Image-Guided Ablation in Breast Cancer Treatment

Roubidoux, Marilyn A.; Yang, Wei; Stafford, R. Jason

doi:10.1053/j.tvir.2013.12.008

Cited by 35 publications

(23 citation statements)

References 33 publications

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“…Clinically approved applications include lowintensity, nonfocused exposures for healing in physical therapy [15], and higher-intensity FUS for noninvasively ablating a variety of benign and malignant tumors [16]. The latter includes the treatment of uterine fibroids [17], breast cancer [18], and bone metastasis [19]. FUS is FDA approved for uterine fibroids, bone metastases, prostate cancer, and benign prostatic hyperplasia.…”

Section: A Brief History Of Fusmentioning

confidence: 99%

Focused Ultrasound: An Emerging Therapeutic Modality for Neurologic Disease

Fishman

Frenkel

2017

Neurotherapeutics

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Therapeutic ultrasound is only beginning to be applied to neurologic conditions, but the potential of this modality for a wide spectrum of brain applications is high. Engineering advances now allow sound waves to be targeted through the skull to a brain region selected with real time magnetic resonance imaging and thermography, using a commercial array of focused emitters. High intensities of sonic energy can create a coagulation lesion similar to that of older radiofrequency stereotactic methods, but without opening the skull. This has led to the recent Food and Drug Administration approval of focused ultrasound (FUS) thalamotomy for unilateral treatment of essential tremor. Clinical studies of stereotactic FUS for aspects of Parkinson's disease, chronic pain, and refractory psychiatric indications are underway, with promising results. Moderate-intensity FUS has the potential to safely open the blood-brain barrier for localized delivery of therapeutics, while low levels of sonic energy can be used as a form of neuromodulation.

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Section: A Brief History Of Fusmentioning

confidence: 99%

Focused Ultrasound: An Emerging Therapeutic Modality for Neurologic Disease

Fishman

Frenkel

2017

Neurotherapeutics

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“…The former includes the treatment of uterine fibroids,18 breast cancer,19 and bone metastasis20 and the latter being for palliative purposes.…”

Section: Fus: Principles Of Operationmentioning

confidence: 99%

Treatment of Movement Disorders With Focused Ultrasound

Fishman

Frenkel

2017

J Cent Nerv Syst Dis

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Although the use of ultrasound as a potential therapeutic modality in the brain has been under study for several decades, relatively few neuroscientists or neurologists are familiar with this technology. Stereotactic brain lesioning had been widely used as a treatment for medically refractory patients with essential tremor (ET), Parkinson disease (PD), and dystonia but has been largely replaced by deep brain stimulation (DBS) surgery, with advantages both in safety and efficacy. However, DBS is associated with complications including intracerebral hemorrhage, infection, and hardware malfunction. The occurrence of these complications has spurred interest in less invasive stereotactic brain lesioning methods including magnetic resonance imaging–guided high intensity–focused ultrasound (FUS) surgery. Engineering advances now allow sound waves to be targeted noninvasively through the skull to a brain target. High intensities of sonic energy can create a coagulation lesion similar to that of older radiofrequency stereotactic methods, but without opening the skull, recent Food and Drug Administration approval of unilateral thalamotomy for treatment of ET. Clinical studies of stereotactic FUS for aspects of PD are underway. Moderate intensity, pulsed FUS has also demonstrated the potential to safely open the blood-brain barrier for localized delivery of therapeutics including proteins, genes, and cell-based therapy for PD and related disorders. The goal of this review is to provide basic and clinical neuroscientists with a level of understanding to interact with medical physicists, biomedical engineers, and radiologists to accelerate the application of this powerful technology to brain disease

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“…An emerging indication of cryoablation is breast cancer. In the last decade, percutaneous US-guided ablation has been used successfully in the treatment of breast cancer [ 13 – 15 ]. Ideal patients for ablation are elderly women with small (<2 cm) tumours and no axillary involvement or distant metastasis.…”

Section: Cryoablation In the Breastmentioning

confidence: 99%

Use of cryoablation beyond the prostate

Yılmaz

Özdoğan²,

Cevener

et al. 2016

Insights Imaging

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Cryoablation has been used for many years as a surgical ablation technique in the prostate and kidney. However, since the introduction of high-intensity focused ultrasound (HIFU) and robotic surgery for prostate tumours, its popularity in the urologic community has declined. In the early 2000s, innovations in cryoablation technology allowed the use of thinner probes, which were suitable for percutaneous application. As a result, radiologists began using cryoablation, first in the liver, and then in other organs or tissues such as the kidney, lung, breast, pancreas, bone, and soft tissue. In most of these locations, cryoablation has great potential given its inherent advantages, including the use of local anaesthesia, little or no pain during and after the procedure, real-time monitoring of the ablation area on US, CT or MRI, the potential for ablation of large tumours with multiple probes, and the ability to change the shape of the ablation in non-spherical tumours. Yet despite these advantages, the use of percutaneous cryoablation among radiologists appears to be far lower than that of heat-based ablation techniques. The aim of this article is to outline specific aspects of cryoablation and to illustrate its potential clinical applications with case presentations.Key Points• Recent advances have made cryoablation suitable for percutaneous use by radiologists with image guidance.• Cryoablation has distinct advantages over heat-based ablation techniques.• Cryoablation is becoming increasingly popular for lung, breast, kidney, bone, and soft tissue tumours.

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Image-Guided Ablation in Breast Cancer Treatment

Cited by 35 publications

References 33 publications

Focused Ultrasound: An Emerging Therapeutic Modality for Neurologic Disease

Focused Ultrasound: An Emerging Therapeutic Modality for Neurologic Disease

Treatment of Movement Disorders With Focused Ultrasound

Use of cryoablation beyond the prostate

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