ILC3s control airway inflammation by limiting T cell responses to allergens and microbes

Teng, Fei; Tachó-Piñot, Roser; Sung, Biin; Farber, Donna L.; Worgall, Stefan; Hammad, Hamida; Lambrecht, Bart; Hepworth, Matthew R.; Sonnenberg, Gregory F.

doi:10.1016/j.celrep.2021.110051

Cited by 19 publications

(13 citation statements)

References 63 publications

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“…DCs in the steady state express low MHC-II levels and induce Tregs, Th17, Th1, and Th2 to maintain a normal immune response. 40,41 OVA, a common food antigen, is recognized by DCs, which are MHC-II-dependent APCs. 42 Activated MHC-II enhances the Th2 cell immune response and releases the cytokines IL-4 and IL-13, which are associated with intestinal inflammation.…”

Section: Papermentioning

confidence: 99%

Synergistic effects of l-theanine and epigallocatechin gallate in alleviating ovalbumin allergy by regulating intestinal immunity through inhibition of mast cell degranulation

Gong

et al. 2023

Food Funct.

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Section: Papermentioning

confidence: 99%

Synergistic effects of l-theanine and epigallocatechin gallate in alleviating ovalbumin allergy by regulating intestinal immunity through inhibition of mast cell degranulation

Gong

et al. 2023

Food Funct.

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“…Differences in HDM constituents between different lots could be a potential source of different results, as we experienced more than 10-fold differences in protein content per weight. Moreover, drastic differences in microbiota contained in HDM sources were recently noticed between different vendors ( 160 ). Thus, standardization of HDM preparations or use of single or combination of pure allergens is highly desirable.…”

Section: Discussionmentioning

confidence: 99%

Immunoglobulin E-Dependent Activation of Immune Cells in Rhinovirus-Induced Asthma Exacerbation

et al. 2022

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Acute exacerbation is the major cause of asthma morbidity, mortality, and health-care costs. Respiratory viral infections, particularly rhinovirus (RV) infections, are associated with the majority of asthma exacerbations. The risk for bronchoconstriction with RV is associated with allergic sensitization and type 2 airway inflammation. The efficacy of the humanized anti-IgE monoclonal antibody omalizumab in treating asthma and reducing the frequency and severity of RV-induced asthma exacerbation is well-known. Despite these clinical data, mechanistic details of omalizumab's effects on RV-induced asthma exacerbation have not been well-defined for years due to the lack of appropriate animal models. In this Perspective, we discuss potential IgE-dependent roles of mast cells and dendritic cells in asthma exacerbations.

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“…Belonging to the heterogeneous family of innate lymphocytes enriched in the mucosal barrier [ 161 ], ILCs are regarded as an important component of innate immunity to protect against pathogens. It was noticed that ILC3, another subset of ILCs, limits the expansion of allergen-specific CD 4+ T cells through a mechanism related to its presentation of microbial antigens in the gastrointestinal tract [ 162 , 163 , 164 ]. Nevertheless, still few studies focus on the hypothesis which remains to be explored and confirmed by conducting more studies.…”

Section: Compositions Of Epithelial Barriermentioning

confidence: 99%

Epithelial Barrier in the Nasal Mucosa, Related Risk Factors and Diseases

Zhang

et al. 2023

Int Arch Allergy Immunol

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As the first line of defense against risk factors, the nasal epithelial barrier maintains homeostasis in nasal mucosa. The composition of the epithelial barrier contains physical, chemical, immune, and microbiological barriers. Together, these barriers form the nasal defense against irritations. Risk factors from both internal and external environments can disrupt them. External risk factors contain allergens containing proteases, bacteria, virus, particulate matter, diesel exhaust particles, and cigarette smoke. In the meantime, inflammatory cytokines also increase the load on the barrier. Taking into account the role of the epithelial barrier in the nasal mucosa, some studies focus on the treatment of allergic rhinitis (AR) and chronic rhinosinusitis (CRS) by restoring the epithelial barrier, and some progress has been made. Among the therapeutic approaches, histone deacetylase (HDAC) inhibitor and steroid corticosteroids are considered two of the more studied categories, and their roles in repairing barriers have been demonstrated in AR and CRS. The underlying mechanism of HDAC inhibitor may be related to the transcription factor p63. And the protection of corticosteroids may be associated with the allergic disease susceptibility gene, protocadherin-1. Notably, manipulation of the microbiological barrier also has a positive effect on AR and CRS. <i>Lactococcus</i> and probiotics are two categories that are worth being explored continuously. We here review and discuss the compositions and risk factors of the nasal epithelial barrier. Furthermore, some novel and promising approaches to restore the defective barrier in nasal allergic diseases were mentioned.

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ILC3s control airway inflammation by limiting T cell responses to allergens and microbes

Cited by 19 publications

References 63 publications

Synergistic effects of l-theanine and epigallocatechin gallate in alleviating ovalbumin allergy by regulating intestinal immunity through inhibition of mast cell degranulation

Synergistic effects of l-theanine and epigallocatechin gallate in alleviating ovalbumin allergy by regulating intestinal immunity through inhibition of mast cell degranulation

Immunoglobulin E-Dependent Activation of Immune Cells in Rhinovirus-Induced Asthma Exacerbation

Epithelial Barrier in the Nasal Mucosa, Related Risk Factors and Diseases

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