Imaging findings of primary malignant gastrointestinal stromal tumor of the liver

Kim, Hyun Ok; Kim, Ji Eun; Bae, Kyung‐Yeol; Choi, Bong Hoi; Jeong, Chi Young; Lee, Jong Sil

doi:10.1007/s11604-014-0307-z

Cited by 19 publications

(15 citation statements)

References 10 publications

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“…iii) Finally, there was a possibility that a mural GIST experienced extensive extramural growth, resulting in an eventual loss of connection with the gut wall ( 9 ). The lost tumor cells may have first successfully seeded in the pancreas, before later seeding in the liver, as primary EGIST of liver has been previously reported ( 29 – 31 ).…”

Section: Discussionmentioning

confidence: 70%

“…Primary pancreatic EGISTs are rare in the clinic and in the literature, with only ~20 cases reported to date ( 11 – 28 ). Similarly, hepatic EGIST is also rare ( 29 – 31 ). The occurrence of a primary pancreatic EGIST accompanied by a primary hepatic EGIST in the same patient is, therefore, considered to be an extremely rare event.…”

Section: Introductionmentioning

confidence: 99%

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Coexisting and possible primary extra-gastrointestinal stromal tumors of the pancreas and liver: A single case report

et al. 2016

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Gastrointestinal stromal tumors (GIST) are mesenchymal neoplasms of the gastrointestinal tract (GI) that are defined, in part, by the expression of CD117, a c-Kit proto-oncogene protein. GISTs emerge outside of the GI at a very low frequency, typically in a single organ or location. GISTs that occasionally emerge outside of the GI are classified as extra-gastrointestinal stromal tumors (EGIST). The present study reports an extremely rare case of EGIST detected in the pancreas and the liver. The pancreatic and liver tumors were 4.5×2.5 cm and 2.0×1.5 cm in size, respectively. Both tumors consisted of CD117-positive spindle cells with a similar mitotic rate of 1–2 per 50 high power fields. The pancreatic and the hepatic EGISTs were at a low risk of malignancy, and both tumors were proposed to be primary stromal tumors. To the best of our knowledge, this is the first report of likely primary EGIST identified in the pancreas and liver of the same patient.

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Section: Discussionmentioning

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Coexisting and possible primary extra-gastrointestinal stromal tumors of the pancreas and liver: A single case report

et al. 2016

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“…A PubMed search was performed using the keywords: “gastrointestinal stromal tumors,” “extra-gastrointestinal stromal tumors,” “primary hepatic tumor,” and limited to reports on human adults and English and Japanese-language publications, including case reports. Primary GIST of the liver is a type of EGIST; only eight previous case studies involving this tumor have been reported in the literature until 2015 [18–25]. The clinicopathological features and treatment outcomes of the reported primary hepatic GISTs, including the present case, are detailed in Table 1.…”

Section: Discussionmentioning

confidence: 92%

Primary gastrointestinal stromal tumor of the liver: a case report and review of the literature

et al. 2016

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BackgroundRecently, gastrointestinal stromal tumors that have developed outside of the digestive tract have been reported. These tumors are collectively termed extra-gastrointestinal stromal tumors. Extra-gastrointestinal stromal tumors can also develop in the liver. Only eight case reports involving primary GIST of the liver have been published. We report a case and review the literature regarding this disease.Case presentationA 70-year-old woman with a past history of gastric cancer visited our hospital for regular inspection. With extensive radiological imaging, a computed tomography scan revealed a mass with a size of 6.8 cm in the lateral segment of the liver. 18F-Fluoro-2-deoxyglucose positron emission tomography revealed no other malignancies except for the liver tumor. Because the lesion was suspected of being a primary malignant hepatic tumor, lateral segmentectomy was performed. The immunohistochemical analysis supported the diagnosis of gastrointestinal stromal tumors in the liver. The patient has had no evidence of recurrence during the 10-month follow-up period; imatinib chemotherapy was not administered.ConclusionsPrimary hepatic gastrointestinal stromal tumors had no characteristics that distinguished them from ordinary tumors in imaging examinations. Primary gastrointestinal stromal tumors might have developed from interstitial Cajal-like cells.

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“…However, Hyum reported a case of primary hepatic GISTs showed the same degree of enhancement compared to live parenchyma in the arterial phase and persistent enhancement in the portal venous and delayed phase. 32 And he deemed GISTs were consisted of a wide range of pathologic spectrum, contributing to the discrepancy of different enhancement degree and pattern.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological Features and Clinical Outcomes of Primary Hepatic Gastrointestinal Stromal Tumors: Evaluation of a Pooled Case Series

Zheng

2020

Preprint

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Background: Due to the extremely rare incidence, data of clinicopathological features and prognosis of primary hepatic gastrointestinal stromal tumors (GISTs) is limited. Methods: 36 cases of hepatic GISTs were from the literature, PUBMED, EMBASE, China National Knowledge Infrastructure and WANFANG DATA, and 1 case came from our center. Clinicopathological features and outcomes were analyzed between 37 hepatic GISTs and 254 gastric GISTs from our center. Results: A majority of hepatic GISTs exceeded 5 cm (83.7%), displayed mixed density (69.4%) and spindle morphology (74.2%) and were classified as high risk (91.4%). Larger tumors of hepatic GISTs were likely to display mixed lesion and tumors with mixed lesion were prone to be classified as high risk. In comparisons to gastric GISTs, hepatic GISTs differed from gastric GISTs in tumor size, main symptoms, histologic type, mitotic index, CD34 expression, NIH risk classification. In patients with hepatic GISTs, 5-year DFS and DSS rates were 19.4% and 53.7%, which were worse than that of gastric GISTs (P＜ 0.001), especially for those with tumor size exceeding 5 cm or mitotic indices exceeding 5/50 HPF (P < 0.001). Multivariable analysis showed location and NIH risk classification were independent prognostic factors for DFS in patients with GISTs, and size and location were significantly associated with DSS. Conclusions: Hepatic GISTs distinguished from gastric GISTs in respect to clinicopathological features and outcomes. Mitotic index exceeding 5/50 HPF or tumor size exceeding 5 cm may be important factor to distinguish hepatic GISTs from gastric GISTs in DFS and DSS.

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Imaging findings of primary malignant gastrointestinal stromal tumor of the liver

Cited by 19 publications

References 10 publications

Coexisting and possible primary extra-gastrointestinal stromal tumors of the pancreas and liver: A single case report

Coexisting and possible primary extra-gastrointestinal stromal tumors of the pancreas and liver: A single case report

Primary gastrointestinal stromal tumor of the liver: a case report and review of the literature

Clinicopathological Features and Clinical Outcomes of Primary Hepatic Gastrointestinal Stromal Tumors: Evaluation of a Pooled Case Series

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