( 158 ). ADC is increased in healthy smokers with normal lung function and correlates with smoking history ( 159 , 160 ), suggesting it is a sensitive marker of early damage.…”

CT assessment of lobar heterogenity and fissure integrity in pulmonary emphysema for bronchoscopic lung volume reduction with valve

“…Today, advances in bronchoscopic techniques such as bronchial valves have been increasing the value of CT quantitative analysis for COPD patients. Apollo software (VIDA Diagnostics, Inc.) is a quantitative lung imaging software which uses algorithmic workfl ow and automation features applicable to high-volume, repeatable parenchymal, airway, and fi ssure integrity analysis [8][9][10] .…”