ILIB (intravascular laser irradiation of blood) as an adjuvant therapy in the treatment of patients with chronic systemic diseases—an integrative literature review

Tomé, Ruan Felipe Ferreira; Silva, Diego Filipe Bezerra; Santos, Carlus Alberto Oliveira dos; Neves, Gabriella de Vasconcelos; Rolim, Ana Karina Almeida; Gomes, Daliana Queiroga de Castro

doi:10.1007/s10103-020-03100-4

Cited by 29 publications

(26 citation statements)

References 24 publications

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“…In a review study performed by Tomé et al 8 , treatment in diabetic patients with ILIB therapy was efficient in reducing serum glucose levels in patients with type 2 DM. The protocol adopted was the punctual application of red laser (630 nm) for 30 minutes for 14 consecutive sessions, and the patients had their glycemic levels measured by digital monitoring.…”

Section: Discussionmentioning

confidence: 99%

“…The choice of ILIB therapy in the present study was based on its prevalent use in diabetic patients, as shown in the review by Tomé et al 8 . It was also observed that ILIB is capable of promoting reduction in the levels of pro-inflammatory interleukin 1 and interleukin 6 and increase in the levels of anti-inflammatory interleukin 10.…”

Section: Discussionmentioning

confidence: 99%

“…LLLT in healthy tissues is able to produce reactive oxygen species (ROS). However, when applied under conditions of oxidative stress, there is reduction in ROS synthesis 8 .…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, ILIB therapy, in addition to the expected effects of laser therapy, modulates the signaling of reactive enzymes in the respiratory chain, through mitochondrial components, inducing positive effects on the expression of immunoglobulins, interferons and interleukins, being able to promote an increase in the supply of oxygen to the tissues, ceasing tissue hypoxia, normalizing metabolism, and improving the oxidation of energy transport molecules, glucose and pyruvate, due to the greater production of adenosine triphosphate. Recent studies have pointed out its use in several systemic conditions 8 , 9 .…”

Section: Introductionmentioning

confidence: 99%

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Effect of electrophysical resources on healing of neurotendinous injury in an experimental model of type I diabetes and kidney disease

Silva

Facco

et al. 2022

Acta Cir. Bras.

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To evaluate and describe the effect of electrophysical resources laser therapy (LLLT), intravascular laser blood irradiation (ILIB), and cryotherapy on the healing process of neurotendinous injury, as well as possible systemic changes, in the experimental model of type 1 diabetes associated with kidney injury. Methods: The animals were randomized into four groups: G1) healthy control with untreated injury; G2) healthy control with injury and treatment; G3) disease control with untreated lesion; G4) disease with injury and treatment. Furthermore, the treated groups were divided into three, according to the type of treatment. All animals were induced to neurotendinous injury and treated according to the therapeutic protocols. Healing and inflammation were analyzed by semiquantitative histopathological study. Results: It was observed in sick animals treated with cryotherapy and ILIB reduction of inflammatory exudate, presence of fibroblasts and organization of collagen, when compared to the effects of LLLT. Moreover, there was reduction in glycemic levels in the group treated with ILIB. Conclusions: Cryotherapy promoted reduction in inflammatory exudate and organization of collagen fibers, in addition to the absence of signs of tissue necrosis, in the groups treated with and without the disease. ILIB therapy showed the same findings associated with significant reduction in glycemic levels in the group of diseased animals. The application of LLLT showed increased inflammatory exudate, low organization of collagen fibers and low sign of tissue degeneration and necrosis.This study in a model of associated diseases (diabetes and kidney disease) whose effects of electrophysical resources studied after neurotendinous injury allows us to verify histopathological variables suggestive of patients with the same comorbidities.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…LLLT in healthy tissues is able to produce reactive oxygen species (ROS). However, when applied under conditions of oxidative stress, there is reduction in ROS synthesis 8 .…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of electrophysical resources on healing of neurotendinous injury in an experimental model of type I diabetes and kidney disease

Silva

Facco

et al. 2022

Acta Cir. Bras.

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“…LLLT can be used with the ILIB technique (Intravascular Laser Irradiation of Blood), which increases immunity, inducing positive effects on the expression of immunoglobulins (IgA, IgM and IgG) and modulation of inflammation. Therefore, this technique can be used to treat various pathogens such as infectious diseases, bronchitis, and pneumonia [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

Photobiomodulation Therapy as a Possible New Approach in COVID-19: A Systematic Review

Matos

Buchaim

Pomini

et al. 2021

Life

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COVID-19 is a viral disease characterized as a pandemic by the World Health Organization in March 2020. Since then, researchers from all over the world have been looking for ways to fight this disease. Many cases of complications arise from insufficient immune responses due to low immunity, with intense release of pro-inflammatory cytokines that can damage the structure of organs such as the lung. Thus, the hypothesis arises that photobiomodulation therapy (PBMT) with the use of a low-level laser (LLLT) may be an ally approach to patients with COVID-19 since it is effective for increasing immunity, helping tissue repair, and reducing pro-inflammatory cytokines. This systematic review was performed with the use of PubMed/MEDLINE, Web of Science, Scopus and Google Scholar databases with the following keywords: “low-level laser therapy OR photobiomodulation therapy AND COVID-19”. The inclusion criteria were complete articles published from January 2020 to January 2021 in English. The exclusion criteria were other languages, editorials, reviews, brief communications, letters to the editor, comments, conference abstracts, and articles that did not provide the full text. The bibliographic search found 18 articles in the Pubmed/MEDLINE database, 118 articles on the Web of Science, 23 articles on Scopus, and 853 articles on Google Scholar. Ten articles were included for qualitative synthesis, of which four commentary articles discussed the pathogenesis and the effect of PBMT in COVID-19. Two in vitro and lab experiments showed the effect of PBMT on prevention of thrombosis and positive results in wound healing during viral infection, using the intravascular irradiation (ILIB) associated with Phthalomethyl D. Two case reports showed PBMT improved the respiratory indexes, radiological findings, and inflammatory markers in severe COVID-19 patients. One case series reported the clinical improvement after PBMT on 14 acute COVID-19 patients, rehabilitation on 24 patients, and as a preventive treatment on 70 people. One clinical trial of 30 patients with severe COVID-19 who require invasive mechanical ventilation, showed PBMT-static magnetic field was not statistically different from placebo for the length of stay in the Intensive Care Unit, but improved diaphragm muscle function and ventilation and decreased the inflammatory markers. This review suggests that PBMT may have a positive role in treatment of COVID-19. Still, the necessity for more clinical trials remains in this field and there is not sufficient research evidence regarding the effects of PBMT and COVID-19 disease, and there is a large gap.

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Photobiomodulation in diabetic rats: Effects on morphological, pancreatic parameters, and glucose homeostasis

Pandolfo,

Bonifacio,

Benfato

et al. 2023

Journal of Biophotonics

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Photobiomodulation (PBM) has therapeutic effects on wound healing, diabetic microangiopathy and retinopathy. However, little is known about the use of PBM for the treatment of diabetes mellitus (DM). In this context, we aimed to evaluate the effects of PBM on pancreas morphology and insulin and glucose tolerance in an experimental model of DM. Thus, DM was induced by STZ (60 mg/Kg). Subsequently, the rats were treated with PBM (808 nm and 30 J/cm2). After euthanasia, morphometric parameters and immunoreactivity for insulin and 8‐OHdG were evaluated in the pancreas. The results showed that treated animals had higher values of body mass and higher values in the number of beta cells in the pancreas. In conclusion, PBM resulted in decreased weight loss in STZ‐induced diabetic rats and presented a stimulatory effect on the pancreas of the treated animals, highlighting the promising effects of this therapy in the clinical condition of DM.

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ILIB (intravascular laser irradiation of blood) as an adjuvant therapy in the treatment of patients with chronic systemic diseases—an integrative literature review

Cited by 29 publications

References 24 publications

Effect of electrophysical resources on healing of neurotendinous injury in an experimental model of type I diabetes and kidney disease

Effect of electrophysical resources on healing of neurotendinous injury in an experimental model of type I diabetes and kidney disease

Photobiomodulation Therapy as a Possible New Approach in COVID-19: A Systematic Review

Photobiomodulation in diabetic rats: Effects on morphological, pancreatic parameters, and glucose homeostasis

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