Imaging features of diffuse hemispheric glioma, H3 G34-mutant: Report of 4 cases

Kalelioğlu, Tuba; Emerson, Dow; Luk, Allen; Lopes, Beatriz; Patel, Sohil H.

doi:10.1016/j.neurad.2022.12.001

Cited by 3 publications

(5 citation statements)

References 9 publications

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“…Lactate and/or lipid peaks were also frequently observed. Perfusion studies tended to demonstrate hyperperfusion [73,120,121,125,128], although hypoperfusion was occasionally seen. High uptake on 18F-fluoroethyl-L-tyrosine positron emission tomography (18F-FET-PET) was observed [126].…”

Section: Radiologic Findings Common To H33-g34r/v Mutant Gliomasmentioning

confidence: 99%

“…The findings on advanced imaging modalities were also relatively nonspecific with the reversal of Hunter's angle on MRI spectroscopy being a common finding [73,120,121,128]. Lactate and/or lipid peaks were also frequently observed.…”

Section: Radiologic Findings Common To H33-g34r/v Mutant Gliomasmentioning

confidence: 99%

“…A number of studies reported on clinical presentation and/or survival [66][67][68][69][70][71][72][73][74][75][108][109][110][111][112][113][114][115][116][117][118][119][120][121][122][123]. Survival is discussed below with treatment regimens in a separate section.…”

Section: Baseline Information and Clinical Presentation Of Patients W...mentioning

confidence: 99%

“…On magnetic resonance imaging (MRI), H3.3-G34R/V mutant gliomas tended to be T1 hypo-to isointense and T2 hyperintense, display mild edema relative to the size of the mass, exhibit at least some degree of diffusion restriction, have ill-defined margins, and demonstrate an infiltrative growth pattern [73][74][75]120,121,[124][125][126][127][128][129]. All were supratentorial with a variable contrast enhancement, although a significant proportion of tumors demonstrated minimal contrast enhancement or none.…”

Section: Radiologic Findings Common To H33-g34r/v Mutant Gliomasmentioning

confidence: 99%

“…Treatments often included biopsy or resection followed by chemotherapy and/or radiation therapy [3,51,72,120,121,123,124,134], with a few studies having employed craniospinal radiation [3,72,114]. Hemispheric tumors are considered more resectable due to an easier accessibility and remoteness from deeper structures essential for basic survival functions, with one meta-analysis detailing adult patients with high-grade gliomas of all types undergoing gross total resection in nearly 50% of hemispheric tumors but only approximately 20% of midline gliomas [135].…”

Section: Treatment Outcomes and Factors Associated With Improved Prog...mentioning

confidence: 99%

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H3G34-Mutant Gliomas—A Review of Molecular Pathogenesis and Therapeutic Options

et al. 2023

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The 2021 World Health Organization Classification of Tumors of the Central Nervous System reflected advances in understanding of the roles of oncohistones in gliomagenesis with the introduction of the H3.3-G34R/V mutant glioma to the already recognized H3-K27M altered glioma, which represent the diagnoses of pediatric-type diffuse hemispheric glioma and diffuse midline glioma, respectively. Despite advances in research regarding these disease entities, the prognosis remains poor. While many studies and clinical trials focus on H3-K27M-altered-glioma patients, those with H3.3-G34R/V mutant gliomas represent a particularly understudied population. Thus, we sought to review the current knowledge regarding the molecular mechanisms underpinning the gliomagenesis of H3.3-G34R/V mutant gliomas and the diagnosis, treatment, long-term outcomes, and possible future therapeutics.

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Section: Radiologic Findings Common To H33-g34r/v Mutant Gliomasmentioning

confidence: 99%

Section: Radiologic Findings Common To H33-g34r/v Mutant Gliomasmentioning

confidence: 99%

Section: Baseline Information and Clinical Presentation Of Patients W...mentioning

confidence: 99%

Section: Radiologic Findings Common To H33-g34r/v Mutant Gliomasmentioning

confidence: 99%

Section: Treatment Outcomes and Factors Associated With Improved Prog...mentioning

confidence: 99%

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H3G34-Mutant Gliomas—A Review of Molecular Pathogenesis and Therapeutic Options

et al. 2023

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Midline invasion predicts poor prognosis in diffuse hemispheric glioma, H3 G34-mutant: an individual participant data review

Kegoya,

Otani,

Inoue

et al. 2024

J Neurooncol

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Introduction Diffuse hemispheric glioma, H3 G34-mutant (DHGs), is a newly categorized tumor in pediatric-type diffuse high-grade gliomas, World Health Organization grade 4, with a poor prognosis. Although prognostic factors associated with genetic abnormalities have been reported, few reports have examined the clinical presentation of DHGs, especially from the viewpoint of imaging findings. In this study, we investigated the relationship between clinical factors, including imaging findings, and prognosis in patients with DHGs. Methods We searched Medline through the PubMed database using two search terms: “G34” and “glioma”, between 1 April 2012 and 1 July 2023. We retrieved articles that described imaging findings and overall survival (OS), and added one DHG case from our institution. We defined midline invasion (MI) as invasion to the contralateral cerebrum, brainstem, corpus callosum, thalamus, and basal ganglia on magnetic resonance imaging. The primary outcome was 12-month survival, estimated using Kaplan–Meier curves and logistic regression. Results A total of 96 patients were included in this study. The median age was 22 years, and the proportion of male patients was 48.4%. Lesions were most frequently located in the frontal lobe (52.6%). MI was positive in 39.6% of all patients. The median OS was 14.4 months. Univariate logistic regression analysis revealed that OS was significantly worse in the MI-positive group compared with the MI-negative group. Multivariate logistic regression analysis revealed that MI was an independent prognostic factor in DHGs. Conclusions In this study, MI-positive cases had a worse prognosis compared with MI-negative cases. Previous presentations No portion of this study has been presented or published previously.

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Multiple drugs

2024

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Imaging features of diffuse hemispheric glioma, H3 G34-mutant: Report of 4 cases

Cited by 3 publications

References 9 publications

H3G34-Mutant Gliomas—A Review of Molecular Pathogenesis and Therapeutic Options

H3G34-Mutant Gliomas—A Review of Molecular Pathogenesis and Therapeutic Options

Midline invasion predicts poor prognosis in diffuse hemispheric glioma, H3 G34-mutant: an individual participant data review

Multiple drugs

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