Iloprost Added to the Cardioplegic Solutions Improves Myocardial Performance

Katırcıoğlu, Salih Fehmi; Saritaş, Zülfikar Kadir; Ulus, A. Tulga; Yamak, Birol; Yücel, Doğan; Ayaz, Selime

doi:10.1016/s0090-6980(98)00006-9

Cited by 6 publications

(7 citation statements)

References 43 publications

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“…In literature several iloprost studies have shown that antiinflammatory parameters decreased in the I/R injury condition. [26][27][28] In our study, we did not evaluate the measured anti-inflammatory parameters but histopatological results and contraction relaxation responses of the intestinal tissues were observed in the iloprost group. Although the results were better than the I/R group, it was not statistically significant.…”

Section: Discussionmentioning

confidence: 99%

The Role Of Pentoxifylline And Iloprost In Prevention Of Ischemia-reperfusion injury in Experimental Model Of Intestine Ischemia-reperfusion In Rats.

Abakay¹,

Soylu

Göksel³

et al. 2018

Ulus Travma Acil Cerrahi Derg

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BACKGROUND: Intestinal ischemia-reperfusion (I/R) injury can lead to multiple organ failure and death. The aim of this study was to investigate the effects of pentoxifylline and iloprost administered before reperfusion in intestinal ischemia. METHODS:In total, 25 male Wistar Albino rats weighing 250-300 g were divided into five groups each comprising five subjects: control group (n=5), sham group (n=5, no I/R), I/R group (n=5, 45 min ischemia, and 120 min reperfusion), I/R + pentoxifylline group (n=5, 45 min ischemia following intraperitoneal 50 mg/kg pentoxifylline and 120 min reperfusion), and I/R + iloprast group (n=5, 45 min ischemia followed by intraperitoneal 2 mcg /kg iloprost and 120 min reperfusion). At the end of the experiment, ileum specimens were stained using hematoxylin-eosin and histopathologically evaluated using the Chiu score. Isometric contraction-relaxation responses were recorded using organ baths for contraction-relaxation responses. RESULTS:Pentoxifylline provided a significant improvement in response to histopathological and contraction-relaxation responses. Although iloprost provided recovery in reperfusion injury, it was not statistically significant. CONCLUSION:Our findings demonstrate that pentoxifylline may be promising in preventing small bowel ischemia-reperfusion injury. We concluded that further clinical and experimental studies for iloprost are needed.

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Section: Discussionmentioning

confidence: 99%

The Role Of Pentoxifylline And Iloprost In Prevention Of Ischemia-reperfusion injury in Experimental Model Of Intestine Ischemia-reperfusion In Rats.

Abakay¹,

Soylu

Göksel³

et al. 2018

Ulus Travma Acil Cerrahi Derg

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“…This protection is broken down after the oxygen free radical release [45]. With reperfusion, reactive oxygen molecules impair the structure of membrane lipids and other cellular components.…”

Section: Discussionmentioning

confidence: 99%

Effect of Mg<sub>2</sub>SO<sub>4</sub> Usage on Spinal Cord Ischemia-Reperfusion Injury: Electron Microscopic and Functional Evaluation

et al. 2004

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Objectives: To evaluate the effects of intravenous magnesium sulfate (Mg₂SO₄) administration on ischemia-reperfusion injury of the spinal cord. Material and Methods: Sixteen rabbits were randomly assigned to the control (group I, 8 rabbits) and the study group (group II, 8 rabbits). The abdominal aorta was clamped for a period of 30 min followed by a reperfusion period of 60 min. The animals in group II received 0.25 ml/kg/h Mg₂SO₄ intravenous infusion (15% Mg₂SO₄) throughout this procedure. The animals were then observed for 24 h after which their neurological states were evaluated and tissue samples obtained from the spinal cord were examined with electron microscopy. Results: Aortic pressure distal to the cross-clamp during the occlusion period was 9 ± 3 mm Hg in group I and 19 ± 6 mm Hg in group II. All animals in group I were paraplegic at the end of the study. In group II the neurological outcome of 1 animal was poor while the other 7 animals were neurologically in a good condition. Electron microscopic examinations of the spinal cord tissues of group I revealed severe injury but the ultrastructure was well preserved in group II. Conclusions: Intravenous Mg₂SO₄ administration may have protective effects on the ischemia-reperfusion injury of the spinal cord. We propose that Mg₂SO₄ may be an additional protective pharmacological agent in thoracal and thoracoabdominal aortic surgery.

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“…Adenosine triphosphate measurement; the tissue samples were placed in ice cold perchloric acid (0.3 M) and was stored in liquid nitrogen (-196°C). Their measurements were calculated with Sigmadon UV-1208 spectrophotometri device (Tokyo-Japan) [15]. The Hydragel ISO-CK kit is designed for the separation and quantification of Creatine Phosphokinase (CK) isoenzymes in human serum by electrophoresis on agarose gel (Sebia, ISO-CK kit) [15].…”

Section: Metabolic Measurementsmentioning

confidence: 99%

“…Their measurements were calculated with Sigmadon UV-1208 spectrophotometri device (Tokyo-Japan) [15]. The Hydragel ISO-CK kit is designed for the separation and quantification of Creatine Phosphokinase (CK) isoenzymes in human serum by electrophoresis on agarose gel (Sebia, ISO-CK kit) [15]. Tumor necrosis factor levels were measured by enzyme immunoassay (ELISA; T Cell Diagnostic, Inc., USA) [15].…”

Section: Metabolic Measurementsmentioning

confidence: 99%

“…The Hydragel ISO-CK kit is designed for the separation and quantification of Creatine Phosphokinase (CK) isoenzymes in human serum by electrophoresis on agarose gel (Sebia, ISO-CK kit) [15]. Tumor necrosis factor levels were measured by enzyme immunoassay (ELISA; T Cell Diagnostic, Inc., USA) [15]. P-selectin and ICAM-l1evels were measured by enzyme immunoassay (ELISA; Bender MedSystems, Vienna, Austria, Europe) [15].…”

Section: Metabolic Measurementsmentioning

confidence: 99%

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Comparison of Metabolic Responses to Deep Hypothermic Total Circulatory Arrest and Retrograde Cerebral Perfusion in an Experimental Model

Katırcıoğlu

Saritaş

Kügüker

et al. 2002

Cardiovascular Surgery

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An experimental study was designed to search the effectiveness of retrograde cerebral perfusion which is presently used as cerebral protection method for the surgery of arcus aorta. Twelve dogs were subjected to the study. Six of them were remained in total circulatory arrest at 20 °C for 60 min. Retrograde cerebral perfusion was done again at 20 °C for 1 h for the other six dogs. Tumor necrosis factor (TNF). P-selectin, Intracelluler Adhesion Molecule (ICAM), Creatine Phosphokinase (CPK-BB) and tissue Adenosine triphosphate (ATP) levels were measured, before the cardiopulmonary bypass at 37 °C and during perfusion period at 5, 60 min and 4 h. Tissue ATP level for retrograde cerebral perfusion group was 3.99±0.7 mcmol/g tissue and 2.8610.1 mcmol/g tissue for total circulatory arrest group at fourth hour (p<0.05). TNF level was significantly higher in total circulatory arrest group than retrograde cerebral perfusion group (p<0.05). The samples taken at fourth hour of reperfusion showed the TNF level was, 162.55±13.1 pcg/ml for total circulatory arrest group and this value was 12.5±3.4 pcg/ml for retrograde cerebral perfusion group. ICAM (Intracelluler Adhesion Molecule) level was higher in total circulatory arrest group (18.751±3.6 ng/ml) when compared to retrograde cerebral perfusion group (8.75±1.8 ng/ml) (p<0.05). All parameters showed that retrograde cerebral perfusion preserved the brain functions better comparing with total circulatory arrest. The time necessary for aortic surgery may be provided by the retrograde cerebral perfusion technique.

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Iloprost Added to the Cardioplegic Solutions Improves Myocardial Performance

Cited by 6 publications

References 43 publications

The Role Of Pentoxifylline And Iloprost In Prevention Of Ischemia-reperfusion injury in Experimental Model Of Intestine Ischemia-reperfusion In Rats.

The Role Of Pentoxifylline And Iloprost In Prevention Of Ischemia-reperfusion injury in Experimental Model Of Intestine Ischemia-reperfusion In Rats.

Effect of Mg<sub>2</sub>SO<sub>4</sub> Usage on Spinal Cord Ischemia-Reperfusion Injury: Electron Microscopic and Functional Evaluation

Comparison of Metabolic Responses to Deep Hypothermic Total Circulatory Arrest and Retrograde Cerebral Perfusion in an Experimental Model

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